Search Results - "伊古田暢夫"

(S)-ピログルタミン酸誘導体を用いるポリヒドロキシアミン類の立体選択的合成 by 伊古田, 暢夫

“…「序論」 私は東京大学大学院時代, 故山田俊一先生の研究室(薬品製造化学)にて, 阿知波一雄先生(静岡県立大学名誉教授), 塩入孝之先生(名古屋市立大学名誉教授)のご指導の下, アミノ酸を用いた不斉反応や生理活性ペプチドの研究を行いました. 米国留学後, 故古賀憲司東京大学名誉教授の下で助手を務め,…”
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肝細胞癌症例における銅蓄積の意義 by 江原, 正明, 岡部, 真一郎, 福田, 浩之, 吉川, 正治, 税所, 宏光, 湯川, 雅枝, 伊古田, 暢夫

“…1. はじめに 生体内微量元素の過不足は各種の代謝異常や疾患を引き起こす. 特に, 生体内代謝の主要臓器である肝臓は微量金属の代謝においても主役を果たしており, 銅, 鉄の過剰を原因としたウイルソン病, ヘモクロマトーシスといった疾患が知られている1,2). また, 肝性脳症における亜鉛の関与2),…”
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1IID029 脳内AChEおよびBChE活性測定を目的としたN-[18F]fluoroethyl piperidinemethanol esterの評価 by 菊池達矢, 張明栄, 伊古田暢夫, 福士清, 荒野泰, 岡村敏充, 長嶺礼香, 鈴木和年, 入江俊章

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Planar Catechin Analogues with Alkyl Side Chains:  A Potent Antioxidant and an α-Glucosidase Inhibitor by Hakamata, Wataru, Nakanishi, Ikuo, Masuda, Yu, Shimizu, Takehiko, Higuchi, Hajime, Nakamura, Yuriko, Saito, Shinichi, Urano, Shiro, Oku, Tadatake, Ozawa, Toshihiko, Ikota, Nobuo, Miyata, Naoki, Okuda, Haruhiro, Fukuhara, Kiyoshi

“…Planar catechin analogues having various alkyl side chain lengths were synthesized, and their remarkable antioxidative abilities and α-glucosidase inhibitory…”
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Electron-transfer mechanism in radical-scavenging reactions by a vitamin E model in a protic medium by Nakanishi, Ikuo, Kawashima, Tomonori, Ohkubo, Kei, Kanazawa, Hideko, Inami, Keiko, Mochizuki, Masataka, Fukuhara, Kiyoshi, Okuda, Haruhiro, Ozawa, Toshihiko, Itoh, Shinobu, Fukuzumi, Shunichi, Ikota, Nobuo

“…The scavenging reaction of 2,2-diphenyl-1-picrylhydrazyl radical (DPPH.) or galvinoxyl radical (GO.) by a vitamin E model, 2,2,5,7,8-pentamethylchroman-6-ol…”
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Structural basis for DNA-cleaving activity of resveratrol in the presence of Cu(II) by Fukuhara, Kiyoshi, Nagakawa, Maki, Nakanishi, Ikuo, Ohkubo, Kei, Imai, Kohei, Urano, Shiro, Fukuzumi, Shunichi, Ozawa, Toshihiko, Ikota, Nobuo, Mochizuki, Masataka, Miyata, Naoki, Okuda, Haruhiro

“…Resveratrol ( 1, 3,5,4′-trihydroxy- trans-stilbene), a polyphenol found in grapes and other food products, is known as an antioxidant and cancer…”
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Effects of Metal Ions Distinguishing between One-Step Hydrogen- and Electron-Transfer Mechanisms for the Radical-Scavenging Reaction of (+)-Catechin by Nakanishi, Ikuo, Miyazaki, Kentaro, Shimada, Tomokazu, Ohkubo, Kei, Urano, Shiro, Ikota, Nobuo, Ozawa, Toshihiko, Fukuzumi, Shunichi, Fukuhara, Kiyoshi

“…A kinetic study of a hydrogen-transfer reaction from (+)-catechin (1) to galvinoxyl radical (G•) has been performed using UV−vis spectroscopy in the presence…”
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Nitration of Specific Tyrosine Residues of Cytochrome c Is Associated with Caspase-Cascade Inactivation by Nakagawa, Hidehiko, Komai, Nobuko, Takusagawa, Mitsuko, Miura, Yuri, Toda, Tosifusa, Miyata, Naoki, Ozawa, Toshihiko, Ikota, Nobuo

“…Peroxynitrite, a potent oxidative stress inducer, inhibits the mitochondrial electron transfer, induces cell death, and is considered to be involved in the…”
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Modification of nitroxyl contrast agents with multiple spins and their proton T1 relaxivity by Matsumoto, Ken-ichiro, Yakumaru, Haruko, Narazaki, Michiko, Nakagawa, Hidehiko, Anzai, Kazunori, Ikehira, Hiroo, Ikota, Nobuo

“…Abstract The purpose of this study is to test the performance of multispin nitroxyl contrast agents in improving the sensitivity of MR detection for nitroxyl…”
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Assessment of Oxidative Stress in the Spontaneously Hypertensive Rat Brain Using Electron Spin Resonance (ESR) Imaging and in Vivo L-Band ESR by LEE, Masaichi-Chang-il, SHOJI, Hirofumi, MIYAZAKI, Hiroyuki, YOSHINO, Fumihiko, HORI, Norio, TOYODA, Minoru, IKEDA, Yukio, ANZAI, Kazunori, IKOTA, Nobuo, OZAWA, Toshihiko

