Antidepressant effect of StillenTM

StillenTM has been used to treat patients withgastric mucosal ulcers and has an anti-inflammatory effect. It is well-known that neuro-inflammatory reactions arerelated to depression. Here we evaluated the antidepressant-like effect of StillenTM on mice subjected to the forcedswimming test (FST). Sti...

Full description

Saved in:

Bibliographic Details
Published in:	Archives of pharmacal research pp. 1223 - 1231
Main Authors:	정현자, 김정화, 김나래, 유명숙, 남선영, 김규업, 최영진, 장재범, 강인철, 백남인, 김형민
Format:	Journal Article
Language:	English
Published:	대한약학회 01-06-2015
Subjects:	약학
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	StillenTM has been used to treat patients withgastric mucosal ulcers and has an anti-inflammatory effect. It is well-known that neuro-inflammatory reactions arerelated to depression. Here we evaluated the antidepressant-like effect of StillenTM on mice subjected to the forcedswimming test (FST). StillenTM and eupatilin (a majorcomponent of StillenTM) significantly decreased immobilitytimes compared with the FST control group. In theStillenTM-administered group, increased levels of5-hydroxytryptamine (serotonin) and brain-derived neurotrophicfactor protein were observed in the hippocampus. Nissl bodies also increased in the hippocampus neuronalcytoplasm of the StillenTM-administered group. StillenTMdecreased levels of interleukin (IL)-1b, IL-6, and tumornecrosis factor-a (at the mRNA and protein levels) in thehippocampus and serum, compared with the control group. In addition, the mRNA expression of estrogen receptor-bincreased after StillenTM administration in the hippocampus. These findings suggest that StillenTM should beviewed as a candidate antidepressant. KCI Citation Count: 18
Bibliography:	G704-000010.2015.38.6.040
ISSN:	0253-6269 1976-3786