Search Results - "成田, 弘和"

有糸分裂阻害薬で誘発される小核の形態とその由来 by 小前, 憲久, 成田, 弘和, 日比野, 康英, 菅野, 延彦

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(-)-(S)-10-(1-Aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic Acid(T-3761)の水溶液中及び固体状態における光分解物の構造について by 出町, 久美子, 前田, 晴世, 藤堂, 洋三, 尾島, 克二, 湖景, 哲雄, 今泉, 弘之, 田井, 賢, 中島, 良文, 成田, 弘和

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ピリドンカルボン酸系抗菌剤の研究 (第1報): 1-Aryl-6-(4-dimethylaminophenyl)-4-pyridone-3-carboxylic Acid類の合成と構造-活性相関 by 成田, 弘和, 小西, 義憲, 新田, 純, 長木, 秀嘉, 北山, 功, 渡辺, 泰雄, 才川, 勇

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ピリドンカルボン酸系抗菌剤の研究 (第2報): 1-(4-Hydroxyphenyl)-6-substituted-4-pyridone-3-carboxylic Acid類の合成と構造-活性相関 by 成田, 弘和, 小西, 義憲, 新田, 純, 小林, 順子, 渡辺, 泰雄, 南, 新三郎, 才川, 勇

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ピリドンカルボン酸系抗菌剤の研究 (第3報): 1-(4-Fluorophenyl)-and 1-(2, 4-Difluorophenyl)-6-substituted-4-pyridone-3-carboxylic Acid類の合成と構造-活性相関 by 成田, 弘和, 小西, 義憲, 新田, 純, 宮島, 三香子, 渡辺, 泰雄, 四辻, 彰, 才川, 勇

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ビリドンカルボン酸系抗菌剤及び非ステロイド性抗炎症剤の薬物相互作用 : マウスでの経口及び脳内投与による痙攣誘発 by 平井, 嗣郎, 田中, 啓一, 牧野, 伸治, 成田, 弘和

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ピリドンカルボン酸系抗菌剤の研究 (第5報): 7-Amino-6-fluoro-1-(fluorophenyl)-4-oxo-1, 8-naphthyridine-3-carboxylic Acid類の合成と構造-活性相関 by 成田, 弘和, 小西, 義憲, 新田, 純, 北山, 功, 宮島, 三香子, 渡辺, 泰雄, 四辻, 彰, 才川, 勇

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ピリドンカルボン酸系抗菌剤の研究 (第4報): 7-Amino-1-aryl-6-Huoro-4-quinoione-3-carboxylic Acid類の合成と構造-活性相関 by 成田, 弘和, 小西, 義憲, 新田, 純, 長木, 秀嘉, 小林, 順子, 渡辺, 泰雄, 南, 新三郎, 才川, 勇

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臨床検査材料から分離された肺炎球菌の経口抗菌薬に対する感受性 by 北山, 理恵子, 南, 新三郎, 堀井, 妙子, 前花, 淳子, 保田, 隆, 渡辺, 泰雄, 成田, 弘和, 出口, 浩一

“…1982年から1990年までに臨床分離されたStreptococcus pneumoniae40株の経口抗菌薬に対する感受性を測定した。その結果, benzylpcmicillin (PCG) 低感受性株は5株あり, 耐性株は認められなかった。PCG感受性株 (35株)…”
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各種β-lactam薬のβ-lactamase誘導作用の比較: Enterobacter cloacae H-27株における検討 by 茗原, 由紀, 藤巻, 一雄, 荒木, 春美, 前花, 淳子, 南, 新三郎, 保田, 隆, 渡辺, 泰雄, 成田, 弘和, 三橋, 進

“…β-lactamaseを誘導的に産生するEnterobacter cloacae H-27の培養液中に, 56種のβ-lactam薬を各々1, 10および100μg/mlになるように添加し, 2時間作用後の菌体内β-lactamase活性を測定した。その結果, methicillin, mezlocillin,…”
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Vancomycin誘発性腎毒性に対するpiperacillinの軽減作用: ウサギにおける基礎検討 by 永井, 章夫, 長沢, 峰子, 河村, 泰仁, 児玉, 卓也, 山田, 尚, 南, 新三郎, 渡辺, 泰雄, 成田, 弘和, 荻, 三男, 清水, 喜八郎

“…Vancomycin (VCM) 誘発性の腎毒性に対するpiperacillin (PIPC) の軽減作用についてウサギを用いて検討した。ウサギにVCMの300mg/kgを単回静脈内投与して腎毒性を誘発させた。PIPCはVCMとの臨床用量比を考慮して600, 300mg/kgさらに低用量の…”
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Tazobactam/Piperacillinのin vitro, in vivo抗菌活性 by 南, 新三郎, 荒木, 春美, 山田, 尚, 藤巻, 一雄, 岡本, 世紀, 北山, 理恵子, 茗原, 由紀, 松村, 尚樹, 大懸, 直子, 堀井, 妙子, 前花, 淳子, 保田, 隆, 渡辺, 泰雄, 成田, 弘和

