Changes of Regulatory T Cells in Graves＇ Disease
The immune mechanism of Graves＇ diseases （GD） and the roles of regulator T cells were investigated. In 32 patients with GD （GD group） and 20 healthy volunteers （control group）, flow cytometry was used to detect the proportion of CD4^＋CD25^＋ cells, MACS to isolate CD4^＋ CD25^＋ cells, RT-PCR to assay...
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| Published in: | Journal of Huazhong University of Science and Technology. Medical sciences Vol. 26; no. 5; pp. 545 - 547 |
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| Main Author: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
China
2006
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | The immune mechanism of Graves＇ diseases （GD） and the roles of regulator T cells were investigated. In 32 patients with GD （GD group） and 20 healthy volunteers （control group）, flow cytometry was used to detect the proportion of CD4^＋CD25^＋ cells, MACS to isolate CD4^＋ CD25^＋ cells, RT-PCR to assay the expression of FOXP3, and ELISA to test the leyel of IL-10, respectively. It was found that there was no significant change in the proportion of CD4^＋CD25^＋ T cells between GD group and control group （P〉0.05）, while secretion of IL-10 and expression of FOXP3 in GD group were lower than control group （P〈0.01 and P〈0.05, respectively）. In conclusion, though the proportion of regulatory T cells of peripheral blood lymphocytes in the patients with GD, the functions of them were significantly weakened, which might be a pathogenic factor in GD. |
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| Bibliography: | Graves＇ disease 42-1679/R FO-XP3 R442.8 Graves＇ disease; regulatory T cell; IL-10; FO-XP3 regulatory T cell IL-10 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 1672-0733 1993-1352 |
| DOI: | 10.1007/s11596-006-0515-6 |