CONTRASTIVE STUDY OF THE TISSUE EXPRESSION AND SERUM CONCENTRATION OF PEPSINOGEN C IN GASTRIC MUCOSA DISEASES

Objective： To estimate the practical values of pepsinogen C （PGC） dynamic expression and the levels of serum pepsinogens in gastric cancer screening and diagnosis. Methods： 129 cases gastric mucosa biopsies and serum specimens were examined. The expression of PGC in stomach mucosa was detected by im...

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Published in:	Chinese journal of cancer research Vol. 18; no. 1; pp. 8 - 11
Main Author:	李红梅宁佩芳袁媛
Format:	Journal Article
Language:	English
Published:	Cancer Institute of the First Affiliated Hospital of China Medical University, Shenyang 110001 01-03-2006 Liaoning Province Cancer Hospital, Shenyang%Liaoning Province Cancer Hospital, Shenyang%Cancer Institute of the First Affiliated Hospital of China Medical University, Shenyang 110001
Subjects:	基因表达胃蛋白酶原C 胃黏膜疾病血清浓度 Pepsinogen C Serology Pepsinogen A Expression Gastric cancer
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Summary:	Objective： To estimate the practical values of pepsinogen C （PGC） dynamic expression and the levels of serum pepsinogens in gastric cancer screening and diagnosis. Methods： 129 cases gastric mucosa biopsies and serum specimens were examined. The expression of PGC in stomach mucosa was detected by immunohistochemistry. The serum concentration of pepsinogen A （sPGA） and pepsinogen C （sPGC） were determined by ELISA. Results： The positive rate of PGC antigen expression decreased in superficial gastritis （100%）, gastric ulcer or erosion （80.00%）, atrophic gastritis （34.48%） and gastric cancer （11.43%） in sequence （P〈0.05）. There was no statistics difference in concentration of sPGA and sPGC among the above 4 groups. The ratio of sPGA/sPGC decreased in superficial gastritis, gastric ulcer or erosion, atrophic gastritis and gastric cancer in sequence （P〈0.05）. There was specific correlation between the expression of PGC in stomach mucosa and the levels of sPGA/sPGC ratio in serum （rs =0.297, P=0.001）. Conclusion： Tissue expression of PGC has close relationship with different gastric diseases. The ratio of sPGA/sPGC is relative with the tissue expression of PGC antigen and may be a convenient and economic maker in screening and diagnosis of gastric cancer.
Bibliography:	Pepsinogen A R730 Expression 11-2591/R Pepsinogen C; Pepsinogen A; Expression; Serology; Gastric cancer Pepsinogen C Serology Gastric cancer
ISSN:	1000-9604 1993-0631
DOI:	10.1007/s11670-006-0008-y