Cyclophosphamide에 의한 면역저하 동물모델에서 블루베리 효모 발효 분말의 면역증강 효과

Cyclophosphamide에 의한 면역저하 동물모델에서 블루베리 효모 발효 분말의 면역증강 효과

Current studies have been reported that fruits such as berries may contain both antioxidant and antitumor polyphenols that may be important in this regard. We investigated the immunostimulatory effect of fermented blueberry (Vaccinium corymbosum L.) on cyclophosphamide-induced immunosuppression in a...

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Published in:동의생리병리학회지 Vol. 33; no. 1; pp. 48 - 55
Main Authors: 정도연(Do Youn Jeong ), 양희종(Hee Jong Yang ), 정수지(Su Ji Jeong), 김민국(Min Guk Kim), 윤지영(Chi Young Yun), 이학용(Hak Yong Lee), 이양희(Yang Hee Lee), 신동엽(Dong Yeop Shin), 양예진(Yea gin Yang), 이해성(Hae Seong Lee), 박영미(Young Mi Park)
Format: Journal Article
Language:Korean
Published: 한의병리학회 2019
Subjects:
한의학
Cyclophosphamide
Immunomodulatory effect
Cytokines
Dietary immunostimulator
Blueberry
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Summary:Current studies have been reported that fruits such as berries may contain both antioxidant and antitumor polyphenols that may be important in this regard. We investigated the immunostimulatory effect of fermented blueberry (Vaccinium corymbosum L.) on cyclophosphamide-induced immunosuppression in animal model. Rats were administered blueberry yeast fermented powder (BYFP) at doses 30, 100, and 300 mg/kg for 4 weeks after cyclophosphamide (Cy) treatment, respectively. The immunomodulatory effect of BYFP were measured both in vitro and in vivo, and the changes of blood components were also analyzed. We found that BYFP recovered immunosuppression-mediated decreased liver, spleen, and thymus weights as well as up regulation of white blood cell, lymphocyte, and neutrophil in blood. Moreover, BYFP up-regulated IL-2, TNF-${\alpha}$, and IFN-${\gamma}$ pro-inflammatory cytokine production compared to immune suppressed control group, respectively. According to histological studies, BYFP regenerated significantly on Cy-mediated injured spleen at the high doses (BYFP 300) comparison with Cy-treated groups (immunosuppression). Collectively, these findings suggest that BYFP may have the potential as a dietary immunostimulatory agent.
Bibliography:KISTI1.1003/JNL.JAKO201914439302531
https://kmpath.jams.or.kr
ISSN:1738-7698
2288-2529
2283-2529
DOI:10.15188/kjopp.2019.02.33.1.48