Search Results - "细胞研究：英文版"

R＆D Systems： 引领生命科学试剂行业金标准，推进中国本土化发展

“…R＆D Systems公司作为生命科学领域重要的试剂生产商，由美国纳斯达克上市公司TECHNE全资拥有，其高品质产品获得了全球广泛认可。2013年6月，TECHNE公司的首席执行官（CEO）Charles Kummeth先生开始了对中国的访问，在R＆D…”
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Regulatory T cells in cancer immunotherapy by Tanaka, Atsushi, Sakaguchi, Shimon

“…FOXP3-expressing regulatory T （Treg） cells, which suppress aberrant immune response against self-antigens, also suppress anti-tumor immune response…”
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Plasma membrane changes during programmed cell deaths by Zhang, Yingying, Chen, Xin, Gueydan, Cyril, Han, Jiahuai

“…Ruptured and intact plasma membranes are classically considered as hallmarks of necrotic and apoptotic cell death, respectively. As such, apoptosis is usually…”
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Ubiquitin modifications by Swatek, Kirby N, Komander, David

“…Protein ubiquitination is a dynamic multifaceted post-translational modification involved in nearly all aspects of eukaryotic biology. Once attached to a…”
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Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis by Chen, Xin, He, Wan-ting, Hu, Lichen, Li, Jingxian, Fang, Yuan, Wang, Xin, Xu, Xiaozheng, Wang, Zhuo, Huang, Kai, Han, Jiahuai

“…Necroptosis and pyroptosis are two forms of programmed cell death with a common feature of plasma membrane rupture. Here we studied the morphology and…”
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Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase by Ping, Xiao-Li, Sun, Bao-Fa, Wang, Lu, Xiao, Wen, Yang, Xin, Wang, Wen-Jia, Adhikari, Samir, Shi, Yue, Lv, Ying, Chen, Yu-Sheng, Zhao, Xu, Li, Ang, Yang, Ying, Dahal, Ujwal, Lou, Xiao-Min, Liu, Xi, Huang, Jun, Yuan, Wei-Ping, Zhu, Xiao-Fan, Cheng, Tao, Zhao, Yong-Liang, Wang, Xinquan, Danielsen, Jannie M Rendtlew, Liu, Feng, Yang, Yun-Gui

“…The methyltransferase like 3 （METTL3）-containing methyltransferase complex catalyzes the N6-methyladenosine （m6A） formation, a novel epitranscriptomic marker;…”
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Double-stranded DNA in exosomes： a novel biomarker in cancer detection by Thakur, Basant Kumar, Zhang, Haiying, Becker, Annette, Matei, Irina, Huang, Yujie, Costa-Silva, Bruno, Zheng, Yan, Hoshino, Ayuko, Brazier, Helene, Xiang, Jenny, Williams, Caitlin, Rodriguez-Barrueco, Ruth, Silva, Jose M, Zhang, Weijia, Hearn, Stephen, Elemento, Olivier, Paknejad, Navid, Manova-Todorova, Katia, Welte, Karl, Bromberg, Jacqueline, Peinado, Héctor, Lyden, David

“…Exosomes, small membrane vesicles （30-100 nm） of endocytic origin secreted by most cell types, contain functional biomolecules, which can be horizontally…”
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FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis by Zhao, Xu, Yang, Ying, Sun, Bao-Fa, Shi, Yue, Yang, Xin, Xiao, Wen, Hao, Ya-Juan, Ping, Xiao-Li, Chen, Yu-Sheng, Wang, Wen-Jia, Jin, Kang-Xuan, Wang, Xing, Huang, Chun-Min, Fu, Yu, Ge, Xiao-Meng, Song, Shu-Hui, Jeong, Hyun Seok, Yanagisawa, Hiroyuki, Niu, Yamei, Jia, Gui-Fang, Wu, Wei, Tong, Wei-Min, Okamoto, Akimitsu, He, Chuan, Danielsen, Jannie M Rendtlew, Wang, Xiu-Jie, Yang, Yun-Gui

“…The role of Fat Mass and Obesity-associated protein （FTO） and its substrate N6-methyladenosine （m6A） in mRNA processing and adipogenesis remains largely…”
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Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis by Lin, Zhen, Hsu, Phillip J, Xing, Xudong, Fang, Jianhuo, Lu, Zhike, Zou, Qin, Zhang, Ke-Jia, Zhang, Xiao, Zhou, Yuchuan, Zhang, Teng, Zhang, Youcheng, Song, Wanlu, Jia, Guifang, Yang, Xuerui, He, Chuan, Tong, Ming-Han

“…Spermatogenesis is a differentiation process during which diploid spermatogonial stem cells （SSCs） produce hap- loid spermatozoa. This highly specialized…”
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Single-cell triple omics sequencing reveals genetic, epigenetic, and transcriptomic heterogeneity in hepatocellular carcinomas by Hou, Yu, Guo, Huahu, Cao, Chen, Li, Xianlong, Hu, Boqiang, Zhu, Ping, Wu, Xinglong, Wen, Lu, Tang, Fuchou, Huang, Yanyi, Peng, Jirun