“…This study examined the blood brain barrier (BBB)-permeable nitroxyl compound, 3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl (MC-PROXYL), as a spin…”
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A Planar Catechin Analogue Having a More Negative Oxidation Potential than (+)-Catechin as an Electron Transfer Antioxidant against a Peroxyl Radical by Nakanishi, Ikuo, Ohkubo, Kei, Miyazaki, Kentaro, Hakamata, Wataru, Urano, Shiro, Ozawa, Toshihiko, Okuda, Haruhiro, Fukuzumi, Shunichi, Ikota, Nobuo, Fukuhara, Kiyoshi

“…The hydrogen transfer reaction of antioxidative polyphenol with reactive oxygen species has proved to be the main mechanism for radical scavenging. The planar…”
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Comparison of stable nitroxide, 3-substituted 2,2,5,5-tetramethylpyrrolidine- N-oxyls, with respect to protection from radiation, prevention of DNA damage, and distribution in mice by Anzai, Kazunori, Ueno, Megumi, Yoshida, Akira, Furuse, Masako, Aung, Winn, Nakanishi, Ikuo, Moritake, Takashi, Takeshita, Keizo, Ikota, Nobuo

“…We compared three 3-substituted 2,2,5,5-tetramethylpyrrolidine- N-oxyls (PROXYLs): carbamoyl-, methoxycarbonyl-, and hydroxymethyl-PROXYL (CM-, MC-, and…”
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Efficient radical scavenging ability of artepillin C, a major component of Brazilian propolis, and the mechanism by Nakanishi, Ikuo, Uto, Yoshihiro, Ohkubo, Kei, Miyazaki, Kentaro, Yakumaru, Haruko, Urano, Shiro, Okuda, Haruhiro, Ueda, Jun-Ichi, Ozawa, Toshihiko, Fukuhara, Kiyoshi, Fukuzumi, Shunichi, Nagasawa, Hideko, Hori, Hitoshi, Ikota, Nobuo

“…Hydrogen transfer from artepillin C to cumylperoxyl radical proceeds via one-step hydrogen atom transfer rather than via electron transfer, the rate constant…”
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N-[18F]Fluoroethylpiperidin-4ylmethyl Acetate, a Novel Lipophilic Acetylcholine Analogue for PET Measurement of Brain Acetylcholinesterase Activity by Kikuchi, Tatsuya, Zhang, Ming-Rong, Ikota, Nobuo, Fukushi, Kiyoshi, Okamura, Toshimitsu, Suzuki, Kazutoshi, Arano, Yasushi, Irie, Toshiaki

“…The reduction of acetylcholinesterase (AChE) activity in the brain has been measured in dementia disorders such as Alzheimer's disease and dementia with Lewy…”
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In Vivo Radioprotection of Mice by 3-Methyl-1-phenyl-2-pyrazolin-5-one (Edaravone; Radicut(R)), a Clinical Drug by Anzai, Kazunori, Furuse, Masako, Yoshida, Akira, Matsuyama, Azusa, Moritake, Takashi, Tsuboi, Koji, Ikota, Nobuo

“…Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one; Radicut(R)) is a brain-protecting agent used clinically to treat acute ischemic stroke with a reaction…”
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Kinetic study of the electron-transfer oxidation of the phenolate anion of a vitamin E model by molecular oxygen generating superoxide anion in an aprotic medium by Nakanishi, Ikuo, Miyazaki, Kentaro, Shimada, Tomokazu, Iizuka, Yuko, Inami, Keiko, Mochizuki, Masataka, Urano, Shiro, Okuda, Haruhiro, Ozawa, Toshihiko, Fukuzumi, Shunichi, Ikota, Nobuo, Fukuhara, Kiyoshi

“…Electron-transfer reduction of molecular oxygen (O2) by the phenolate anion (1-) of a vitamin E model, 2,2,5,7,8-pentamethylchroman-6-ol (1H), occurred to…”
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Drastic effect of several caffeic acid derivatives on the induction of heme oxygenase-1 expression revealed by quantitative real-time RT-PCR by Suzuki, Keiko, Tanaka, Izumi, Nakanishi, Ikuo, Kurematsu, Ayako, Yakumaru, Haruko, Ikota, Nobuo, Ishihara, Hiroshi

“…Among antioxidative polyphenols, caffeic acid esters such as caffeic acid phenethyl ester (CAPE) and chlorogenic acid are contained in propolis, vegetables and…”
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Heat-Treated Mineral-Yeast as a Potent Post-irradiation Radioprotector by Anzai, Kazunori, Ikota, Nobuo, Ueno, Megumi, Nyui, Minako, Kagiya, Tsutomu V

“…In vivo radioprotection of C3H mice by i.p. administration of Zn-, Mn-, Cu-, or Se-containing heattreated Saccharomyces serevisiae yeast sample was examined…”
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A Planar Catechin Analogue as a Promising Antioxidant with Reduced Prooxidant Activity by Fukuhara, Kiyoshi, Nakanishi, Ikuo, Shimada, Tomokazu, Ohkubo, Kei, Miyazaki, Kentaro, Hakamata, Wataru, Urano, Shiro, Ozawa, Toshihiko, Okuda, Haruhiro, Miyata, Naoki, Ikota, Nobuo, Fukuzumi, Shunichi

“…A planar catechin analogue (1H 2 ), in which catechol and chroman moieties in (+)-catechin are constrained to be coplanar, is an efficient radical scavenger…”
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Quantitative Measurements of Oxidative Stress in Mouse Skin Induced by X-Ray Irradiation by Chi, Cuiping, Tanaka, Ryoko, Okuda, Yohei, Ikota, Nobuo, Yamamoto, Haruhiko, Urano, Shiro, Ozawa, Toshihiko, Anzai, Kazunori

“…To find efficient methods to evaluate oxidative stress in mouse skin caused by X-ray irradiation, several markers and methodologies were examined. Hairless…”
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