Search Results - "Aïkawa, Elena"

Editorial: Highlights in heart valve disease: 2021 by Elena, Aikawa

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Sortilin and Its Multiple Roles in Cardiovascular and Metabolic Diseases by Goettsch, Claudia, Kjolby, Mads, Aikawa, Elena

“…Cardiovascular disease is a leading cause of morbidity and mortality in the Western world. Studies of sortilin's influence on cardiovascular and metabolic…”
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Revised microcalcification hypothesis for fibrous cap rupture in human coronary arteries by Kelly-Arnold, Adreanne, Maldonado, Natalia, Laudier, Damien, Aikawa, Elena, Cardoso, Luis, Weinbaum, Sheldon

“…Using 2.1-µm high-resolution microcomputed tomography, we have examined the spatial distribution, clustering, and shape of nearly 35,000 microcalcifications…”
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Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques by Hutcheson, Joshua D., Goettsch, Claudia, Bertazzo, Sergio, Maldonado, Natalia, Ruiz, Jessica L., Goh, Wilson, Yabusaki, Katsumi, Faits, Tyler, Bouten, Carlijn, Franck, Gregory, Quillard, Thibaut, Libby, Peter, Aikawa, Masanori, Weinbaum, Sheldon, Aikawa, Elena

“…Clinical evidence links arterial calcification and cardiovascular risk. Finite-element modelling of the stress distribution within atherosclerotic plaques has…”
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Roles and Regulation of Extracellular Vesicles in Cardiovascular Mineral Metabolism by Blaser, Mark C, Aikawa, Elena

“…Cardiovascular calcification is a multifaceted disease that is a leading independent predictor of cardiovascular morbidity and mortality. Recent studies have…”
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Spatiotemporal Multi-Omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease by Schlotter, Florian, Halu, Arda, Goto, Shinji, Blaser, Mark C, Body, Simon C, Lee, Lang H, Higashi, Hideyuki, DeLaughter, Daniel M, Hutcheson, Joshua D, Vyas, Payal, Pham, Tan, Rogers, Maximillian A, Sharma, Amitabh, Seidman, Christine E, Loscalzo, Joseph, Seidman, Jonathan G, Aikawa, Masanori, Singh, Sasha A, Aikawa, Elena

“…BACKGROUND:No pharmacological therapy exists for calcific aortic valve disease (CAVD), which confers a dismal prognosis without invasive valve replacement. The…”
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Noninvasive Molecular Imaging of Disease Activity in Atherosclerosis by Dweck, Marc R, Aikawa, Elena, Newby, David E, Tarkin, Jason M, Rudd, James H.F, Narula, Jagat, Fayad, Zahi A

“…Major focus has been placed on the identification of vulnerable plaques as a means of improving the prediction of myocardial infarction. However, this strategy…”
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Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress by Rogers, Maximillian A, Maldonado, Natalia, Hutcheson, Joshua D, Goettsch, Claudia, Goto, Shinji, Yamada, Iwao, Faits, Tyler, Sesaki, Hiromi, Aikawa, Masanori, Aikawa, Elena

“…Mitochondrial changes occur during cell differentiation and cardiovascular disease. DRP1 (dynamin-related protein 1) is a key regulator of mitochondrial…”
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Cardiovascular Calcification: An Inflammatory Disease by New, Sophie E. P., Aikawa, Elena

“…Cardiovascular calcification is an independent risk factor for cardiovascular morbidity and mortality. This disease of dysregulated metabolism is no longer…”
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PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation by Iwata, Hiroshi, Goettsch, Claudia, Sharma, Amitabh, Ricchiuto, Piero, Goh, Wilson Wen Bin, Halu, Arda, Yamada, Iwao, Yoshida, Hideo, Hara, Takuya, Wei, Mei, Inoue, Noriyuki, Fukuda, Daiju, Mojcher, Alexander, Mattson, Peter C., Barabási, Albert-László, Boothby, Mark, Aikawa, Elena, Singh, Sasha A., Aikawa, Masanori

“…Despite the global impact of macrophage activation in vascular disease, the underlying mechanisms remain obscure. Here we show, with global proteomic analysis…”
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Myocardial Infarction Alters Adaptation of the Tethered Mitral Valve by Dal-Bianco, Jacob P., MD, Aikawa, Elena, MD, PhD, Bischoff, Joyce, PhD, Guerrero, J. Luis, BS, Hjortnaes, Jesper, MD, Beaudoin, Jonathan, MD, Szymanski, Catherine, MD, Bartko, Philipp E., MD, PhD, Seybolt, Margo M., BS, Handschumacher, Mark D., BS, Sullivan, Suzanne, BS, Garcia, Michael L., MA, Mauskapf, Adam, BA, Titus, James S., BS, Wylie-Sears, Jill, MS, Irvin, Whitney S., MS, Chaput, Miguel, MD, Messas, Emmanuel, MD, PhD, Hagège, Albert A., MD, PhD, Carpentier, Alain, MD, PhD, Levine, Robert A., MD

