보라밸리 감자 품종의 에탄올 추출물의 비만 및 고지혈증 억제효능

This experimental study was performed to evaluate the effects of ethanol extract of purple solanum tuberosum L. cv. Bora valley (EPSTL) on obesity and hyperlipidemia in rats induced by high fat diet. Sprague-Dawley rats were divided into normal group, control group, EPSTL (100 mg/kg and 200 mg/kg) t...

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Published in:	동의생리병리학회지 Vol. 21; no. 3; pp. 605 - 610
Main Authors:	윤성수(Sung Soo Yoon), 이연희(Yun Hee Rhee), 이은옥(Eun Ok Lee), 이효정(Hyo Jung Lee), 장유성(Yu Sung Jang), 이근성(Keun Sung Lee), 원숙현(Sook Hyun Won), 임학태(Hak Tae Lim), 최종원(Jong Won Choi), 김성훈(Sung Hoon Kim)
Format:	Journal Article
Language:	Korean
Published:	한의병리학회 01-06-2007
Subjects:	한의학
Online Access:	Get full text
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Summary:	This experimental study was performed to evaluate the effects of ethanol extract of purple solanum tuberosum L. cv. Bora valley (EPSTL) on obesity and hyperlipidemia in rats induced by high fat diet. Sprague-Dawley rats were divided into normal group, control group, EPSTL (100 mg/kg and 200 mg/kg) treated group. EPSTL was orally administered to the obese rats by high fat diet for 6 weeks. The effect of EPSTL on obesity and hyperlipidemia were examined in vitro and in vivo as follows : EPSTL effectively inhibited the differentiation of 3T3-L1 adipocytes in a concentration dependent manner. EPSTL significantly lowered body weight of rats fed high fat diet for 6 weeks from 4 weeks treatment compared with untreated control. EPSTL significantly reduced the weight of retroperitoneal fat only at 100 mg/kg and epididymal fat pad in rats fed high fat diet for 4 weeks at 100 and 200 mg/kg. EPSTL significantly reduced the level of triglyceride at 200 mg/kg, while EPSTL tended to lower the levels of total lipid and phospholipid in rats fed high fat diet for 4 weeks with no significance. EPSTL significantly attenuated the level of total cholesterol, LDL and atherosclerosis index (AI) as well as increased the level of HDL at 200 mg/kg. EPSTL significantly reduced the levels of total lipid and triglyceride of hepatic tissues in rats fed high fat diet for 4 weeks at 200 mg/kg. EPSTL significantly lowered the level of insulin, while it did not affect leptin compared with untreated control. Taken together, these results suggest that EPSTL can be used for the treatment or prevention of hyperlipidemia and obesity. KCI Citation Count: 0
Bibliography:	G704-000534.2007.21.3.031
ISSN:	1738-7698 2288-2529