Changes of Expression of Stretch-activated Potassium Channel TREK-1 mRNA and Protein in Hypertrophic Myocardium

The expression of stretch activated potassium channel TREK-1 mRNA and protein of hypertrophic myocardium was measured. Using a model of hypertrophy induced by coarctation of abdominal aorta in male Wistar rats, the expression of TREK-1 mRNA and protein was detected by using semi quantitative RT-PCR...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of Huazhong University of Science and Technology. Medical sciences Vol. 26; no. 1; pp. 31 - 33
Main Author:	程龙献苏方成瑞奔曾哥樊红黄恺王敏彭红玉梅春丽赵芳廖玉华
Format:	Journal Article
Language:	English
Published:	China Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022 , China 2006
Subjects:	Animals Aorta, Abdominal Constriction Hypertrophy Hypertrophy, Left Ventricular - etiology Hypertrophy, Left Ventricular - metabolism Male mRNA Myocardium - metabolism Myocardium - pathology Potassium Channels, Tandem Pore Domain - biosynthesis Potassium Channels, Tandem Pore Domain - genetics Proteins - metabolism Random Allocation Rats Rats, Wistar RNA, Messenger - biosynthesis RNA, Messenger - genetics Up-Regulation Ventricular Remodeling 心肌细胞病理机制钾元素 ventricular remodeling stretch-activated potassium channel electrical remodeling hypertrophic myocardium
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The expression of stretch activated potassium channel TREK-1 mRNA and protein of hypertrophic myocardium was measured. Using a model of hypertrophy induced by coarctation of abdominal aorta in male Wistar rats, the expression of TREK-1 mRNA and protein was detected by using semi quantitative RT-PCR and Western blot respectively. At 4th and 8th week after constriction of the abdominal aorta , rats developed significant left ventricular hypertrophy. As compared to sham-operated group, stretch-activated potassium channel TREK-1 mRNA was strongly expressed and protein was up regulated in operation groups （P〈0.05）. It was concluded that the expression of TREK-1 was up-regulated in hypertrophic myocardium induced by chronic pressure overload in Wistar rats.
Bibliography:	42-1679/R hypertrophic myocardium; stretch-activated potassium channel; ventricular remodeling;electrical remodeling hypertrophic myocardium R542.2 ventricular remodeling stretch-activated potassium channel electrical remodeling ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1672-0733 1993-1352
DOI:	10.1007/bf02828031