Search Results - "A Alshawsh, Mohammed"
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Technical aspects of preparing PEG-PLGA nanoparticles as carrier for chemotherapeutic agents by nanoprecipitation method
Published in International journal of pharmaceutics (25-11-2017)“…[Display omitted] Nanoprecipitation is a simple and increasingly trending method for nanoparticles preparation. The self-assembly feature of poly (ethylene…”
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Zerumbone Induces Apoptosis in Breast Cancer Cells by Targeting αvβ3 Integrin upon Co-Administration with TP5-iRGD Peptide
Published in Molecules (Basel, Switzerland) (13-07-2019)“…Cell-penetrating peptides (CPPs) are highly promising tools to deliver therapeutic molecules into tumours. αVβ3 integrins are cell-matrix adhesion receptors,…”
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Evaluation of Anti-Tumorigenic Effects of Diosmetin against Human Colon Cancer Xenografts in Athymic Nude Mice
Published in Molecules (Basel, Switzerland) (10-07-2019)“…Colon cancer is the third most common type of cancer in the world. Diosmetin (Dis), a natural -methylated flavone, has been reported to have anti-cancer…”
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Antiproliferative and Apoptotic Effects of Cardamonin against Hepatocellular Carcinoma HepG2 Cells
Published in Nutrients (12-06-2020)“…Liver cancer is the sixth most common cancer in terms of incidence and the fourth in terms of mortality. Hepatocellular carcinoma (HCC) represents almost 90%…”
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Effect of Catha edulis (khat) on pancreatic functions in streptozotocin-induced diabetes in male Sprague-Dawley rats
Published in Experimental Animals (2018)“…People consume Catha edulis (khat) for its euphoric effect, and type 1 diabetics have claimed that khat could reduce elevated levels of blood sugar. However,…”
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Physicochemical Characterization of Mitragyna speciosa Alkaloid Extract and Mitragynine using In Vitro High Throughput Assays
Published in Combinatorial chemistry & high throughput screening (01-11-2017)“…Mitragynine, a major active alkaloid of Mitragyna speciosa, acts as an agonist on µ-opioid receptors, producing effects similar to morphine and other opioids…”
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Biochemical and toxicological effects of methanolic extract of Asparagus africanus Lam in Sprague-Dawley rats
Published in PeerJ (San Francisco, CA) (22-06-2020)“…Lam. is a plant used traditionally to treat different ailments. Currently, scanty information is available on its safety. The aim of this study is to determine…”
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Evaluating the oestrogenic activities of aqueous root extract of Asparagus africanus Lam in female Sprague-Dawley rats and its phytochemical screening using Gas Chromatography-Mass Spectrometry (GC/MS)
Published in PeerJ (San Francisco, CA) (19-07-2019)“…Lam. is a plant used traditionally for natal care. This study evaluates the oestrogenic activities of aqueous root extract and screens for possible bioactive…”
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Conflicting reports on the role of the glycemic effect of Catha edulis (Khat): A systematic review and meta-analysis
Published in Journal of ethnopharmacology (20-06-2016)“…Traditionally, the leaves of Catha edulis Forsskal (Khat) are consumed by the people of Yemen primarily for its recreational effect, and secondarily, for…”
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Adipocytokine Regulation and Antiangiogenic Activity Underlie the Molecular Mechanisms of Therapeutic Effects of Phyllanthus niruri against Non-Alcoholic Fatty Liver Disease
Published in Nutrients (09-08-2018)“…The growth of adipose tissues is considered angiogenesis-dependent during non-alcoholic fatty liver disease (NAFLD). We have recently reported that our…”
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Evaluation of chemopreventive effects of Acanthus ilicifolius against azoxymethane-induced aberrant Crypt Foci in the rat colon
Published in PloS one (12-05-2014)“…Acanthus ilicifolius, a mangrove medicinal plant, is traditionally used to treat a variety of diseases. The aim of this research is to assess the…”
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Free radical scavenging, antimicrobial and immunomodulatory activities of Orthosiphon stamineus
Published in Molecules (Basel, Switzerland) (08-05-2012)“…Orthosiphon stamineus is considered an important traditional folk medicine. In this study ethanol and aqueous extracts of O. stamineus were evaluated in vitro…”
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Immune stimulatory effect of Nigella sativa in healthy animal models: A systematic review and meta-analysis
Published in Heliyon (30-03-2024)“…The immune-modulatory effects of black seeds (Nigella sativa seeds, NSS) are well documented, but the overall in vivo impact of this important natural…”
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Acute toxicity evaluation, antibacterial, antioxidant and immunomodulatory effects of Melastoma malabathricum
Published in Molecules (Basel, Switzerland) (20-03-2012)“…Melastoma malabathricum (MM) is a well-known plant in Malaysian traditional medicine, locally known as senduduk. Its ethanol and aqueous extracts have been…”
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Cynometra cauliflora Linn. Attenuates metabolic abnormalities in high-fat diet-induced obese mice
Published in Journal of ethnopharmacology (23-05-2019)“…Cynometra cauliflora Linn. belongs to the Fabaceae family and is known locally in Malaysia as nam-nam. Traditionally, a decoction of the C. cauliflora leaves…”
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Targeted polymeric nanoparticle for anthracycline delivery in hypoxia-induced drug resistance in metastatic breast cancer cells
Published in Anti-cancer drugs (01-08-2021)“…Poly lactic-co-glycolic acid (PLGA) nanoparticles are intensively studied nanocarriers in drug delivery because of their biodegradability and biochemical…”
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Investigation into the Molecular Mechanisms underlying the Anti-proliferative and Anti-tumorigenesis activities of Diosmetin against HCT-116 Human Colorectal Cancer
Published in Scientific reports (26-03-2019)“…Diosmetin (Dis) is a bioflavonoid with cytotoxicity properties against variety of cancer cells including hepatocarcinoma, breast and colorectal (CRC) cancer…”
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Antiproliferative and apoptotic activities of 8-prenylnaringenin against human colon cancer cells
Published in Life sciences (1973) (01-09-2019)“…The compound 8-prenylnaringenin (8-PN) is a prenylflavonoid that can be isolated from hops and beer and has anti-cancer properties against breast cancer. The…”
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Evaluation of pharmacokinetics and blood-brain barrier permeability of mitragynine using in vivo microdialysis technique
Published in Journal of pharmaceutical and biomedical analysis (05-09-2017)“…•Mitragynine is a potential drug candidate for pain control and opioid withdrawal therapy.•Pharmacokinetics properties and BBB permeability was evaluated using…”
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Mutagenicity and genotoxicity effects of Verbena officinalis leaves extract in Sprague-Dawley Rats
Published in Journal of ethnopharmacology (10-05-2019)“…Traditionally, Verbena officinalis L. has been used for reproductive and gynaecological purposes. However, the mutagenicity and genotoxicity of V. officinalis…”
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