Search Results - "이근욱"

Metabolic influence on macrophage polarization and pathogenesis by Thapa, Bikash, Lee, Keunwook

“…Macrophages play an essential role not only in mediating the first line of defense but also in maintaining tissue homeostasis. In response to extrinsic factors…”
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Immune response and the tumor microenvironment: how they communicate to regulate gastric cancer by Lee, Keunwook, Hwang, Hyekyung, Nam, Ki Taek

“…Gastric cancer is the second most common cause of cancer-related death in the world. A growing body of evidence indicates that inflammation is closely…”
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Liquid Biopsy: An Emerging Diagnostic, Prognostic, and Predictive Tool in Gastric Cancer by Han, Hye Sook, Lee, Keun-Wook

“…Liquid biopsy, a minimally invasive procedure that causes minimal pain and complication risks to patients, has been extensively studied for cancer diagnosis…”
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A Phase II Trial of Nintedanib in Patients with Metastatic or Recurrent Head and Neck Squamous Cell Carcinoma (HNSCC): In-Depth Analysis of Nintendanib Arm from the KCSG HN 15-16 TRIUMPH Trial by 김규현, 임선민, 안희경, 이윤규, 이근욱, 안명주, 김범석, 김혜련, 이현우, 안호정, 김진수

“…Purpose Precision oncology approach for recurrent and metastatic head and neck squamous cell carcinoma (HNSCC) is necessary due to its dismal prognosis. We…”
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PD-L1 Testing in Gastric Cancer by the Combined Positive Score of the 22C3 PharmDx and SP263 Assay with Clinically Relevant Cut-offs by Park, Yujun, Koh, Jiwon, Na, Hee Young, Kwak, Yoonjin, Lee, Keun-Wook, Ahn, Sang-Hoon, Park, Do Joong, Kim, Hyung-Ho, Lee, Hye Seung

“…We provide a comparison between 22C3 pharmDx and SP263 assay, for evaluating programmed death ligand 1 (PD-L1) expression in advanced gastric cancer (GC)…”
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A Phase II Study of Avelumab Monotherapy in Patients with Mismatch Repair-Deficient/Microsatellite Instability-High or POLE-Mutated Metastatic or Unresectable Colorectal Cancer by Kim, Jwa Hoon, Kim, Sun Young, Baek, Ji Yeon, Cha, Yong Jun, Ahn, Joong Bae, Kim, Han Sang, Lee, Keun-Wook, Kim, Ji-Won, Kim, Tae-You, Chang, Won Jin, Park, Joon Oh, Kim, Jihun, Kim, Jeong Eun, Hong, Yong Sang, Kim, Yeul Hong, Kim, Tae Won

“…We evaluated the efficacy and safety of avelumab, an anti-PD-L1 antibody, in patients with metastatic or unresectable colorectal cancer (mCRC) with mismatch…”
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Rapamycin-resistant and torin-sensitive mTOR signaling promotes the survival and proliferation of leukemic cells by Park, Seohyun, Sim, Hyunsub, Lee, Keunwook

“…The serine/threonine kinase mTOR is essential for the phosphoinositide 3-kinases (PI3K) signaling pathway, and regulates the development and function of immune…”
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Effect of Platinum-Based Chemotherapy on PD-L1 Expression on Tumor Cells in Non-small Cell Lung Cancer by Shin, Junghoon, Chung, Jin-Haeng, Kim, Se Hyun, Lee, Kyu Sang, Suh, Koung Jin, Lee, Ji Yun, Kim, Ji-Won, Lee, Jeong-Ok, Kim, Jin-Won, Kim, Yu-Jung, Lee, Keun-Wook, Kim, Jee Hyun, Bang, Soo-Mee, Lee, Jong-Seok

