Search Results - "難波宏樹"

神経幹細胞を用いた膠芽腫の遺伝子治療 by 難波宏樹

“…神経膠腫は成人原発脳腫瘍の約25％を占める腫瘍群であるが, 最も悪性の膠芽腫では診断からの生存中間値はせいぜい1年であり, ほとんどの患者は2年以内に死亡する. しかもこの成績はさまざまな治療戦略の開発にもかかわらず過去30年間ほとんど変わっていないのが現状である. 新たな治療戦略として遺伝子治療の研究が開始され,…”
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2. SPECTによるgliomaの非侵襲的抗癌剤感受性予測 by 井内俊彦, 大里克信, 戸川貴史, 油井信春, 藤本修, 難波宏樹

“…99mTc-MIBIと201T1の集積比（M/T）から, P-glycoprotein（Pgp）の発現とPgpの関与する抗癌剤耐性の予測を試みた. 対象は25例のmalignant glioma（MG）. 術前に99mTc-MIBI SPECTと201T1 SPECTを施行しM/Tを計測したうえで,…”
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15 ［11C］MP4A PETと［123I]IMP SPECTのアルツハイマー病診断能における比較検討 by 黄田常嘉, 篠遠仁, 福士清, 難波宏樹, 伊豫雅臣, 長塚伸一郎, 青墳章代, 田中典子, 棚田修二, 入江俊章

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291 塩酸ドネペジルの脳内AChE活性阻害効果の測定―標準法, 小脳reference法, shape解析法の比較 by 篠遠仁, 福士清, 長塚伸一郎, 田中典子, 青墳章代, 黄田常嘉, 難波宏樹, 棚田修二, 入江俊章

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482 痴呆性疾患における脳内コリン神経系機能 by 篠遠仁, 福士清, 長塚伸一郎, 田中典子, 青墳章代, 黄田常嘉, 難波宏樹, 棚田修二, 入江俊章

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304 11C-MP4A/PETによる脳内局所AChE活性測定：小脳をReferenceとした無採血解析法の開発 by 長塚伸一郎, 福士清, 篠遠仁, 田中典子, 難波宏樹, 青墳章代, 黄田常嘉, 棚田修二, 入江俊章

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290［11C］MP4A-PETによる塩酸ドネペジルの脳内AChE活性IC50値の測定 by 篠遠仁, 福士清, 長塚伸一郎, 田中典子, 青墳章代, 難波宏樹, 棚田修二, 入江俊章

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278 11C-MP4A／PET小脳reference法のAlzheimer病診断における有効性の評価 by 福士清, 長塚伸一朗, 篠遠仁, 田中典子, 難波宏樹, 青墳章代, 黄田常嘉, 棚田修二, 入江俊章

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307 [11C]MP4P/PETを用いた脳内AchE活性の定量測定 by 佐藤康一, 伊豫雅臣, 篠遠仁, 福士清, 田中典子, 青墳章代, 黄田常嘉, 長塚伸一郎, 難波宏樹, 棚田修二, 入江俊章

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頭部外傷後の企図振戦 by 岩立康男, 佐伯直勝, 難波宏樹, 小滝勝, 岡信男

“…重症頭部外傷生存例において, 慢性期に企図振戦をきたすことがある2, 5, 9-11, 20, 26, 30, 32, 34). 一般に, 企図振戦の責任病巣として歯状核－赤核－視床路の障害が想定されており12, 17, 28, 31), 頭部外傷後企図振戦例においても,…”
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脳挫傷における局所脳グルコース代謝率の研究 by 中村孝雄, 難波宏樹, 角南兼朗, 久保田基夫, 小沢義典, 山浦晶, 牧野博安

“…頭部外傷, とりわけ脳挫傷の病態は複雑多岐にわたり, いまだに不明な点が多い. 脳の局所に発生した脳挫傷が近接部あるいは遠位部の脳グルコース代謝, さらには脳全体のグルコース代謝に対していかに影響を及ぼすかを明らかにすることは, 二次的脳損傷発生の解明という点からも興味のあるところである. しかし,…”
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Progressive loss of cortical acetylcholinesterase activity in association with cognitive decline in Alzheimer's disease: A positron emission tomography study by Shinotoh, Hitoshi, Namba, Hiroki, Fukushi, Kiyoshi, Nagatsuka, Shin-Ichiro, Tanaka, Noriko, Aotsuka, Akiyo, Ota, Tsuneyoshi, Tanada, Shuji, Irie, Toshiaki

