HaCaT 각질형성세포에서 홍조류인 단박(Ceramium boydenii)의 STAT1 활성 억제를 통한 MDC/CCL22 생성 억제 효과

Ceramium boydenii belongs to euphorbia humitusa of red algae, and is distributed along the coast of Jeju island. This study was conducted to examine the anti-inflammatory effect and action mechanism of C. boydenii in the human keratinocyte cell line HaCaT. The 80% EtOH extract of C. boydenii inhibit...

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Bibliographic Details
Published in:	생약학회지 Vol. 44; no. 2; pp. 154 - 160
Main Authors:	한상철(Sang Chul Han), 현은아(Eun A Hyun), 구동환(Dong Hwan Koo), 고영상(Young Sang Koh), 고미희(Mi Hee Ko), 현진원(Jin Won Hyun), 강희경(Hee Kyoung Kang), 유은숙(Eun Sook Yoo), 강나진(Na Jin Kang), 강경진(Gyeung Jin Kang)
Format:	Journal Article
Language:	Korean
Published:	한국생약학회 2013
Subjects:	약학 STAT1 Ceramium boydenii MDC HaCaT
Online Access:	Get full text
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Summary:	Ceramium boydenii belongs to euphorbia humitusa of red algae, and is distributed along the coast of Jeju island. This study was conducted to examine the anti-inflammatory effect and action mechanism of C. boydenii in the human keratinocyte cell line HaCaT. The 80% EtOH extract of C. boydenii inhibits the production of MDC (macrophage derived chemokine), an inflammatory chemokine, induced by IFN-${\gamma}$ and TNF-${\alpha}$ in a concentration dependent manner. It also suppressed the phosphorylation and nuclear translocation of STAT1, a key transcription factor in IFN-${\gamma}$ and TNF-${\alpha}$ signaling pathway, at the effective concentrations. These results suggest that C. boydenii demonstrates the anti-inflammatory activity via the suppression of STAT1 activation and has the significant value as an anti-inflammatory source.
Bibliography:	KISTI1.1003/JNL.JAKO201319953222204 G704-000753.2013.44.2.004
ISSN:	0253-3073 2288-9299