Search Results - "A'Hern, Roger"

Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial by Nutting, Christopher M, Dr, Morden, James P, MSc, Harrington, Kevin J, FRCR, Urbano, Teresa Guerrero, PhD, Bhide, Shreerang A, FRCR, Clark, Catharine, PhD, Miles, Elizabeth A, MPhil, Miah, Aisha B, FRCR, Newbold, Kate, FRCR, Tanay, MaryAnne, MSc, Adab, Fawzi, FRCR, Jefferies, Sarah J, FRCR, Scrase, Christopher, FRCR, Yap, Beng K, FRCR, A'Hern, Roger P, MSc, Sydenham, Mark A, BSc, Emson, Marie, BSc, Hall, Emma, PhD

“…Summary Background Xerostomia is the most common late side-effect of radiotherapy to the head and neck. Compared with conventional radiotherapy,…”
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prognostic significance of Ki67 before and after neoadjuvant chemotherapy in breast cancer by Jones, Robin L, Salter, Janine, A'Hern, Roger, Nerurkar, Ash, Parton, Marina, Reis-Filho, Jorge S, Smith, Ian E, Dowsett, Mitchell

“…Purpose To compare the prognostic significance of proliferation, as assessed by Ki67 expression, in breast cancer before and after neoadjuvant chemotherapy…”
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Suppression of Plasma Estrogen Levels by Letrozole and Anastrozole Is Related to Body Mass Index in Patients With Breast Cancer by Folkerd, Elizabeth J, Dixon, J Michael, Renshaw, Lorna, A'Hern, Roger P, Dowsett, Mitch

“…To investigate whether suppression of plasma estradiol and estrone sulfate levels by the aromatase inhibitors (AIs) anastrozole and letrozole is related to…”
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Real-time imaging of single neuronal cell apoptosis in patients with glaucoma by Cordeiro, Maria F, Normando, Eduardo M, Cardoso, M Jorge, Miodragovic, Serge, Jeylani, Seham, Davis, Benjamin M, Guo, Li, Ourselin, Sebastien, A'Hern, Roger, Bloom, Philip A

“…See Herms and Schön (doi: 10.1093/brain/awx100 ) for a scientific commentary on this article. Glaucoma is often diagnosed late when vision loss has already…”
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Poly(ADP)-Ribose Polymerase Inhibition: Frequent Durable Responses in BRCA Carrier Ovarian Cancer Correlating With Platinum-Free Interval by FONG, Peter C, YAP, Timothy A, A'HERN, Roger, TUTT, Andrew, ASHWORTH, Alan, STONE, John, CARMICHAEL, James, SCHELLENS, Jan H. M, DE BONO, Johann S, KAYE, Stan B, BOSS, David S, CARDEN, Craig P, MERGUI-ROELVINK, Marja, GOURLEY, Charlie, DE GREVE, Jacques, LUBINSKI, Jan, SHANLEY, Susan, MESSIOU, Christina

“…Selective tumor cell cytotoxicity can be achieved through a synthetic lethal strategy using poly(ADP)-ribose polymerase (PARP) inhibitor therapy in BRCA1/2…”
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Breast cancer molecular profiling with single sample predictors: a retrospective analysis by Weigelt, Britta, PhD, Mackay, Alan, BSc, A'hern, Roger, MSc, Natrajan, Rachael, PhD, Tan, David SP, MD, Dowsett, Mitch, Prof, Ashworth, Alan, Prof, Reis-Filho, Jorge S, Dr

“…Summary Background Microarray expression profiling classifies breast cancer into five molecular subtypes: luminal A, luminal B, basal-like, HER2, and normal…”
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Molecular Profiling of Aromatase Inhibitor―Treated Postmenopausal Breast Tumors Identifies Immune-Related Correlates of Resistance by DUNBIER, Anita K, GHAZOUI, Zara, ANDERSON, Helen, SALTER, Janine, NERURKAR, Ashutosh, OSIN, Peter, A'HERN, Roger, MILLER, William R, SMITH, Ian E, DOWSETT, Mitch

“…Estrogen withdrawal by treatment with aromatase inhibitors is the most effective form of endocrine therapy for postmenopausal estrogen receptor-positive (ER+)…”
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Prognostic Value of Ki67 Expression After Short-Term Presurgical Endocrine Therapy for Primary Breast Cancer by Dowsett, Mitch, Smith, Ian E., Ebbs, Stephen R., Dixon, J. Michael, Skene, Anthony, A'Hern, Roger, Salter, Janine, Detre, Simone, Hills, Margaret, Walsh, Geraldine

“…Tumor expression of the proliferation antigen Ki67 is widely used to assess the prognosis of cancer patients. A change in the expression of Ki67 after…”
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Letrozole Suppresses Plasma Estradiol and Estrone Sulphate More Completely Than Anastrozole in Postmenopausal Women With Breast Cancer by DIXON, J. Michael, RENSHAW, Lorna, YOUNG, Oliver, MURRAY, Juliette, MACASKILL, E. Jane, MCHUGH, Mary, FOLKERD, Elizabeth, CAMERON, David A, A'HERN, Roger P, DOWSETT, Mitch

