Search Results - ". Buckingham, J. C"

Post-translational modification plays an essential role in the translocation of annexin A1 from the cytoplasm to the cell surface by Solito, E, Christian, H.C, Festa, M, Mulla, A, Tierney, T, Flower, R.J, Buckingham, J.C

“…Annexin A1 (ANXA1) has an important role in cell-cell communication in the host defense and neuroendocrine systems. In both systems, its actions are exerted…”
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Altered Mesencephalic Dopaminergic Populations in Adulthood as a Consequence of Brief Perinatal Glucocorticoid Exposure by McArthur, S., McHale, E., Dalley, J. W., Buckingham, J. C., Gillies, G. E.

“…Early exposure to stressors is strongly associated with enduring effects on central nervous system function, but the mechanisms and neural substrates involved…”
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Evidence From In Vitro and In Vivo Studies Showing that Nuclear Factor-Kappa B Within the Pituitary Folliculostellate Cells and Corticotrophs Regulates Adrenocorticotrophic Hormone Secretion in Experimental Endotoxaemia by Mehet, D. K., Philip, J., Solito, E., Buckingham, J. C., John, C. D.

“…The hypothalamic‐pituitary‐adrenocortical (HPA) responses to bacterial infection are mediated, in part, by the actions of lipopolysaccharide (LPS) on pituitary…”
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Perinatal Glucocorticoid Treatment Produces Molecular, Functional, and Morphological Changes in the Anterior Pituitary Gland of the Adult Male Rat by Theogaraj, E, John, C. D, Christian, H. C, Morris, J. F, Smith, S. F, Buckingham, J. C

“…Stress or glucocorticoid (GC) treatment in perinatal life can induce long-term changes in the sensitivity of the hypothalamo-pituitary-adrenocortical axis to…”
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Formyl peptide receptors and the regulation of ACTH secretion: targets for annexin A1, lipoxins, and bacterial peptides by John, C.D, Sahni, V, Mehet, D, Morris, J.F, Christian, H.C, Perretti, M, Flower, R.J, Solito, E, Buckingham, J.C

“…The N-formyl peptide receptors (FPRs) are a family of G-protein coupled receptors that respond to proinflammatory N-formylated bacterial peptides (e.g.,…”
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Kinase-Dependent Regulation of the Secretion of Thyrotrophin and Luteinizing Hormone By Glucocorticoids and Annexin 1 Peptides by John, C. D., Christian, H. C., Morris, J. F., Flower, R. J., Solito, E., Buckingham, J. C.

“…Our previous studies have identified a role for annexin 1 (ANXA1), a protein produced by the pituitary folliculostellate cells, as a paracrine/juxtacrine…”
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Perinatal Glucocorticoid Treatment Disrupts the Hypothalamo-Lactotroph Axis in Adult Female, But Not Male, Rats by McArthur, S, Siddique, Z.-L, Christian, H. C, Capone, G, Theogaraj, E, John, C. D, Smith, S. F, Morris, J. F, Buckingham, J. C, Gillies, G. E

“…This study aimed to test the hypothesis that the tuberoinfundibular dopaminergic neurons of the arcuate nucleus and/or the lactotroph cells of the anterior…”
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Stress and the neuroendocrine-immune axis : the pivotal role of glucocorticoids and lipocortin 1 by BUCKINGHAM, J. C

“…This article, will discuss the molecular mechanisms underlying the pivotal feedback actions of the glucocorticoids within the HPA axis, focusing on our recent…”
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The long-term effects of perinatal glucocorticoid exposure on the host defence system of the respiratory tract by Theogaraj, E, John, CD, Dewar, A, Buckingham, JC, Smith, SF

“…Glucocorticoids are used to mature the fetal lung at times of threatened premature delivery. These drugs modify leukocyte profiles when administered in…”
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Lack of Annexin 1 Results in an Increase in Corticotroph Number in Male but not Female Mice by Morris, J. F., Omer, S., Davies, E., Wang, E., John, C., Afzal, T., Wain, S., Buckingham, J. C., Flower, R. J., Christian, H. C.

