Search Results - "A Hassan, Alaa"

Chemistry and Biological Activities of 1,2,4-Triazolethiones-Antiviral and Anti-Infective Drugs by Aly, Ashraf A, A Hassan, Alaa, Makhlouf, Maysa M, Bräse, Stefan

“…Mercapto-substituted 1,2,4-triazoles are very interesting compounds as they play an important role in chemopreventive and chemotherapeutic effects on cancer…”
Get full text

Repurposing of drug candidates against Epstein–Barr virus: Virtual screening, docking computations, molecular dynamics, and quantum mechanical study by Ibrahim, Mahmoud A. A, Hassan, Alaa M. A, Mohamed, Eslam A. R, Mekhemer, Gamal A. H, Sidhom, Peter A, El-Tayeb, Mohamed A, Khan, Shahzeb, Shoeib, Tamer, Soliman, Mahmoud E. S, Abdelrahman, Alaa H. M

“…Epstein–Barr virus (EBV) was the first tumor virus identified in humans, and it is mostly linked to lymphomas and cancers of epithelial cells. Nevertheless,…”
Get full text

Synthesis and Antiproliferative Potential of Thiazole and 4-Thiazolidinone Containing Motifs as Dual Inhibitors of EGFR and BRAFV600E by Hassan, Alaa A., Mohamed, Nasr K., Aly, Ashraf A., Ramadan, Mohamed, Gomaa, Hesham A. M., Abdel-Aziz, Ahmed T., Youssif, Bahaa G. M., Bräse, Stefan, Fuhr, Olaf

“…Thiazole and thiazolidinone recur in a wide range of biologically active compounds that reach different targets within the context of tumors and represent a…”
Get full text

Chemistry of Substituted Thiazinanes and Their Derivatives by Hassan, Alaa A, Bräse, Stefan, Aly, Ashraf A, Tawfeek, Hendawy N

“…Thiazinanes and its isomeric forms represent one of the most important heterocyclic compounds, and their derivatives represented a highly potent drug in…”
Get full text

Design, Synthesis, and Molecular Docking of Paracyclophanyl-Thiazole Hybrids as Novel CDK1 Inhibitors and Apoptosis Inducing Anti-Melanoma Agents by Aly, Ashraf A, Bräse, Stefan, Hassan, Alaa A, Mohamed, Nasr K, El-Haleem, Lamiaa E Abd, Nieger, Martin, Morsy, Nesrin M, Alshammari, Mohammed B, Ibrahim, Mahmoud A A, Abdelhafez, Elshimaa M N

“…Three new series of paracyclophanyl-dihydronaphtho[2,3- ]thiazoles and paracyclophanyl-thiazolium bromides were designed, synthesized, and characterized by…”
Get full text

New Paracyclophanylthiazoles with Anti-Leukemia Activity: Design, Synthesis, Molecular Docking, and Mechanistic Studies by Aly, Ashraf A, Bräse, Stefan, Hassan, Alaa A, Mohamed, Nasr K, Abd El-Haleem, Lamiaa E, Nieger, Martin, Morsy, Nesrin M, Abdelhafez, Elshimaa M N

“…A new series of methyl 2-(2-(4'-[2.2]paracyclophanyl)-hydrazinylidene)-3-substituted-4-oxothiazolidin-5-ylidene)acetates - were synthesized from the reaction…”
Get full text

Autoxidation of 4-Hydrazinylquinolin-2(1 H )-one; Synthesis of Pyridazino[4,3- c :5,6- c ']diquinoline-6,7(5 H ,8 H )-diones by Mostafa, Sara M, Aly, Ashraf A, Hassan, Alaa A, Osman, Esraa M, Bräse, Stefan, Nieger, Martin, Ibrahim, Mahmoud A A, Mohamed, Asmaa H

“…An efficient synthesis of a series of pyridazino[4,3- :5,6- ']diquinolines was achieved via the autoxidation of 4-hydrazinylquinolin-2(1 )-ones. IR, NMR ( H…”
Get full text

Functionalized 1,3-Thiazolidin-4-Ones from 2-Oxo-Acenaphthoquinylidene- and [2.2]Paracyclophanylidene-Thiosemicarbazones by Aly, Ashraf A, Mohamed, Nasr K, Hassan, Alaa A, El-Shaieb, Kamal M, Makhlouf, Maysa M, Bräse, Stefan, Nieger, Martin, Brown, Alan B

“…The reactions of dialkyl acetylenedicarboxylates with various 2-oxo-acenaphthoquinylidene- and 4-acetyl[2.2]paracyclophanylidene-thiosemicarbazones were…”
Get full text

Synthesis and Structure Determination of Substituted Thiazole Derivatives as EGFR/BRAFV600E Dual Inhibitors Endowed with Antiproliferative Activity by Al-Wahaibi, Lamya H., El-Sheref, Essmat M., Hassan, Alaa A., Bräse, S., Nieger, M., Youssif, Bahaa G. M., Ibrahim, Mahmoud A. A., Tawfeek, Hendawy N.

