동과가 streptozotocin에 의해 손상된 대뇌신경세포에 미치는 영향

It has been suggested that oxidative stress may play an important role in the pathogenesis of diabetic complications. The purpose of this study was to examine the oxidative stress of streptozotocin(STZ) in the cultured mouse cerebral neurons and the preventing effect of vitamin E and and Benincasae...

Full description

Saved in:

Bibliographic Details
Published in:	동의생리병리학회지 Vol. 16; no. 3; pp. 584 - 587
Main Authors:	이환봉(Whan Bong Lee), 이강창(Kang Chang Lee), 이기남(Ki Nam Lee), 홍기연(Gi Youn Hong), 석승한(Seung Han Suk), 조정구(Chung Cu Cho), 정선관(Seon Kwan Jung), 허정무(Jung Mu Hur), 이상복(Sang Bork Lee), 서은아(Eun A Seo), 송호준(Ho Jun Song), 이영찬(Young Chan Lee), 박승택(Seung Taeck Park)
Format:	Journal Article
Language:	Korean
Published:	한의병리학회 2002
Subjects:	Benincasae Semen Antioxidant Cultured mouse cerebral neuron
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	It has been suggested that oxidative stress may play an important role in the pathogenesis of diabetic complications. The purpose of this study was to examine the oxidative stress of streptozotocin(STZ) in the cultured mouse cerebral neurons and the preventing effect of vitamin E and and Benincasae Semen(BS) on STZ-induced neurotoxicity. Cytotoxic effect of STZ and neuroprotective effect of antioxidant and BS were performed by MTT assay. 30 μM STZ decreased cell viability in dose-and time-dependent mannner, and vitamin E and BS diminished STZ-induced neurotoxicity in these cultures. From above the results, STZ has toxic effect. and antioxidants, vitamin E or herb extract of BS is very effective against STZ-induced neurotoxicity in cultured cerebral neurons of neonatal mouse.
Bibliography:	KISTI1.1003/JNL.JAKO200217140951736
ISSN:	1738-7698 2288-2529 2283-2529