고지방/고콜레스테롤 식이 랫트 모델에서 홍삼에 의한 고중성지방혈증 개선 효과

Korean Red Ginseng (RG) are used as a traditional treatment for improve blood circulation. This experimental study was designed to investigate the inhibitory effects of Korean red ginseng on lipid metabolism in high fat/cholesterol diet (HFCD)-induced hypertriglyceridemia. Sprague Dawley rats were f...

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Published in:	동의생리병리학회지 Vol. 32; no. 1; pp. 43 - 50
Main Authors:	김혜윰(Hye Yoom Kim), 김현준(Xian Jun Jin), 홍미현(Mi Hyeon Hong), 고선미(Seon Mi Ko), 황승미(Seung Mi Hwang), 임동중(Dong joong Im), 안유미(You Mee Ahn), 이호섭(Ho Sub Lee), 강대길(Dae Gill Kang), 이윤정(Yun Jung Lee)
Format:	Journal Article
Language:	Korean
Published:	한의병리학회 2018
Subjects:	한의학 Korean Red Ginseng Triglyceride synthesis Triglyceride Metabolism Hypertriglyceridemia
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Summary:	Korean Red Ginseng (RG) are used as a traditional treatment for improve blood circulation. This experimental study was designed to investigate the inhibitory effects of Korean red ginseng on lipid metabolism in high fat/cholesterol diet (HFCD)-induced hypertriglyceridemia. Sprague Dawley rats were fed the HFCD diet with/without fluvastatin (Flu, positive control) 3 mg/kg/day, and RG 125 or 250 mg/kg/day, respectively. All groups received regular diet or HFCD diet, respectively, for 13 weeks. The last three groups treatment of Flu and RG 125, and RG 250 orally for a period of 9 weeks. Group 1, reular diet; group 2, HFCD diet; group 3, Flu + HFCD diet; group 4, RG 125 + HFCD diet; group 5, RG 250 + HFCD diet. As a result, treatment with low or high doses of RG markedly attenuated plasma levels of triglycerides and augmented plasma levels of high-density lipoprotein (HDL) in HFCD-fed rats. RG and Flu also led to an increase in lipoprotein lipase activity in the HFCD group. On the other hand, RG and Flu led to an decrease in fatty acid synthase and free fatty acid activity in the HFCD group. Treatment with RG suppressed increased expressions of $PPAR-{\alpha}$ and AMPK in HFCD rat liver or muscle. In addition, the RG attenuated triglyceridemia by inhibition of $PPAR-{\gamma}$ and FABP protein expression levels and LXR and SREBP-1 gene expression in liver or muscle. The RG significantly prevented the development of the metabolic disturbances such as hypertriglyceridemia and hyperlipidemia. Taken together, the administration of RG improves hypertriglyceridemia through the alteration in suppression of triglyceride synthesis and accentuated of triglyceride decomposition. These results suggested that RG is useful in the prevention or treatment of hypertriglyceridemia.
Bibliography:	KISTI1.1003/JNL.JAKO201810256454739 https://kmpath.jams.or.kr
ISSN:	1738-7698 2288-2529 2283-2529
DOI:	10.15188/kjopp.2018.02.32.1.43