“…Abstract Background In patients with myocardial infarction (MI), leaflet tethering by displaced papillary muscles induces mitral regurgitation (MR), which…”
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Macrophage Heterogeneity Complicates Reversal of Calcification in Cardiovascular Tissues by Rogers, Maximillian A, Aikawa, Masanori, Aikawa, Elena

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Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles by Guix, Francesc X, Corbett, Grant T, Cha, Diana J, Mustapic, Maja, Liu, Wen, Mengel, David, Chen, Zhicheng, Aikawa, Elena, Young-Pearse, Tracy, Kapogiannis, Dimitrios, Selkoe, Dennis J, Walsh, Dominic M

“…Progressive cerebral accumulation of tau aggregates is a defining feature of Alzheimer's disease (AD). A popular theory that seeks to explain the apparent…”
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Inhibition of Bone Morphogenetic Protein Signaling Reduces Vascular Calcification and Atherosclerosis by Derwall, Matthias, Malhotra, Rajeev, Lai, Carol S, Beppu, Yuko, Aikawa, Elena, Seehra, Jasbir S, Zapol, Warren M, Bloch, Kenneth D, Yu, Paul B

“…OBJECTIVE—The expression of bone morphogenetic proteins (BMPs) is enhanced in human atherosclerotic and calcific vascular lesions. Although genetic gain- and…”
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Extracellular Vesicles As Mediators of Cardiovascular Calcification by Bakhshian Nik, Amirala, Hutcheson, Joshua D, Aikawa, Elena

“…Involvement of cell-derived extracellular particles, coined as matrix vesicles (MVs), in biological bone formation was introduced by Bonucci and Anderson in…”
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Nanoparticle PET-CT Imaging of Macrophages in Inflammatory Atherosclerosis by NAHRENDORF, Matthias, HANWEN ZHANG, HEMBRADOR, Sheena, PANIZZI, Peter, SOSNOVIK, David E, AIKAWA, Elena, LIBBY, Peter, SWIRSKI, Filip K, WEISSLEDER, Ralph

“…Macrophages participate centrally in atherosclerosis, and macrophage markers (eg, CD68, MAC-3) correlate well with lesion severity and therapeutic modulation…”
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Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease by AIKAWA, Elena, NAHRENDORF, Matthias, SOSNOVIK, David, LOK, Vincent M, JAFFER, Farouc A, AIKAWA, Masanori, WEISSLEDER, Ralph

“…Visualizing early changes in valvular cell functions in vivo may predict the future risk and identify therapeutic targets for prevention of aortic valve…”
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Attenuated Mitral Leaflet Enlargement Contributes to Functional Mitral Regurgitation After Myocardial Infarction by Marsit, Ons, Clavel, Marie-Annick, Côté-Laroche, Claudia, Hadjadj, Sandra, Bouchard, Marc-André, Handschumacher, Mark D., Clisson, Marine, Drolet, Marie-Claude, Boulanger, Marie-Chloé, Kim, Dae-Hee, Guerrero, J. Luis, Bartko, Philipp Emanuel, Couet, Jacques, Arsenault, Marie, Mathieu, Patrick, Pibarot, Philippe, Aïkawa, Elena, Bischoff, Joyce, Levine, Robert A., Beaudoin, Jonathan

“…Mitral leaflet enlargement has been identified as an adaptive mechanism to prevent mitral regurgitation in dilated left ventricles (LVs) caused by chronic…”
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Heart Valve Disease: Challenges and New Opportunities by Bartoli-Leonard, Francesca, Aikawa, Elena

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Impaired Infarct Healing in Atherosclerotic Mice With Ly-6Chi Monocytosis by Panizzi, Peter, PhD, Swirski, Filip K., PhD, Figueiredo, Jose-Luiz, MD, Waterman, Peter, BS, Sosnovik, David E., MD, Aikawa, Elena, MD, PhD, Libby, Peter, MD, Pittet, Mikael, PhD, Weissleder, Ralph, MD, PhD, Nahrendorf, Matthias, MD, PhD

“…Objectives The aim of this study was to test whether blood monocytosis in mice with atherosclerosis affects infarct healing. Background Monocytes are cellular…”
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