콩나물 추출 이소플라본이 난소적출로 유발된 골다공증 백서의 골대사에 미치는 영향

The overall purpose of this study was to investigate the effects of level of isoflavones supplementation on bone metabolism in osteoporosis rats. The effects of level of isoflavones supplementation on calcium and osteocalcin blood level, femur/body weight, bone mineral density(BMD) and bone strength...

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Bibliographic Details
Published in:	동의생리병리학회지 Vol. 23; no. 2; pp. 426 - 432
Main Authors:	김계엽(Gye Yeop Kim), 조건식(Gun Sik Cho), 정현우(Hun Woo Chung), 김기도(Gi Do Kim), 심기철(Ki Cheol Sim), 김경윤(Kyung Yoon Kim)
Format:	Journal Article
Language:	Korean
Published:	한의병리학회 2009
Subjects:	한의학 bone mineral density(BMD) osteocalcin isoflavone osteoporosis bone strength ovariectomy
Online Access:	Get full text
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Summary:	The overall purpose of this study was to investigate the effects of level of isoflavones supplementation on bone metabolism in osteoporosis rats. The effects of level of isoflavones supplementation on calcium and osteocalcin blood level, femur/body weight, bone mineral density(BMD) and bone strength were inspected in this study. This study classified 28 of 12 weeks-old male Sprague Dawley rats which have osteoporosis caused by ovariectomy into four groups of 7 rats and made the subjects medicated them isoflavone. Group I was non-treatment after osteoporosis(control); Group II was low-dose isoflavone(20 mg/kg) feeding after osteoporosis; Group III was middle-dose isoflavone(40 mg/kg) feeding after osteoporosis; Group IV was high-dose isoflavone(80 mg/kg) feeding after osteoporosis; In the calcium and osteocalcin level as one of bone formation indexes, there was a statistically significant difference between the group II, III, IV compared to group I. In respect to the femur/body weight, there was a statistically significant difference between the group II, III, IV compared to group I. In the bone mineral density and bone strength test, there was a statistically significant difference between the group II, III, IV compared to group I. The above results suggests that isoflavone medicated is effective to prevention and treatment of osteoporosis.
Bibliography:	KISTI1.1003/JNL.JAKO200916639676004 G704-000534.2009.23.2.017
ISSN:	1738-7698 2288-2529 2283-2529