백두옹 추출물이 Streptococcus mutans의 비수용성 글루칸형성 및 부착억제에 미치는 영향

백두옹 추출물이 Streptococcus mutans의 비수용성 글루칸형성 및 부착억제에 미치는 영향

Streptococcus mutans plays a virtal role in trigering dental caries establishment due to its ability to synthesize two significant factors. The two factors are organic acids and glucans. The former demineralized dental enamel and the latter mediates the attachment of bacteria to tooth surface. It is...

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Published in:동의생리병리학회지 Vol. 30; no. 1; pp. 27 - 32
Main Authors: 김강주(Kang Ju Kim), 박복임(Bog Im Park), 민재홍(Jae Hong Min), 채민석(Min Suk Chae), 임재유(Jae You Lim), 손혁진(Hyeok Jin Son), 이기훈(Gi Hoon Lee), 안소연(So Youn An), 전병훈(Byung Hun Jeon), 최나영(Na Young Choi), 유용욱(Yong Ouk You)
Format: Journal Article
Language:Korean
Published: 한의병리학회 2016
Subjects:
한의학
Radix Pulsatillae
Glucan
Dental caries
Bacteria
Adhesion
Streptococcus mutans
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Summary:Streptococcus mutans plays a virtal role in trigering dental caries establishment due to its ability to synthesize two significant factors. The two factors are organic acids and glucans. The former demineralized dental enamel and the latter mediates the attachment of bacteria to tooth surface. It is believed that demineralization of dental enamel and attachment of bacteria are the crucial events that indicate and develop dental caries. For this reason, we studied the effect of the ethanol extracts of Radix Pulsatillae on the growth and acid production of S. mutans. Ethanol extracts of the Radix Pulsatillae showed concentration dependent inhibitory activity against the growth and acid production of S. mutans, and produced significant inhibition compared to the control groups (p<0.05). The extracts inhibited S. mutans adherence to hydroxyapatite treated with saliva, and cell adherence was repressed by Radix Pulsatillae. the ethanol extract of Radix Pulsatillae showed remarkable inhibition of glucosyltransferase, which synthesizes water insoluble glucan form sucrose. Phytochemical analysis showed Radix Pulsatillae contained major components such as phenolic compounds, glycosides, steroids, terpenoid, and saponin. These results suggest that Radix Pulsatillae may have anti-cariogenic properties, which may be related with major components such as phenolic compounds, glycosides, steroids, terpenoid, and saponin.
Bibliography:KISTI1.1003/JNL.JAKO201612037200577
http://www.hantopic.com/kjopp/KJOPP.htm
G704-000534.2016.30.1.008
ISSN:1738-7698
2288-2529
2283-2529
DOI:10.15188/kjopp.2016.02.30.1.27