A Facile Synthesis of Enantiomerically Pure （R）-6-Arylbinols

A Facile Synthesis of Enantiomerically Pure （R）-6-Arylbinols

This work reported a convenient method for the preparation of enantiomerically pure 6-aryl-2,2＇-dihydroxy-1, l＇- binaphthyl derivatives starting from the commercially available （R）-2,2＇-hydroxy-l, l＇-binaphthyl [（R）-I] via bromi- nation, hydrolysis and Suzuki cross coupling reaction. This novel synt...

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Bibliographic Details
Published in:中国化学：英文版 Vol. 30; no. 5; pp. 1092 - 1096
Main Author: 王文伶 龙玉华 邹志富 杨定乔
Format: Journal Article
Language:English
Published: 2012
Subjects:
NMR
交叉偶联反应
元素分析
光学纯
反应条件
合成
欧莱雅
衍生物
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Summary:This work reported a convenient method for the preparation of enantiomerically pure 6-aryl-2,2＇-dihydroxy-1, l＇- binaphthyl derivatives starting from the commercially available （R）-2,2＇-hydroxy-l, l＇-binaphthyl [（R）-I] via bromi- nation, hydrolysis and Suzuki cross coupling reaction. This novel synthetie method was characterized with high re- gioselectivity, simple operation, mild reaction conditions, and excellent yield （up to 73%）. On the other hand, we synthesized the target unknown compounds, which were confirmed by IR, 1H NMR, 13C NMR, MS and elementary analysis.
Bibliography:Wang Wenling, Long Yuhua, Zou Zhifu , Yang Dingqiao（ School of Chemistry and Environment, South China Normal University, Guangzhou, Guangdong 510006, China）
This work reported a convenient method for the preparation of enantiomerically pure 6-aryl-2,2＇-dihydroxy-1, l＇- binaphthyl derivatives starting from the commercially available （R）-2,2＇-hydroxy-l, l＇-binaphthyl [（R）-I] via bromi- nation, hydrolysis and Suzuki cross coupling reaction. This novel synthetie method was characterized with high re- gioselectivity, simple operation, mild reaction conditions, and excellent yield （up to 73%）. On the other hand, we synthesized the target unknown compounds, which were confirmed by IR, 1H NMR, 13C NMR, MS and elementary analysis.
31-1547/O6
（R）-1,1＇-bi-2-naphthols derivatives, Suzuki cross coupling reaction, chiral auxiliary, synthesis
ISSN:1001-604X
1614-7065