Search Results - "A Helm, Birgit"

Solid-Phase Synthesis of an A−B Loop Mimetic of the Cε3 Domain of Human IgE:  Macrocyclization by Sonogashira Coupling by Spivey, Alan C, McKendrick, John, Srikaran, Ratnasothy, Helm, Birgit A

“…The solid-phase synthesis of a cyclic peptide containing the 21-residue epitope found in the A−B loop of the Cε3 domain of human immunoglobulin E has been…”
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A novel insight to the functional role of Stathmin 1 in IgE-mediated activation of RBL-2H3 cells by Sadroddiny, Esmaeil, Moir, Arthur J G, A Helm, Birgit

“…IgE-mediated cell signaling, induced by cross-linking of high affinity receptor for IgE (FcεRI) in the presence of antigen (Ag), is a well known mechanism…”
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Identification of amino acid residues involved in the interaction of canine IgE with canine and human FcεRIα by Ye, Hongtu, Housden, Jonathan E M, Hunter, Michael, Sabban, Sari, Helm, Birgit A

“…The interaction of immunoglobulin E (IgE) antibodies with the high-affinity receptor (FcεRI) is important in anti-parasitic immunity and plays a central role…”
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The role of C epsilon 2, C epsilon 3, and C epsilon 4 domains in human and canine IgE and their contribution to Fc epsilon RI alpha interaction by Ye, Hongtu, Housden, Jonathan EM, Hunter, Michael J, Sabban, Sari, Helm, Birgit A

“…The C epsilon 2 and C epsilon 4 domains are considered as scaffolds, allowing C epsilon 3 domains to assume an appropriate orientation to interact with Fc…”
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Synthesis and Incorporation into Cyclic Peptides of Tolan Amino Acids and Their Hydrogenated Congeners: Construction of an Array of A–B-loop Mimetics of the Cε3 Domain of Human IgE by Offermann, Daniel A, McKendrick, John E, Sejberg, Jimmy J. P, Mo, Bingli, Holdom, Mary D, Helm, Birgit A, Leatherbarrow, Robin J, Beavil, Andrew J, Sutton, Brian J, Spivey, Alan C

“…The disruption of the human immunolobulin E–high affinity receptor I (IgE–FcεRI) protein–protein interaction (PPI) is a validated strategy for the development…”
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Fc receptor-γ subunits with both polar or non-polar amino acids at position of T22 are capable of restoring surface expression of the high-affinity IgE receptor and degranulation in γ subunit-deficient rat basophilic leukemia cells by Rashid, Amir, Housden, Jonathan E.M., Helm, Birgit A., Draber, Petr

“…► High affinity IgE receptor (FcɛRI) is composed of 3 different subunits (αβγ2). ► A new model suggested that Asp194 in α subunit interacts with Thr22 in γ…”
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A proteomics approach to the study of the molecular consequence of IgE-mediated cell signalling in RBL-2H3.1 cells and 2D reference map preparation for the RBL-2H3.1 cell line by Sadroddiny, Esmaeil, Moir, Arthur J G, Helm, Birgit A

“…A highly reproducible 2D (two‐dimensional) map for the proteome and a pattern of protein phosphorylation of high secretory variant of RBL‐2H3 cells (RBL‐2H3.1)…”
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Proteomic identification and characterization of secreted N-glycosylated NPC2 following cross-linking of the high-affinity receptor for IgE on mast cells by Pathak, Ashutosh K., Helm, Birgit A.

“…Allergen‐mediated cross‐linking of the high‐affinity receptor for IgE on mast cells triggers the release of diverse preformed and de novo synthesized…”
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Assessing the role of Asp 194 in the transmembrane domains of the α-chain of the high-affinity receptor complex for immunoglobulin E in signal transduction by Rashid, Amir, Iodice, Marco W., Carroll, Kathleen M., Housden, Jonathan E.M., Hunter, Michael, Sabban, Sari, Artymiuk, Peter J., Helm, Birgit A.

