基于生物信息学预测的番鸭细小病毒和鹅细小病毒免疫交叉反应研究
通过生物信息学软件开展了基于表位预测的番鸭细小病毒（MDPV）和鹅细小病毒（GPV）免疫交叉反应研究。番鸭细小病毒非结构蛋白线性抗原表位预测结果表明：AA248~252、503~509和545~554可能是线性表位优势区域,与已知的鹅细小病毒非结构蛋白线性抗原表位区进行比较,可能具有交叉反应性的区段为AA503~509。番鸭细小病毒衣壳蛋白线性抗原表位预测结果表明：肽段AA27~33、39~50、67~75、111~115、149~155、260~264、321~325、426~430、448~452、485~489、521~525、540~544和685~691等区域可能是线性表位优势区域,...
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| Published in: | 广东农业科学 Vol. 38; no. 24; pp. 120 - 121 |
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| Main Author: | |
| Format: | Journal Article |
| Language: | Chinese |
| Published: |
齐齐哈尔大学计算机与控制工程学院,黑龙江齐齐哈尔,161006%齐齐哈尔大学生命科学与农林学院,黑龙江齐齐哈尔,161006%河北大学生命科学学院,河北保定,071002
2011
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| Online Access: | Get full text |
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| Summary: | 通过生物信息学软件开展了基于表位预测的番鸭细小病毒（MDPV）和鹅细小病毒（GPV）免疫交叉反应研究。番鸭细小病毒非结构蛋白线性抗原表位预测结果表明：AA248~252、503~509和545~554可能是线性表位优势区域,与已知的鹅细小病毒非结构蛋白线性抗原表位区进行比较,可能具有交叉反应性的区段为AA503~509。番鸭细小病毒衣壳蛋白线性抗原表位预测结果表明：肽段AA27~33、39~50、67~75、111~115、149~155、260~264、321~325、426~430、448~452、485~489、521~525、540~544和685~691等区域可能是线性表位优势区域,与已知的鹅细小病毒衣壳蛋白线性抗原表位区进行比较,可能具有交叉反应性的区段为AA321~325、426~430、540~544和685~691。 |
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| Bibliography: | 44-1267/S In order to explain cross-reactivity between Muscovy Duck Parvovirus（MDPV） and Goose Parvovirus（GPV）,DNAMAN and DNAStar were used for the epitope analysis.It indicated that the linear epitopes on MDPV non-structural protein existed with high probability in the regions of AA248~252,503~509 and 545~554.Comparing with definite linear epitopes on GPV non-structural protein there was only one epitope might cross-react with each other,it was AA503~509.It indicated that the linear epitopes on MDPV capsid protein existed in the regions of AA27~33,39~50,67~75,111~115,149~155,260~264,321~325,426~430,448~452,485~489,521~525,540~544 and 685~691.Comparing with definite linear epitopes on GPV capsid protein there were four epitopes might cross-react with each other,they were AA321~325,426~430,540~544 and 685~691. LI Ming,YU Tian-fei,XU Shuang,SUO Li,WANG Ao,YAO Yu,YAO Yu,PENG Liang（1.College of Computer and Control Engineering,Qiqihar University,Qiqihaer 161006,China; 2.College of Life Science and Agriculture and F |
| ISSN: | 1004-874X |
| DOI: | 10.3969/j.issn.1004-874X.2011.24.040 |