Search Results - "坪井康次"

がんに対する局所的物理療法と全身的免疫療法はお互いを補完するか? by 坪井康次, Gerelchuluun Ariungerel, 善光純子, 王禹滋, 榮武二, 櫻井英幸

Get full text

Proton Beam Therapy for Large Hepatocellular Carcinoma by Sugahara, Shinji, M.D, Oshiro, Yoshiko, M.D, Nakayama, Hidetsugu, M.D, Fukuda, Kuniaki, M.D, Mizumoto, Masashi, M.D, Abei, Masato, M.D, Shoda, Junichi, M.D, Matsuzaki, Yasushi, M.D, Thono, Eriko, M.D, Tokita, Mari, B.A, Tsuboi, Koji, M.D, Tokuuye, Koichi, M.D

“…Purpose To investigate the safety and efficacy of proton beam therapy (PBT) in patients with large hepatocellular carcinoma (HCC). Methods and Materials…”
Get full text

7.心身症におけるめまい・失神 by 坪井, 康次

Get full text

L-myc癌遺伝子の増幅が認められた悪性髄膜腫の1例 by 神保猛, 坪井康次, 岩村幸雄, 金子道夫, 中川邦夫, 能勢忠男

“…髄膜腫は一般に良性の腫瘍と考えられており, 再発時にも組織学的特徴は変化しないことが多い14). しかし一方で, 経過中に臨床的に悪性像を呈し治療困難となることもまれではない11). 現在多くの悪性腫瘍で癌遺伝子の関与や遺伝子の欠損などの分子遺伝学的研究がなされているが, 明らかな相関は得られていない. 今回我々は,…”
Get full text

ラット脳腫瘍に対する腫瘍壊死因子の抗腫瘍効果 by 中川邦夫, 能勢忠男, 牧豊, 秋田靖典, 坪井康次

“…悪性脳腫瘍の治療成績向上は重要な問題の一つであり, 正常組織への障害が少なく, かつ抗腫瘍効果の強い腫瘍特異的な治療方法, 物質が期待されている. 腫瘍壊死因子(tumor necrosis factor, 以下TNF)は, 1975年, Carswell, Oldら4)によってその概念が導入されて以来,…”
Get full text

Orbital varixについて by 坪井康次, 伊藤政美, 山田隆, 能勢忠男, 牧豊

“…今回我々は, 49歳女性で, 精神分裂病に合併した右眼窩内静脈瘤の1例を経験した. 2年前より間歇性右眼球突出が見られていたが, 1982年9月に強直性痙攣発作があり, この時著明な眼球突出があった. 入院時, 仰臥位では右眼球のenophthalmosを認め, 伏臥位ではexophthalmosが認められた…”
Get full text

Venous angiomaの1手術例 by 坪井康次, 亀崎高夫, 小林栄喜, 海老原玲子, 牧豊

“…脳静脈性血管腫は, 従来まれな脳血管奇形と考えられていたが, 実際は症状を呈さないものが多いといわれる. 今回我々は, 全身痙攣を主訴とする9歳男児に, 脳派で3C, spike & wave burstを認め, CT, 脳血管造影で右頭頂葉に典型的な静脈性血管腫が明らかにされたので, これを外科的に切除した…”
Get full text

Methylmercury, an environmental electrophile capable of activation and disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y cells by Unoki, Takamitsu, Abiko, Yumi, Toyama, Takashi, Uehara, Takashi, Tsuboi, Koji, Nishida, Motohiro, Kaji, Toshiyuki, Kumagai, Yoshito

“…Methylmercury (MeHg) modifies cellular proteins via their thiol groups in a process referred to as “ S -mercuration”, potentially resulting in modulation of…”
Get full text

Proton Beam Therapy for Hepatocellular Carcinoma: The University of Tsukuba Experience by NAKAYAMA, Hidetsugu, SUGAHARA, Shinji, TOKITA, Mari, FUKUDA, Kuniaki, MIZUMOTO, Masashi, ABEI, Masato, SHODA, Junichi, SAKURAI, Hideyuki, TSUBOI, Koji, TOKUUYE, Koichi

“…The authors have published a series of studies evaluating the safety and efficacy of proton beam therapy for the treatment of hepatocellular carcinoma in a…”
Get full text

Long‐term outcomes of proton beam therapy in patients with previously untreated hepatocellular carcinoma by Fukuda, Kuniaki, Okumura, Toshiyuki, Abei, Masato, Fukumitsu, Nobuyoshi, Ishige, Kazunori, Mizumoto, Masashi, Hasegawa, Naoyuki, Numajiri, Haruko, Ohnishi, Kayoko, Ishikawa, Hitoshi, Tsuboi, Koji, Sakurai, Hideyuki, Hyodo, Ichinosuke

“…Long‐term efficacy of proton beam therapy (PBT) remains unclear for patients with previously untreated hepatocellular carcinoma (HCC). We aimed to study the…”
Get full text

後頭蓋窩腫瘍摘出後, 天幕上の腫瘍内出血をきたした転移性脳腫瘍の1例 by 松村明, 牧豊, 坪井康次, 小林栄喜, 宗像克治

“…脳腫瘍のうちで頭蓋内出血をきたすものは3～5%程度であり, 臨床症状を呈するものはさらに少ない. この中で多くはなんらの明らかな誘因もなく出血をきたすが, まれに種々の治療手段・診断手技などにより腫瘍出血が誘発される例がある. 我々は, 59才男性で天幕上下にわたる転移性脳腫瘍患者に,…”
Get full text