“…Annexin 1 (ANXA1) is a member of the annexin family of phospholipid‐ and calcium‐binding proteins with a well demonstrated role in early delayed (30 min to 3…”
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Time-Specific Effects of Perinatal Glucocorticoid Treatment on Anterior Pituitary Morphology, Annexin 1 Expression and Adrenocorticotrophic Hormone Secretion in the Adult Female Rat by John, C. D., Theogaraj, E., Christian, H. C., Morris, J. F., Smith, S. F., Buckingham, J. C.

“…Perinatal glucocorticoid (GC) treatment is increasingly associated with long‐term disturbances in hypothalamo‐pituitary‐adrenocortical function. In the male…”
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The annexin-1 knockout mouse: what it tells us about the inflammatory response by Roviezzo, F, Getting, S J, Paul-Clark, M J, Yona, S, Gavins, F N E, Perretti, M, Hannon, R, Croxtall, J D, Buckingham, J C, Flower, R J

“…The 37kDa protein annexin 1 (Anx-1; lipocortin 1) is a glucocorticoid-regulated protein that has been implicated in the regulation of phagocytosis, cell…”
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FIFTEENTH GADDUM MEMORIAL LECTURE DECEMBER 1994 Stress and the neuroendocrine‐immune axis: the pivotal role of glucocorticoids and lipocortin 1 by Buckingham, J.C.

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Glucagon-like peptide-1 stimulates luteinizing hormone-releasing hormone secretion in a rodent hypothalamic neuronal cell line by Beak, S A, Heath, M M, Small, C J, Morgan, D G, Ghatei, M A, Taylor, A D, Buckingham, J C, Bloom, S R, Smith, D M

“…To examine the influence of the putative satiety factor (GLP-1) on the hypothalamo-pituitary-gonadal axis, we used GT1-7 cells as a model of neuronal…”
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Evidence From Studies on Co-Cultures of TtT/GF and AtT20 Cells That Annexin 1 Acts as a Paracrine or Juxtacrine Mediator of the Early Inhibitory Effects of Glucocorticoids on ACTH Release by Tierney, T., . Christian, H. C, . Morris, J. F, Solito, E., . Buckingham, J. C

“…Annexin 1 (ANXA1) is a key mediator of the inhibitory effects of glucocorticoids on adrenocorticotropic hormone (ACTH) release, which develop within 1–2 h of a…”
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Opposing influences of glucocorticoids and interleukin‐1β on the secretion of growth hormone and ACTH in the rat in vivo: role of hypothalamic annexin 1 by Philip, J G, John, C D, Cover, P O, Morris, J F, Christian, H C, Flower, R J, Buckingham, J C

“…This study exploited established immunoneutralization protocols and an N‐terminal annexin 1 peptide (annexin 1Ac2 – 26) to advance our knowledge of the role of…”
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Characterization and Localization of Lipocortin 1-Binding Sites on Rat Anterior Pituitary Cells by Fluorescence-Activated Cell Analysis/Sorting and Electron Microscopy by Christian, H. C., Taylor, A. D., Flower, R. J., Morris, J. F., Buckingham, J. C.

“…Abstract Lipocortin 1 (LC1) is an important mediator of glucocorticoid action in the anterior pituitary gland, where it appears to act via cell surface binding…”
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Dexamethasone inhibits the release of TSH from the rat anterior pituitary gland in vitro by mechanisms dependent on de novo protein synthesis and lipocortin 1 by Taylor, A D, Flower, R J, Buckingham, J C

“…Glucocorticoids have been shown repeatedly to inhibit the secretion of TSH in experimental animals and in man but their site and mode of action are unknown. In…”
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Evidence from immunoneutralization and antisense studies that the inhibitory actions of glucocorticoids on growth hormone release in vitro require annexin 1 (lipocortin 1) by Taylor, A D, Christian, H C, Morris, J F, Flower, R J, Buckingham, J C

“…Our previous studies have identified a role for annexin 1 as a mediator of glucocorticoid action in the neuroendocrine system. The present study centred on…”
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Steroid Effects on Secretion from Subsets of Lactotrophs: Role of Folliculo-Stellate Cells and Annexin 1 by Morris, J.F., Christian, H.C., Chapman, L.P., Epton, M.J., Buckingham, J.C., Ozawa, H., Nishi, M., Kawata, M.

“…Prolactin secretion is controlled by the hypothalamus, and by circulating steroids; oestrogens stimulate, but glucocorticoids inhibit prolactin release…”
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