“…To compare the effects of anastrozole and letrozole on plasma estradiol (E2) and estrone sulfate (E1S) levels. Fifty-four postmenopausal women with estrogen…”
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Residual DNA and chromosomal damage in ex vivo irradiated blood lymphocytes correlated with late normal tissue response to breast radiotherapy by Chua, Melvin Lee Kiang, Somaiah, Navita, A’Hern, Roger, Davies, Sue, Gothard, Lone, Yarnold, John, Rothkamm, Kai

“…Abstract Purpose To test the association of DNA double-strand break (DSB) repair and chromosomal radiosensitivity in ex vivo irradiated blood lymphocytes with…”
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Analgesic therapy in postherpetic neuralgia: a quantitative systematic review by Hempenstall, Kathleen, Nurmikko, Turo J, Johnson, Robert W, A'Hern, Roger P, Rice, Andrew S C

“…Postherpetic neuralgia (PHN) is a complication of acute herpes zoster, which is emerging as a preferred clinical trial model for chronic neuropathic pain…”
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Adenoid cystic carcinomas constitute a genomically distinct subgroup of triple-negative and basal-like breast cancers by Wetterskog, Daniel, Lopez-Garcia, Maria Angeles, Lambros, Maryou B, A'Hern, Roger, Geyer, Felipe C, Milanezi, Fernanda, Cabral, Maria C, Natrajan, Rachael, Gauthier, Arnaud, Shiu, Kai-Keen, Orr, Nicholas, Shousha, Sami, Gatalica, Zoran, Mackay, Alan, Palacios, Jose, Reis-Filho, Jorge S, Weigelt, Britta

“…Adenoid cystic carcinoma (AdCC) is a rare form of triple‐negative and basal‐like breast cancer that has an indolent clinical behaviour. Four breast AdCCs were…”
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Correlation of in vitro lymphocyte radiosensitivity and gene expression with late normal tissue reactions following curative radiotherapy for breast cancer by Finnon, Paul, Kabacik, Sylwia, MacKay, Alan, Raffy, Claudine, A’Hern, Roger, Owen, Roger, Badie, Christophe, Yarnold, John, Bouffler, Simon

“…Abstract Background and purpose Identification of mechanisms of late normal tissue responses to curative radiotherapy that discriminate individuals with marked…”
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Synovial Sarcoma: A Clinicopathologic, Staging, and Prognostic Assessment by SPILLANE, Andrew J, AHERN, Roger, JUDSON, Ian R, FISHER, Cyril, THOMAS, J. Meirion

“…Synovial sarcoma (SS) is a common soft tissue sarcoma (STS) with a propensity for young adults and notable sensitivity to chemotherapy (CT). This study…”
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Relationship between oestrogen receptor status and proliferation in predicting response and long-term outcome to neoadjuvant chemotherapy for breast cancer by Jones, Robin L, Salter, Janine, A'Hern, Roger, Nerurkar, Ash, Parton, Marina, Reis-Filho, Jorge S, Smith, Ian E, Dowsett, Mitchell

“…Oestrogen receptor (ER) negative breast cancers are more likely to achieve a pathological complete response (pCR) to neoadjuvant chemotherapy compared to those…”
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Expression of key oestrogen-regulated genes differs substantially across the menstrual cycle in oestrogen receptor-positive primary breast cancer by Haynes, Ben P., Viale, Giuseppe, Galimberti, Viviana, Rotmensz, Nicole, Gibelli, Bianca, A’Hern, Roger, Smith, Ian E., Dowsett, Mitch

“…Plasma estradiol (E2) and progesterone vary markedly through the menstrual cycle. Data on whether these differences in hormone levels affect gene expression in…”
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Restricted Mean Survival Time: An Obligatory End Point for Time-to-Event Analysis in Cancer Trials? by A'Hern, Roger P

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Extreme loss of immunoreactive p-Akt and p-Erk1/2 during routine fixation of primary breast cancer by Pinhel, Isabel F, Macneill, Fiona A, Hills, Margaret J, Salter, Janine, Detre, Simone, A'hern, Roger, Nerurkar, Ashutosh, Osin, Peter, Smith, Ian E, Dowsett, Mitch

“…Very few studies have investigated whether the time elapsed between surgical resection and tissue fixation or the difference between core-cut and excision…”
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Patient Selection for Oncology Phase I Trials: A Multi-Institutional Study of Prognostic Factors by OLMOS, David, A'HERN, Roger P, SCHELLENS, Jan H, DEL CONTE, Gianluca, BRUNETTO, Andre T, JEFFRY EVANS, T. R, WILSON, Richard, GALLERANI, Elisa, PLUMMER, Ruth, TABERNERO, Josep, SORIA, Jean-Charles, KAYE, Stan B, MARSONI, Silvia, MORALES, Rafael, GOMEZ-ROCA, Carlos, VERWEIJ, Jaap, VOEST, Emile E, SCHÖFFSKI, Patrick, JOO ERN ANG, PENEL, Nicolas

“…The appropriate selection of patients for early clinical trials presents a major challenge. Previous analyses focusing on this problem were limited by small…”
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Intratumoral Estrogen Disposition in Breast Cancer by HAYNES, Ben P, STRAUME, Anne Hege, GEISLER, Jürgen, A'HERN, Roger, HELLE, Hildegunn, SMITH, Ian E, LØNNING, Per E, DOWSETT, Mitch

“…The concentration of estradiol (E(2)) in breast tumors is significantly higher than that in plasma, particularly in postmenopausal women. The contribution of…”
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