“…Tazobactam (TAZ) のβ-lactamase阻害作用ならびにTAZとpiperacillin (PIPC) を1: 4に配合したtazobactam/piperacillin (TAZ/PIPC) のin vitro, in vivo抗菌活性について検討し, 以下の結果を得た。 1)…”
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A New Cognition-Enhancing Agent, (R)-(-)-1-(Benzo(b)thiophen-5-yl)-2-(2-(N,N-diethylamino)ethoxy)ethanol Hydrochloride. Effects on Memory Impairment in Rats Generated by Cerebral Embolization and Basal Forebrain Lesions by ONO, Satoshi, YAMAFUJI, Tetsuo, CHAKI, Hisaaki, TODO, Yozo, MAEKAWA, Mutsuko, KITAMURA, Kazunori, KIMURA, Tatsuo, NAKADA, Yasushi, MOZUMI, Kuniko, NARITA, Hirokazu

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Pyridonecarboxylic Acids as Antibacterial Agents. IX. Synthesis and Structure-Activity Relationship of 3-Substituted 10-(1-Aminocyclopropyl)-9-fluoro-7-oxo-2, 3-dihydro-7H-pyrido[1, 2, 3-de]-1, 4-benzoxazine-6-carboxylic Acids and Their 1-Thio and 1-Aza Analogues by TODO, Yozo, TAKAGI, Hiroyasu, IINO, Fumihiko, FUKUOKA, Yoshikazu, TAKAHATA, Masahiro, OKAMOTO, Seiki, SAIKAWA, Isamu, NARITA, Hirokazu

“…A series of the title compounds listed in Chart 1 have been synthesized to study the effects of 3-alkyl substituents on the antibacterial potency and in vivo…”
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Studies on Cognitive Enhancing Agents. III. Antiamnestic and Antihypoxic Activities of a Series of l-Bicycloaryl-2-(.OMEGA.-aminoalkoxy)ethanols by ONO, Satoshi, YAMAFUJI, Tetsuo, CHAKI, Hisaaki, MORITA, Hajime, TODO, Yozo, OKADA, Naomi, MAEKAWA, Mutsuko, KITAMURA, Kazunori, TAI, Masaru, NARITA, Hirokazu

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Practical Synthesis of T-3761, (S)-10-(1-Aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2, 3-dihydro-7H-pyrido[1, 2, 3-de]-1, 4-benzoxazine-6-carboxylic Acid by TODO, Yozo, TAKAGI, Hiroyasu, IINO, Fumihiko, HAYASHI, Kazuya, TAKATA, Makoto, KURODA, Hiroshi, MOMONOI, Kaishu, NARITA, Hirokazu

“…An economical 11-step synthesis of T-3761 (1), a new quinolone antibacterial agent discovered by us, has been developed. Commercially available 2, 3, 4,…”
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Studies on Cognitive Enhancing Agents. I. Antiamnestic and Antihypoxic Activities of 2-Dimethylaminoethyl Ethers and Related Compounds by ONO, Satoshi, YAMAFUJI, Tetsuo, CHAKI, Hisaaki, TODO, Yozo, MAEKAWA, Mutsuko, KITAMURA, Kazunori, TAI, Masaru, NARITA, Hirokazu

“…N-(2-Dimethylaminoethyl)carboxamide (1a-d), 2-dimethylaminoethyl alkyl ether (2a, b), and 2-dimethylaminoethyl 2-hydroxy-2-phenethyl ether (3a-c) and its amino…”
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Studies on Cognitive Enhancing Agents. II. Antiamnestic and Antihypoxic Activities of 1-Aryl-2-(2-aminoethoxy)ethanols by ONO, Satoshi, YAMAFUJI, Tetsuo, CHAKI, Hisaaki, MORITA, Hajime, TODO, Yozo, MAEKAWA, Mutsuko, KITAMURA, Kazunori, TAI, Masaru, NARITA, Hirokazu

“…A series of 2-(2-aminoethoxy)-1-phenylethanols having a variety of N- and phenyl-substitution patterns as well as 5- and 6-membered heteroaryl counterparts of…”
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Pyridonecarboxylic Acids as Antibacterial Agents. VII. Synthesis and Structure-Activity Relationship of Amino- and Hydroxyl-Substituted 7-Cycloalkyl and 7-Vinyl Derivatives of l-Cyclopropyl-6-fluoro-4- quinolone-3-carboxylic Acid by TODO, Yozo, NITTA, Jun, MIYAJIMA, Mikako, FUKUOKA, Yoshikazu, IKEDA, Yasushi, YAMASHIRO, Yoshiko, SAIKAWA, Isamu, NARITA, Hirokazu

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Pyridonecarboxylic Acids as Antibacterial Agents. VIII. Synthesis and Structure-Activity Relationship of 7-(1-Aminocyclopropyl)-4-oxo-1, 8-naphthyridine-3-carboxylic Acids and 7-(1-Aminocyclopropyl)-4-oxoquinoline-3-carboxylic Acids by TODO, Yozo, NITTA, Jun, MIYAJIMA, Mikako, FUKUOKA, Yoshikazu, YAMASHIRO, Yoshiko, NISHIDA, Nagako, SAIKAWA, Isamu, NARITA, Hirokazu

“…4-Oxo-1, 8-naphthyridine- and 4-oxoquinoline-3-carboxylic acids (2a, b and 3a-l) possessing a 1-amino-cyclopropyl group at the 7-position have been synthesized…”
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