“…The high-affinity receptor complex for IgE plays a pivotal role in allergic responses since cross-linking of the high-affinity IgE receptor (FcɛRI) on target…”
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Generation of canine-human Fc IgE chimeric antibodies for the determination of the canine IgE domain of interaction with Fc epsilon RI alpha by Hunter, Michael J, Vratimos, Athanassios P, Housden, Jonathan E M, Helm, Birgit A

“…Identification of the domain(s) of canine IgE that interact with Fc epsilon RI alpha may lead to novel therapeutic intervention strategies that inhibit the…”
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The Importance of Lys-352 of Human Immunoglobulin E in FcϵRII/CD23 Recognition by Sayers, Ian, Housden, Jonathan E.M., Spivey, Alan C., Helm, Birgit A.

“…The interaction of immunoglobulin E (IgE) with its low affinity receptor (Fc epsilon RII/CD23) plays a central role in the initiation and regulation of type I…”
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Amino Acid Residues That Influence FcεRI-Mediated Effector Functions of Human Immunoglobulin E by Sayers, Ian, Cain, Stuart A, Swan, Jillian R. M, Pickett, Mark A, Watt, Peter J, Holgate, Stephen T, Padlan, Eduardo A, Schuck, Peter, Helm, Birgit A

“…Immunoglobulin E (IgE) mediates its effector functions via the Fc region of the molecule. IgE binding to and subsequent aggregation of the high-affinity…”
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Identification of the High Affinity Receptor Binding Region in Human Immunoglobulin E (∗) by Helm, Birgit A., Sayers, Ian, Higginbottom, Adrian, Machado, Denise Cantarelli, Ling, Yan, Ahmad, Khalid, Padlan, Eduardo A., Wilson, A. Penelope M.

“…We have investigated the capacity of N- and C-terminally truncated and chimeric human (h) IgE-derived peptides to inhibit the binding of 125I-labeled hIgE, and…”
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Assessment of the Molecular Basis of the Proallergenic Effects of Cigarette Smoke by Smyth, Lucy J. C, Machado, Denise C, Upton, Anthony P, Good, Samantha, Aufderheide, Michaela, Helm, Birgit A

“…Epidemiological studies indicate a link between smoking and increased risk of immunoglobulin E-mediated allergies and asthma. The molecular basis underlying…”
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Identification of amino acid residues involved in the interaction of canine IgE with canine and human FcɛRIα by Ye, Hongtu, Housden, Jonathan E.M., Hunter, Michael, Sabban, Sari, Helm, Birgit A.

“…•The extracellular domains of hu/ca FcɛRIα were expressed in Pichia pastoris.•The binding of IgE variants to hu/ca FcɛRIα was assessed by β-hexosaminidase…”
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The role of Cɛ2, Cɛ3, and Cɛ4 domains in human and canine IgE and their contribution to FcɛRIα interaction by Ye, Hongtu, Housden, Jonathan E.M., Hunter, Michael J., Sabban, Sari, Helm, Birgit A.

“…•We expressed the extracellular domains of hu/ca FcɛRIα in Pichia pastoris.•The binding of chimeric IgE to hu/ca FcɛRIα was assessed by β-hexosaminidase…”
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Immunological effects of grain dust by Gould, J R, Crook, B, Helm, B A, Blainey, D A, Power, M

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Characterization of an early signaling defect following FcɛRI activation in the canine mastocytoma cell line, C2 by Hunter, Michael J., Iodice, Marco W., Pathak, Ashutosh K., Street, Mark A., Helm, Birgit A.

“…A comparison of IgE recognition by cognate receptors expressed on the C2 canine mastocytoma cell line with analogous events in a rat basophilic leukemia cell…”
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The role of Cε2, Cε3, and Cε4 domains in human and canine IgE and their contribution to FcεRIα interaction by Ye, Hongtu, Housden, Jonathan E M, Hunter, Michael J, Sabban, Sari, Helm, Birgit A

“…The Cε2 and Cε4 domains are considered as scaffolds, allowing Cε3 domains to assume an appropriate orientation to interact with FcεRI (Wurzburg and Jardetzky,…”
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Generation of canine-human Fc IgE chimeric antibodies for the determination of the canine IgE domain of interaction with Fc[var epsilon]RI alpha by Hunter, Michael J, Vratimos, Athanassios P, Housden, Jonathan EM, Helm, Birgit A

“…Identification of the domain(s) of canine IgE that interact with Fc[var epsilon]RI alpha may lead to novel therapeutic intervention strategies that inhibit the…”
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