“…Programmed death-1 (PD-1)/PD-1 ligand (PD-L1) axis blockades have revolutionized the treatment of advanced non-small cell lung cancer (NSCLC). We assessed the…”
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Analysis of Response and Progression Patterns of Tyrosine Kinase Inhibitors in Recurrent or Metastatic Adenoid Cystic Carcinoma: A Post Hoc Analysis of Two KCSG Phase II Trials by Kim, Youjin, Keam, Bhumsuk, Kang, Eun Joo, Kim, Jin-Soo, Kim, Hye Ryun, Lee, Keun-Wook, Kwon, Jung Hye, Lee, Kyoung Eun, Yang, Yaewon, Choi, Yoon Hee, Kim, Min Kyoung, Ji, Jun Ho, Yun, Tak, Choi, Moon Young, Lee, Ki Hyeong, Kim, Sung-Bae, Ahn, Myung-Ju

“…In this study, we evaluated 66 patients diagnosed with adenoid cystic carcinoma (ACC) enrolled in two Korean Cancer Study Group trials to investigate the…”
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Longitudinal Comparative Analysis of Circulating Tumor DNA and Matched Tumor Tissue DNA in Patients with Metastatic Colorectal Cancer Receiving Palliative First-Line Systemic Anti-Cancer Therapy by Lee, Seung-Been, Kim, Ji-Won, Kim, Hong-Geun, Hwang, Sung-Hyun, Kim, Kui-Jin, Lee, Ju Hyun, Seo, Jeongmin, Kang, Minsu, Jung, Eun Hee, Suh, Koung Jin, Kim, Se Hyun, Kim, Jin Won, Kim, Yu Jung, Kim, Jee Hyun, Kwon, Nak-Jung, Lee, Keun-Wook

“…This study aimed to compare tumor tissue DNA (ttDNA) and circulating tumor DNA (ctDNA) to explore the clinical applicability of ctDNA and to better understand…”
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Decursinol Angelate Ameliorates Dextran Sodium Sulfate-Induced Colitis by Modulating Type 17 Helper T Cell Responses by Thapa, Bikash, Pak, Seongwon, Kwon, Hyun-Joo, Lee, Keunwook

“…Angelica gigas has been used as a Korean traditional medicine for pain relief and gynecological health. Although the extracts are reported to have an…”
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Adjuvant Chemotherapy in Microsatellite Instability-High Gastric Cancer by Kim, Jin Won, Cho, Sung-Yup, Chae, Jeesoo, Kim, Ji-Won, Kim, Tae-Yong, Lee, Keun-Wook, Oh, Do-Youn, Bang, Yung-Jue, Im, Seock-Ah

“…Microsatellite instability (MSI) status may affect the efficacy of adjuvant chemotherapy in gastric cancer. In this study, the clinical characteristics of…”
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Outcomes and Biomarkers of Immune Checkpoint Inhibitor Therapy in Patients with Refractory Head and Neck Squamous Cell Carcinoma: KCSG HN18-12 by Lee, Yun-Gyoo, Chang, Hyun, Keam, Bhumsuk, Chun, Sang Hoon, Park, Jihyun, Park, Keon Uk, Shin, Seong Hoon, An, Ho Jung, Lee, Kyoung Eun, Lee, Keun-Wook, Kim, Hye Ryun, Kim, Sung-Bae, Ahn, Myung-Ju, Hwang, In Gyu

“…This study was conducted to determine the effectiveness of immune checkpoint inhibitors (ICIs) in recurrent or metastatic head and neck squamous cell carcinoma…”
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A Phase 1b/2a Study of GC1118 with 5-Fluorouracil, Leucovorin and Irinotecan (FOLFIRI) in Patients with Recurrent or Metastatic Colorectal Cancer by Lee, Keun-Wook, Han, Sae-Won, Kim, Tae Won, Ahn, Joong Bae, Baek, Ji Yeon, Cho, Sang Hee, Lee, Howard, Kim, Jin Won, Kim, Ji-Won, Kim, Tae-You, Hong, Yong Sang, Beom, Seung-Hoon, Cha, Yongjun, Choi, Yoonjung, Kim, Seonhui, Bang, Yung-Jue

