원지 추출물의 랫드에서 2주 반복 경구투여 독성평가

The objective of this study is to characterize a toxicity of Polygalae Radix (PR) in F344 rats and to find a dose levels for the 13 weeks toxicity study. PR is well known as medicinal herb in many Asian countries for treatment of expectorant, tonic, tranquillizer, antipsychotic agent and functional...

Full description

Saved in:

Bibliographic Details
Published in:	생약학회지 Vol. 46; no. 1; pp. 44 - 51
Main Authors:	한형윤(Hyoung Yun Han), 김수남(Soo Nam Kim), 양영수(Young Su Yang), 한수철(Su Cheol Han), 석지현(Ji Hyeon Seok), 노항식(Hang Sik Roh), 이종권(Jong Kwon Lee), 정자영(Ja Young Jeong), 정연우(Yeon Woo Jeong), 김정아(Jeong Ah Kim), 민병선(Byung Sun Min)
Format:	Journal Article
Language:	Korean
Published:	한국생약학회 2015
Subjects:	약학 Oral Toxicity Dose Polygalae Radix
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The objective of this study is to characterize a toxicity of Polygalae Radix (PR) in F344 rats and to find a dose levels for the 13 weeks toxicity study. PR is well known as medicinal herb in many Asian countries for treatment of expectorant, tonic, tranquillizer, antipsychotic agent and functional diet for improving memory. However, there is insufficient background information on toxicological evaluation of PR extract to support its safe use. Therefore, we conducted toxicological evaluation of this drug in compliance with OECD and KFDA guideline in this study. The extract of PR was administered orally to F344 rats at dose levels of 0, 500, 1000, 2000, 3500 and 5000 mg/kg/day for 2 weeks. Each group was composed to five male and five female rats. In the result, there were no treatment PR-related adverse changes in food consumption, hematology, clinical chemistry, urinalysis, gross finding at necropsy, organ weight examination. Four males at 5000 mg/kg/day were found dead during the treatment period. These animals showed salivation. The cause of death is still under investigation. The animals treated at 500, 1000, 2000, 3500 and 5000 mg/kg/day showed salivation and all animals at 5000 mg/kg/day exhibited lower body weight and cumulative weight gain in compared to those of control animals. Therefore, we recommend that a dose group of 3500 mg/kg/day is a highest treatment group in 13-week exposure study.
Bibliography:	KISTI1.1003/JNL.JAKO201510550514662 G704-000753.2015.46.1.001
ISSN:	0253-3073 2288-9299