“…We measured brain acetylcholinesterase activity in 30 patients with Alzheimer's disease (AD) and 14 age‐matched controls by positron emission tomography (PET)…”
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Positron emission tomographic measurement of acetylcholinesterase activity reveals differential loss of ascending cholinergic systems in Parkinson's disease and progressive supranuclear palsy by Shinotoh, Hitoshi, Namba, Hiroki, Yamaguchi, Mika, Fukushi, Kiyoshi, Nagatsuka, Shin-Ichiro, Iyo, Masaomi, Asahina, Masto, Hattori, Takamichi, Tanada, Shuzi, Irie, Toshiaki

“…We measured brain acetylcholinesterase activity in 16 patients with Parkinson's disease (PD), 12 patients with progressive supranuclear palsy (PSP), and 13…”
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Kinetic Analysis of [ C]MP4A Using a High-Radioactivity Brain Region That Represents an Integrated Input Function for Measurement of Cerebral Acetylcholinesterase Activity Without Arterial Blood Sampling by Nagatsuka, Shin-Ichiro, Fukushi, Kiyoshi, Shinotoh, Hitoshi, Namba, Hiroki, Iyo, Masaomi, Tanaka, Noriko, Aotsuka, Akiyo, Ota, Tsuneyoshi, Tanada, Shuji, Irie, Toshiaki

“…N-[11C]methylpiperidin-4-yl acetate ([11C]MP4A) is an acetylcholine analog. It has been used successfully for the quantitative measurement of…”
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Human cerebral acetylcholinesterase activity measured with positron emission tomography: procedure, normal values and effect of age by Namba, H, Iyo, M, Fukushi, K, Shinotoh, H, Nagatsuka, S, Suhara, T, Sudo, Y, Suzuki, K, Irie, T

“…The regional cerebral metabolic rate of [11C]N-methyl-4-piperidyl acetate, which is nearly proportional to regional cerebral acetylcholinesterase (AChE)…”
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Brain Acetylcholinesterase Activity: Validation of a PET Tracer in a Rat Model of Alzheimer's Disease by Irie, Toshiaki, Fukushi, Kiyoshi, Namba, Hiroki, Iyo, Masaomi, Tamagami, Hiroshi, Nagatsuka, Shin-ichiro, Ikota, Nobuo

“…We developed three radioactive acetylcholine analogs--N[14C]methyl-4-piperidyl acetate ([14C]MP4A), propionate ([14C]MP4P) and isobutyrate ([14C]MP4IB)--as…”
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Positron Emission Tomographic Measurement of Brain Acetylcholinesterase Activity Using N-[11C]methylpiperidin-4-yl Acetate Without Arterial Blood Sampling: Methodology of Shape Analysis and its Diagnostic Power for Alzheimer's Disease by Tanaka, Noriko, Fukushi, Kiyoshi, Shinotoh, Hitoshi, Nagatsuka, Shin-ichiro, Namba, Hiroki, Iyo, Masaomi, Aotsuka, Akiyo, Ota, Tsuneyoshi, Tanada, Shuji, Irie, Toshiaki

“…N-[11C]methylpiperidin-4-yl acetate ([11C]MP4A) is a radiotracer that has been used successfully for the quantitative measurement of acetylcholinesterase…”
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Positron emission tomography: quantitative measurement of brain acetylcholinesterase activity using radiolabeled substrates by Namba, Hiroki, Fukushi, Kiyoshi, Nagatsuka, Shin-ichiro, Iyo, Masaomi, Shinotoh, Hitoshi, Tanada, Shuji, Irie, Toshiaki

“…A new method for quantitative measurement of brain acetylcholinesterase (AChE) activity in living human brain using positron emission tomography (PET) is…”
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In vivo measurement of acetylcholinesterase activity in the brain with a radioactive acetylcholine analog by Namba, H, Irie, T, Fukushi, K, Iyo, M

“…A novel method for visualization of brain acetylcholinesterase (AChE) in vivo has been developed. Following intravenous administration of a radiolabelled…”
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A simple method for the detection of abnormal brain regions in Alzheimer's disease patients using [11C]MP4A: comparison with [123I]IMP SPECT by Ota, Tsuneyoshi, Shinotoh, Hitoshi, Fukushi, Kiyoshi, Nagatsuka, Shin-ichiro, Namba, Hiroki, Iyo, Masaomi, Aotsuka, Akiyo, Tanaka, Noriko, Sato, Koichi, Shiraishi, Tetsuya, Tanada, Shuji, Arai, Heii, Irie, Toshiaki

“…We have developed a radiolabeled lipophilic acetylcholine analogue, N-[11C]methylpiperidin-4-yl acetate ([11C]MP4A) to measure brain acetylcholinesterase…”
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