Search Results - "山本, 雅貴"

放射光マイクロビームが可能にするタンパク質微小結晶解析 by 山本, 雅貴, 平田, 邦生, 引間, 孝明, 河野, 能顕, 上野, 剛

“…『1. はじめに』 生命の基本単位である細胞は, タンパク質, 核酸, 脂質や糖等の様々な物質で構成されている. なかでも主要な構成成分であるタンパク質は, それぞれの遺伝子情報でコードされたアミノ酸配列を持ち, それらが巧妙に折り畳まれ, 個別の立体構造をとっている. また, 個々のタンパク質の機能は,…”
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SPring-8構造生物ビームライン by 熊坂, 崇, 清水, 伸隆, 馬場, 清喜, 長谷川, 和也, 上野, 剛, 山本, 雅貴

“…『1. はじめに』 タンパク質の立体構造は, 今や生命現象の理解や応用において一般的に参照される基盤情報となっている. 近年ではそのニーズの高まりに応じて解析が盛んに行われており, 明らかとなる構造は毎年6千件を超えているが, その解析の大半はX線結晶解析によって行われたものである…”
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Crystal structure of pathogenic Staphylococcus aureus lipase complex with the anti-obesity drug orlistat by Kitadokoro, Kengo, Tanaka, Mutsumi, Hikima, Takaaki, Okuno, Yukiko, Yamamoto, Masaki, Kamitani, Shigeki

“…Staphylococcus aureus lipase (SAL), a triacylglycerol esterase, is an important virulence factor and may be a therapeutic target for infectious diseases…”
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Development of a dose‐limiting data collection strategy for serial synchrotron rotation crystallography by Hasegawa, Kazuya, Yamashita, Keitaro, Murai, Tomohiro, Nuemket, Nipawan, Hirata, Kunio, Ueno, Go, Ago, Hideo, Nakatsu, Toru, Kumasaka, Takashi, Yamamoto, Masaki

“…Serial crystallography, in which single‐shot diffraction images are collected, has great potential for protein microcrystallography. Although serial…”
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Phagocytosis is mediated by two-dimensional assemblies of the F-BAR protein GAS7 by Hanawa-Suetsugu, Kyoko, Itoh, Yuzuru, Ab Fatah, Maisarah, Nishimura, Tamako, Takemura, Kazuhiro, Takeshita, Kohei, Kubota, Satoru, Miyazaki, Naoyuki, Wan Mohamad Noor, Wan Nurul Izzati, Inaba, Takehiko, Nguyen, Nhung Thi Hong, Hamada-Nakahara, Sayaka, Oono-Yakura, Kayoko, Tachikawa, Masashi, Iwasaki, Kenji, Kohda, Daisuke, Yamamoto, Masaki, Kitao, Akio, Shimada, Atsushi, Suetsugu, Shiro

“…Phagocytosis is a cellular process for internalization of micron-sized large particles including pathogens. The Bin-Amphiphysin-Rvs167 (BAR) domain proteins,…”
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An isomorphous replacement method for efficient de novo phasing for serial femtosecond crystallography by Yamashita, Keitaro, Pan, Dongqing, Okuda, Tomohiko, Sugahara, Michihiro, Kodan, Atsushi, Yamaguchi, Tomohiro, Murai, Tomohiro, Gomi, Keiko, Kajiyama, Naoki, Mizohata, Eiichi, Suzuki, Mamoru, Nango, Eriko, Tono, Kensuke, Joti, Yasumasa, Kameshima, Takashi, Park, Jaehyun, Song, Changyong, Hatsui, Takaki, Yabashi, Makina, Iwata, So, Kato, Hiroaki, Ago, Hideo, Yamamoto, Masaki, Nakatsu, Toru

“…Serial femtosecond crystallography (SFX) with X-ray free electron lasers (XFELs) holds great potential for structure determination of challenging proteins that…”
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