“…Single-ceU genome, DNA methylome, and transcriptome sequencing methods have been separately developed. However, to accurately analyze the mechanism by which…”
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5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers by Li, Wenshuai, Zhang, Xu, Lu, Xingyu, You, Lei, Song, Yanqun, Luo, Zhongguang, Zhang, Jun, Nie, Ji, Zheng, Wanwei, Xu, Diannan, Wang, Yaping, Dong, Yuanqiang, Yu, Shulin, Hong, Jun, Shi, Jianping, Hao, Hankun, Luo, Fen, Hua, Luchun, Wang, Peng, Qian, Xiaoping, Yuan, Fang, Wei, Lianhuan, Cui, Ming, Zhang, Taiping, Liao, Quan, Dai, Menghua, Liu, Ziwen, Chen, Ge, Meckel, Katherine, Adhikari, Sarbani, Jia, Guifang, Bissonnette, Marc B, Zhang, Xinxiang, Zhao, Yupei, Zhang, Wei, He, Chuan, Liu, Jie

“…DNA modifications such as 5-methylcytosine （5mC） and 5-hydroxymethylcytosine （5hmC） are epigenetic marks known to affect global gene efpression in mammals…”
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Innate immune signaling and regulation in cancer immunotherapy by Corrales, Leticia, Matson, Vyara, Flood, Blake, Spranger, Stefani, Gajewski, Thomas F

“…A pre-existing T cell-inflamed tumor microenvironment has prognostic utility and also can be predictive for re- sponse to contemporary cancer immunotherapies…”
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Historical landmarks of autophagy research by Ohsumi, Yoshinori

“…The year of 2013 marked the 50th anniversary of C de Duve＇s coining of the term ＂autophagy＂ for the degradation process of cytoplasmic constituents in the…”
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Drugging the undruggables： exploring the ubiquitin system for drug development by Huang, Xiaodong, Dixit, Vishva M

“…Dynamic modulation of protein levels is tightly controlled in response to physiological cues. In mammalian cells, much of the protein degradation is carried…”
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Efficient genome editing in plants using a CRISPR/Cas system by Feng, Zhengyan, Zhang, Botao, Ding, Wona, Liu, Xiaodong, Yang, Dong-Lei, Wei, Pengliang, Cao, Fengqiu, Zhu, Shihua, Zhang, Feng, Mao, Yanfei, Zhu, Jian-Kang

“…Dear Editor, In the past few years, the development of sequence- specific DNA nucleases has progressed rapidly and such nucleases have shown their power in…”
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Homology-mediated end joining-based targeted integration using CRISPR/Cas9 by Yao, Xuan, Wang, Xing, Hu, Xinde, Liu, Zhen, Liu, Junlai, Zhou, Haibo, Shen, Xiaowen, Wei, Yu, Huang, Zijian, Ying, Wenqin, Wang, Yan, Nie, Yan-Hong, Zhang, Chen-Chen, Li, Sanlan, Cheng, Leping, Wang, Qifang, Wu, Yan, Huang, Pengyu, Sun, Qiang, Shi, Linyu, Yang, Hui

“…Targeted integration of transgenes can be achieved by strategies based on homologous recombination （HR）, mi- crohomology-mediated end joining （MMEJ） or…”
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Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death by Chen, Xin, Li, Wenjuan, Ren, Junming, Huang, Deli, He, Wan-ting, Song, Yunlong, Yang, Chao, Li, Wanyun, Zheng, Xinru, Chen, Pengda, Han, Jiahuai

“…Mixed lineage kinase domain-like protein （MLKL） was identified to function downstream of receptor interacting protein 3 （RIP3） in tumor necrosis factor-α…”
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Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2 by Liang, Ji, Cao, Ruixiu, Wang, Xiongjun, Zhang, Yajuan, Wang, Pan, Gao, Hong, Li, Chen, Yang, Fan, Zeng, Rong, Wei, Ping, Li, Dawei, Li, Wenfeng, Yang, Weiwei

“…Pyruvate kinase M2 isoform （PKM2） catalyzes the last step of glycolysis and plays an important role in tumor cell proliferation. Recent studies have reported…”
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Cross-kingdom inhibition of breast cancer growth by plant miR159 by Chin, Andrew R, Fong, Miranda Y, Somlo, George, Wu, Jun, Swiderski, Piotr, Wu, Xiwei, Wang, Shizhen Emily

“…MicroRNAs （miRNAs） are critical regulators of gene expression, and exert extensive impacts on development, physi- ology, and disease of eukaryotes. A high…”
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Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system by Cheng, Albert W, Wang, Haoyi, Yang, Hui, Shi, Linyu, Katz, Yarden, Theunissen, Thorold W, Rangarajan, Sudharshan, Shivalila, Chikdu S, Dadon, Daniel B, Jaenisch, Rudolf

“…Technologies allowing for specific regulation of endogenous genes are valuable for the study of gene functions and have great potential in therapeutics. We…”
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