Assessment of PD-1 positive cells on initial and secondary resected tumor specimens of newly diagnosed glioblastoma and its implications on patient outcome by Miyazaki, Tsubasa, Ishikawa, Eiichi, Matsuda, Masahide, Akutsu, Hiroyoshi, Osuka, Satoru, Sakamoto, Noriaki, Takano, Shingo, Yamamoto, Tetsuya, Tsuboi, Koji, Matsumura, Akira

“…Glioblastoma (GBM) is the most common type of malignant brain tumor and has a very poor prognosis. Most patients relapse within 12 months despite aggressive…”
Get full text

Dose-dependent decrease in anti-oxidant capacity of whole blood after irradiation: A novel potential marker for biodosimetry by Sun, Lue, Inaba, Yohei, Sato, Keizo, Hirayama, Aki, Tsuboi, Koji, Okazaki, Ryuji, Chida, Koichi, Moritake, Takashi

“…Many reports have demonstrated that radiation stimulates reactive oxygen species (ROS) production by mitochondria for a few hours to a few days after…”
Get full text

A Prospective Study of Hypofractionated Proton Beam Therapy for Patients With Hepatocellular Carcinoma by Fukumitsu, Nobuyoshi, M.D, Sugahara, Shinji, M.D, Nakayama, Hidetsugu, M.D, Fukuda, Kuniaki, M.D, Mizumoto, Masashi, M.D, Abei, Masato, M.D, Shoda, Junichi, M.D, Thono, Eriko, M.D, Tsuboi, Koji, M.D, Tokuuye, Koichi, M.D

“…Purpose To evaluate the efficacy and safety of hypofractionated proton beam therapy for patients with hepatocellular carcinoma (HCC). Methods and Materials…”
Get full text

Histone Deacetylase Inhibitor Induced Radiation Sensitization Effects on Human Cancer Cells after Photon and Hadron Radiation Exposure by Gerelchuluun, Ariungerel, Maeda, Junko, Manabe, Eri, Brents, Colleen A, Sakae, Takeji, Fujimori, Akira, Chen, David J, Tsuboi, Koji, Kato, Takamitsu A

“…Suberoylanilide hydroxamic acid (SAHA) is a histone deacetylase inhibitor, which has been widely utilized throughout the cancer research field. SAHA-induced…”
Get full text

Metabolic analysis of radioresistant medulloblastoma stem-like clones and potential therapeutic targets by Sun, Lue, Moritake, Takashi, Ito, Kazuya, Matsumoto, Yoshitaka, Yasui, Hironobu, Nakagawa, Hidehiko, Hirayama, Aki, Inanami, Osamu, Tsuboi, Koji

“…Medulloblastoma is a fatal brain tumor in children, primarily due to the presence of treatment-resistant medulloblastoma stem cells. The energy metabolic…”
Get full text

Proton-Beam Therapy for Hepatocellular Carcinoma Associated with Portal Vein Tumor Thrombosis by Sugahara, Shinji, Nakayama, Hidetsugu, Fukuda, Kuniaki, Mizumoto, Masashi, Tokita, Mari, Abei, Masato, Shoda, Junichi, Matsuzaki, Yasushi, Thono, Eriko, Tsuboi, Koji, Tokuuye, Koichi

“…Background and Purpose: The prognosis of patients with advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) is extremely poor, as…”
Get full text

脳腫瘍例の放射線壊死に関する考察 by 吉井与志彦, 牧豊, 土佐純一, 坪井康次, 松村明, 伴野悠士, 中田義隆

“…脳腫瘍に対する放射線治療後に, CT所見から腫瘍の再発なのか, 新たな腫瘍の出現であるのか, 放射線治療に伴う放射線凝固壊死像(RN)であるのかの鑑別は常に問題となる. 我々は, 放射線治療中あるいはのちの追跡CT所見で腫瘍部付近にring状に増強効果の出現する部分を再発腫瘍として診断し,…”
Get full text

Prognostic analysis of patients who underwent gross total resection of newly diagnosed glioblastoma by Matsuda, Masahide, Kohzuki, Hidehiro, Ishikawa, Eiichi, Yamamoto, Tetsuya, Akutsu, Hiroyoshi, Takano, Shingo, Mizumoto, Masashi, Tsuboi, Koji, Matsumura, Akira

“…•Tumor involvement of the SVZ was associated with poor survival of GBM patients who underwent GTR.•Tumor involvement of the SVZ was significantly associated…”
Get full text

Dose distribution resulting from changes in aeration of nasal cavity or paranasal sinus cancer in the proton therapy by Fukumitsu, Nobuyoshi, Ishikawa, Hitoshi, Ohnishi, Kayoko, Terunuma, Toshiyuki, Mizumoto, Masashi, Numajiri, Haruko, Aihara, Teruhito, Okumura, Toshiyuki, Tsuboi, Koji, Sakae, Takeji, Sakurai, Hideyuki

“…Abstract Background and purpose Aeration in the nasal cavity and paranasal sinus (NCPS) was investigated during the course of proton therapy (PT), and the…”
Get full text