조구등이 Glucose Oxidase로 손상된 대뇌신경세포에 미치는 효과

To examine the cytotoxic effect of glucose oxidase(GO) in cultured mouse cerebral neurons, cytotoxicity was measured by MTT assay after cultured nerve cells were incubated for 3 hours in the media containing 1 ～ 60mU/ml concentrations of GO. In addition, the neuroprotective effect of Ramulus et uncu...

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Bibliographic Details
Published in:	동의생리병리학회지 Vol. 16; no. 5; pp. 1016 - 1019
Main Authors:	김형수(Hyeong Soo Kim), 이용석(Yong Suk Lee), 오석규(Suk Kyu Oh), 이강창(Kang Chang Lee), 이건목(Geon Mok Lee), 이정(Jeong Lee), 이상복(Sang Bork Lee), 김종호(Jong Ho Kim), 유준기(Jun Ki Yu), 강영성(Young Seong Kang), 김성수(Sung Soo Kim), 송호준(Ho Jun Song), 박승택(Seung Taeck Park)
Format:	Journal Article
Language:	Korean
Published:	한의병리학회 2002
Subjects:	Neuroprotective effect Ramulus et uncus uncariae Cultured cerebral neuron
Online Access:	Get full text
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Summary:	To examine the cytotoxic effect of glucose oxidase(GO) in cultured mouse cerebral neurons, cytotoxicity was measured by MTT assay after cultured nerve cells were incubated for 3 hours in the media containing 1 ～ 60mU/ml concentrations of GO. In addition, the neuroprotective effect of Ramulus et uncus uncariae(REUU) was determined by MTT assay in these cultrures. Cell viability was remarkably decreased in a dose- and time-dependent manner after cultured mouse cerebral neurons were exposed to 30mU/ml GO for 3 hours. In the neuroprotective effect of REUU on GO-induced toxicity, REUU blocked the GO-mediated neurotoxicity in these cultures. From above the results, it suggests that GO is toxic in cultured mouse cerebral neurons and selective herb extract such as REUU is effective in prevetion of the neurotoxicity induced by GO.
Bibliography:	KISTI1.1003/JNL.JAKO200217140948117
ISSN:	1738-7698 2288-2529 2283-2529