“…GC1118 is a novel antibody targeting epidermal growth factor receptor (EGFR) with enhanced blocking activity against both low- and high-affinity EGFR ligands…”
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Genomic and Transcriptomic Characterization of Gastric Cancer with Bone Metastasis by Oh, Sujin, Nam, Soo Kyung, Lee, Keun-Wook, Lee, Hye Seung, Park, Yujun, Kwak, Yoonjin, Lee, Kyu Sang, Kim, Ji-Won, Kim, Jin Won, Kang, Minsu, Park, Young Suk, Ahn, Sang-Hoon, Suh, Yun-Suhk, Park, Do Joong, Kim, Hyung Ho

“…Bone metastasis (BM) adversely affects the prognosis of gastric cancer (GC). We investigated molecular features and immune microenvironment that characterize…”
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CD11b Deficiency Exacerbates Methicillin-Resistant Staphylococcus aureus -Induced Sepsis by Upregulating Inflammatory Responses of Macrophages by Sim, Hyunsub, Jeong, Daecheol, Kim, Hye-In, Pak, Seongwon, Thapa, Bikash, Kwon, Hyung-Joo, Lee, Keunwook

“…Macrophages are important for the first line of defense against microbial pathogens. Integrin CD11b, which is encoded by , is expressed on the surface of…”
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A Phase 3 Randomized Clinical Trial to Compare Efficacy and Safety between Combination Therapy and Monotherapy in Elderly Patients with Advanced Gastric Cancer (KCSG ST13-10) by Lee, Keun-Wook, Zang, Dae Young, Ryu, Min-Hee, Han, Hye Sook, Kim, Ki Hyang, Kim, Mi-Jung, Koh, Sung Ae, Lee, Sung Sook, Koo, Dong-Hoe, Ko, Yoon Ho, Sohn, Byeong Seok, Kim, Jin Won, Park, Jin Hyun, Nam, Byung-Ho, Choi, In Sil

“…This study evaluated whether combination therapy is more effective than monotherapy in elderly patients with metastatic or recurrent gastric cancer (MRGC) as…”
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Gomisin G Inhibits the Growth of Triple-Negative Breast Cancer Cells by Suppressing AKT Phosphorylation and Decreasing Cyclin D1 by Maharjan, Sony, Park, Byoung Kwon, Lee, Su In, Lim page, Yoongho, Lim, Yoonho, Lee, Keunwook, Kwon, Hyung-Joo

“…A type of breast cancer with a defect in three molecular markers such as the estrogen receptor, progesterone receptor, and human epidermal growth factor…”
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Tat-indoleamine 2,3-dioxygenase 1 elicits neuroprotective effects on ischemic injury by Park, Jung Hwan, Kim, Dae Won, Shin, Min Jea, Park, Jinseu, Han, Kyu Hyung, Lee, Keun Wook, Park, Jong Kook, Choi, Yeon Joo, Yeo, Hyeon Ji, Yeo, Eun Ji, Sohn, Eun Jeong, Kim, Hyoung-Chun, Shin, EunJoo, Cho, Sung-Woo, Kim, Duk-Soo, Cho, Yong-Jun, Eum, Won Sik, Choi, Soo Young

“…It is well known that oxidative stress participates in neuronal cell death caused production of reactive oxygen species (ROS). The increased ROS is a major…”
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Impact of Patient Sex on Adverse Events and Unscheduled Utilization of Medical Services in Cancer Patients Undergoing Adjuvant Chemotherapy: A Multicenter Retrospective Cohort Study by Choi, Songji, Seo, Seyoung, Lee, Ju Hyun, Suh, Koung Jin, Kim, Ji-Won, Kim, Jin Won, Kim, Se Hyun, Kim, Yu Jung, Lee, Keun-Wook, Kim, Jwa Hoon, Kim, Tae Won, Hong, Yong Sang, Kim, Sun Young, Kim, Jeong Eun, Kim, Sang-We, Lee, Dae Ho, Lee, Jae Cheol, Choi, Chang-Min, Yoon, Shinkyo, Koh, Su-Jin, Min, Young Joo, Ahn, Yongchel, Kim, Hwa Jung, Baek, Jin Ho, Park, Sook Ryun, Kim, Jee Hyun

“…The female sex is reported to have a higher risk of adverse events (AEs) from cytotoxic chemotherapy. Few studies examined the sex differences in AEs and their…”
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