“…2,3,4-trisubstituted thiazoles 3a–i, having a methyl group in position four, were synthesized by the reaction of 1,4-disubstituted thiosemicarbazides with…”
Get full text

Synthesis of New Planar-Chiral Linked [2.2]Paracyclophanes- N -([2.2]-Paracyclophanylcarbamoyl)-4-([2.2]Paracyclophanylcarboxamide, [2.2]Paracyclophanyl-Substituted Triazolthiones and -Substituted Oxadiazoles by Aly, Ashraf A, Bräse, Stefan, Hassan, Alaa A, Mohamed, Nasr K, El-Haleem, Lamiaa E Abd, Nieger, Martin

“…The manuscript describes the synthesis of new racemic and chiral linked paracyclophane assigned as -5-(1,4(1,4)-dibenzenacyclohexaphane-1…”
Get full text

Synthesis of New Fused Heterocyclic 2-Quinolones and 3-Alkanonyl-4-Hydroxy-2-Quinolones by Aly, Ashraf A, Hassan, Alaa A, Mohamed, Nasr K, El-Haleem, Lamiaa E Abd, Bräse, Stefan, Polamo, Mika, Nieger, Martin, Brown, Alan B

“…Herein, we report the synthesis of 5,12-dihydropyrazino[2,3- :5,6- ']difuro[2,3- :4,5- ']-diquinoline-6,14( ,12 )diones,…”
Get full text

Synthesis of novel amidines via one-pot three component reactions: Selective topoisomerase I inhibitors with antiproliferative properties by El-Sheref, Essmat M., Tawfeek, Hendawy N., Hassan, Alaa A., Bräse, S., Elbastawesy, Mohammed A. I., Gomaa, Hesham A. M., Mostafa, Yaser A., Youssif, Bahaa G. M.

“…Novel series of amidines were synthesized via the interaction between alicyclic amines, cyclic ketones, and a highly electrophilic 4-azidoquinolin-2(1 H )-ones…”
Get full text

Crystal structure of ( E )-1-(3-benzyl-5-phenyl-1,3-thia-zol-2-yl-idene)-2-[( E )-1,2,3,4-tetra-hydro-naphthalen-1-yl-idene]hydrazin-1-ium bromide by Mohamed, Shaaban K, Elgarhy, Sahar M I, Hassan, Alaa A, Demirtaş, Güneş, Mague, Joel T, Ramli, Youssef

“…In the title mol-ecular salt, C H N S ·Br , the dihedral angles between the thia-zole ring and its attached phenyl and benzoyl rings are 54.81 (7) and 85.51…”
Get full text

Synthesis of (E)-2,5-disubstituted 1,3,4-thiadiazolyl-2,3-diphenylpropenones from alkenylidene-hydrazinecarbothioamides by Hassan, Alaa A., Abdel-Latif, Fathy F., Nour El-Din, Ahmed M., Mostafa, Sara M., Nieger, Martin, Bräse, Stefan

“…Conjugated alkenylidene-hydrazinecarbothioamides react in high yield with 2,3-diphenylcyclopropenone to give a series of (E)-2,5-disubstituted…”
Get full text

Synthesis of novel pyrazole derivatives and evaluation of their antidepressant and anticonvulsant activities by Abdel-Aziz, Mohamed, Abuo-Rahma, Gamal El-Din A., Hassan, Alaa A.

“…Substituted carboxylic acid hydrazides 1a– d reacted with ethenetetracarbonitril 2 in dimethyl formamide with the formation of diacylhydrazines 4a– d and…”
Get full text

Methyl (2Z)-2-{(2Z)-3-[(cyclo-pentyl-idene)amino]-4-oxo-2-phenyl-imino-1,3-thia-zol-idin-5-yl-idene}acetate by Mague, Joel T, Akkurt, Mehmet, Mohamed, Shaaban K, Hassan, Alaa A, Albayati, Mustafa R

“…In the title compound, C17H17N3O3S, the thia-zole ring is nearly planar [maximum deviation = 0.015 (1) Å for the ring N atom] and the cyclo-pentane ring has a…”
Get full text

(Z)-1-[(2E)-3,4-Diphenyl-2,3-di-hydro-1,3-thia-zol-2-yl-idene]-2-[1-(4-hy-droxy-phen-yl)ethyl-idene]hydrazinium bromide including an unknown solvate by Mague, Joel T, Mohamed, Shaaban K, Akkurt, Mehmet, Hassan, Alaa A, Albayati, Mustafa R

“…In the title compound, C23H20N3OS(+)·Br(-), the di-hydro-thia-zole ring (r.m.s. deviation = 0.015 Å) is twisted with respect to each of the C- and N-bound…”
Get full text

Crystal structure of 3-benzyl-1-[(1,2,3,4-tetrahydronaphthalen-1-ylidene)amino]thiourea by Mohamed, Shaaban K., Mague, Joel T., Akkurt, Mehmet, Hassan, Alaa A, Abdel-Aziz, Ahmed T., Albayati, Mustafa R.

“…In the title compound, C 18 H 19 N 3 S, the dihedral angle between the planes of the benzene rings is 58.63 (8)°. The six-membered ring bonded to the…”
Get full text

(1Z,2E)-1-(3,4-Diphenyl-2,3-di-hydro-1,3-thia-zol-2-yl-idene)-2-(1-p-tolyl-ethyl-idene)hydrazine by Mohamed, Shaaban K, Mague, Joel T, Akkurt, Mehmet, Hassan, Alaa A, Albayati, Mustafa R

“…In the title compound, C24H21N3S, the thia-zole ring makes dihedral angles of 52.03 (6), 62.63 (6) and 12.35 (6)°, respectively, with the two phenyl rings and…”
Get full text

Crystal structure of 3-(prop-2-en-1-yl)-1-{[(1 E )-1,2,3,4-tetrahydronaphthalen-1-ylidene]amino}thiourea by Mague, Joel T., Mohamed, Shaaban K., Akkurt, Mehmet, Hassan, Alaa A, Abdel-Aziz, Ahmed T., Albayati, Mustafa R.

“…In the title compound, C 14 H 17 N 3 S, the dihedral angle between the planes of the benzene ring and the thiosemicarbazone group (r.m.s. deviation = 0.031 Å)…”
Get full text