Search Results - "Ábrahám, István M"
-
1
Estradiol-Induced Epigenetically Mediated Mechanisms and Regulation of Gene Expression
Published in International journal of molecular sciences (30-04-2020)“…Gonadal hormone 17β-estradiol (E2) and its receptors are key regulators of gene transcription by binding to estrogen responsive elements in the genome. Besides…”
Get full text
Journal Article -
2
Effect of Inflammation on Female Gonadotropin-Releasing Hormone (GnRH) Neurons: Mechanisms and Consequences
Published in International journal of molecular sciences (14-01-2020)“…Inflammation has a well-known suppressive effect on fertility. The function of gonadotropin-releasing hormone (GnRH) neurons, the central regulator of…”
Get full text
Journal Article -
3
High‐Fidelity NIR‐II Multiplexed Lifetime Bioimaging with Bright Double Interfaced Lanthanide Nanoparticles
Published in Angewandte Chemie International Edition (25-10-2021)“…Fluorescence lifetime imaging provides more possibility of in vivo multiplexing in second near infrared (NIR‐II) window. However, it still faces the obstacle…”
Get full text
Journal Article -
4
Nonclassical Estrogen Modulation of Presynaptic GABA Terminals Modulates Calcium Dynamics in Gonadotropin-Releasing Hormone Neurons
Published in Endocrinology (Philadelphia) (01-11-2008)“…There is increasing recognition that estrogen exerts multifaceted regulatory effects on GnRH neurons. The acute effects of estrogen on calcium dynamics in…”
Get full text
Journal Article -
5
Estradiol Sensitizes the Transient Receptor Potential Vanilloid 1 Receptor in Pain Responses
Published in Endocrinology (Philadelphia) (01-10-2017)“…Sex differences exist in chronic pain pathologies, and gonadal estradiol (E2) alters the pain sensation. The nocisensor transient receptor potential vanilloid…”
Get full text
Journal Article -
6
Critical in Vivo Roles for Classical Estrogen Receptors in Rapid Estrogen Actions on Intracellular Signaling in Mouse Brain
Published in Endocrinology (Philadelphia) (01-07-2004)“…Estrogen exerts classical genomic as well as rapid nongenomic actions on neurons. The mechanisms involved in rapid estrogen signaling are poorly defined, and…”
Get full text
Journal Article -
7
Live-Cell Imaging of Single Neurotrophin Receptor Molecules on Human Neurons in Alzheimer's Disease
Published in International journal of molecular sciences (09-12-2021)“…Neurotrophin receptors such as the tropomyosin receptor kinase A receptor (TrkA) and the low-affinity binding p75 neurotrophin receptor p75 play a critical…”
Get full text
Journal Article -
8
Characterization of Neurons Expressing the Novel Analgesic Drug Target Somatostatin Receptor 4 in Mouse and Human Brains
Published in International journal of molecular sciences (21-10-2020)“…Somatostatin is an important mood and pain-regulating neuropeptide, which exerts analgesic, anti-inflammatory, and antidepressant effects via its Gi…”
Get full text
Journal Article -
9
Treatment of beta amyloid 1–42 (Aβ1–42)-induced basal forebrain cholinergic damage by a non-classical estrogen signaling activator in vivo
Published in Scientific reports (16-02-2016)“…In Alzheimer’s disease (AD), there is a loss in cholinergic innervation targets of basal forebrain which has been implicated in substantial cognitive decline…”
Get full text
Journal Article -
10
The role of cAMP response element-binding protein in estrogen negative feedback control of gonadotropin-releasing hormone neurons
Published in The Journal of neuroscience (15-08-2012)“…The mechanisms through which estradiol (E2) regulates gonadotropin-releasing hormone (GnRH) neurons to control fertility are unclear. Previous studies have…”
Get full text
Journal Article -
11
Melatonin Suppresses the Kainate Receptor-Mediated Excitation on Gonadotropin-Releasing Hormone Neurons in Female and Male Prepubertal Mice
Published in International journal of molecular sciences (20-08-2020)“…Melatonin, a pineal gland secretion, is an amphiphilic neurohormone involved in the biological and physiologic regulation of bodily functions. Numerous studies…”
Get full text
Journal Article -
12
Somatostatin Inhibition of Gonadotropin-Releasing Hormone Neurons in Female and Male Mice
Published in Endocrinology (Philadelphia) (01-07-2010)“…Previous studies indicate that somatostatin regulates gonadotropin secretion. We investigated here whether somatostatin has direct effects on GnRH neurons in…”
Get full text
Journal Article -
13
Rapid non-classical effects of steroids on the membrane receptor dynamics and downstream signaling in neurons
Published in Hormones and behavior (01-08-2018)“…Contribution to Special Issue on Fast effects of steroids. Although rapid effects of steroid hormones on membrane receptors and intracellular signaling…”
Get full text
Journal Article -
14
Sex differences in rapid nonclassical action of 17β‐oestradiol on intracellular signalling and oestrogen receptor α expression in basal forebrain cholinergic neurones in mouse
Published in Journal of neuroendocrinology (01-01-2020)“…Rapid nonclassical effects of 17β‐oestradiol (E2) on intracellular signalling have been identified in the basal forebrain, although the extent to which these…”
Get full text
Journal Article -
15
Estradiol Modulation of Neurotrophin Receptor Expression in Female Mouse Basal Forebrain Cholinergic Neurons In Vivo
Published in Endocrinology (Philadelphia) (01-02-2015)“…The neuroprotective effect of estradiol (E2) on basal forebrain cholinergic neurons (BFCNs) has been suggested to occur as a result of E2 modulation of the…”
Get full text
Journal Article -
16
Super-Resolution Imaging With Lanthanide Luminescent Nanocrystals: Progress and Prospect
Published in Frontiers in bioengineering and biotechnology (30-09-2021)“…Stimulated emission depletion (STED) nanoscopy has overcome a serious diffraction barrier on the optical resolution and facilitated new discoveries on detailed…”
Get full text
Journal Article -
17
Dynamic changes in binding interaction networks of sex steroids establish their non-classical effects
Published in Scientific reports (01-11-2017)“…Non-classical signaling in the intracellular second messenger system plays a pivotal role in the cytoprotective effect of estradiol. Estrogen receptor is a…”
Get full text
Journal Article -
18
17β-estradiol does not have a direct effect on the function of striatal cholinergic interneurons in adult mice in vitro
Published in Frontiers in endocrinology (Lausanne) (04-01-2023)“…The striatum is an essential component of the basal ganglia that is involved in motor control, action selection and motor learning. The pathophysiological…”
Get full text
Journal Article -
19
Single-Molecule Imaging Reveals Rapid Estradiol Action on the Surface Movement of AMPA Receptors in Live Neurons
Published in Frontiers in cell and developmental biology (23-09-2021)“…Gonadal steroid 17β-estradiol (E2) exerts rapid, non-genomic effects on neurons and strictly regulates learning and memory through altering glutamatergic…”
Get full text
Journal Article -
20
Non-classical effects of estradiol on cAMP responsive element binding protein phosphorylation in gonadotropin-releasing hormone neurons: Mechanisms and role
Published in Frontiers in neuroendocrinology (01-01-2014)“…Highlights • Estrogens act through indirect and direct pathways to activate CREB in GnRH neurons. • CREB is essential for estrogen negative feedback on GnRH…”
Get full text
Journal Article