Search Results - "˙Zołądek, Teresa"

Rsp5p, a New Link between the Actin Cytoskeleton and Endocytosis in the Yeast Saccharomyces cerevisiae by Kamińska, Joanna, Gajewska, Beata, Hopper, Anita K., ˙Zołądek, Teresa

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Yeast Models and Molecular Mechanisms of Neurodegenerative Diseases 2.0 by Kaminska, Joanna, Zoladek, Teresa

“…One of the goals of human genetics is to discover the variants that contribute to human diseases [...]…”
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Yeast Models and Molecular Mechanisms of Neurodegenerative Diseases by Kaminska, Joanna, Zoladek, Teresa

“…Neurodegenerative diseases are a group of age-related diseases and a growing problem in an aging society [...]…”
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The binding of the APT1 domains to phosphoinositides is regulated by metal ions in vitro by Kolakowski, Damian, Kaminska, Joanna, Zoladek, Teresa

“…Chorein is a protein of the Vps13 family, and defects in this protein cause the rare neurodegenerative disorder chorea-acanthocytosis (ChAc). Chorein is…”
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Yeast as a Model to Find New Drugs and Drug Targets for VPS13 -Dependent Neurodegenerative Diseases by Kaminska, Joanna, Soczewka, Piotr, Rzepnikowska, Weronika, Zoladek, Teresa

“…Mutations in human genes result in rare neurological diseases, including chorea-acanthocytosis. The pathogenesis of these diseases is poorly understood, and no…”
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The GTPase Arf1 Is a Determinant of Yeast Vps13 Localization to the Golgi Apparatus by Kolakowski, Damian, Rzepnikowska, Weronika, Kaniak-Golik, Aneta, Zoladek, Teresa, Kaminska, Joanna

“…VPS13 proteins are evolutionarily conserved. Mutations in the four human genes ( ) encoding VPS13A-D proteins are linked to developmental or neurodegenerative…”
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Partial Inhibition of Calcineurin Activity by Rcn2 as a Potential Remedy for Vps13 Deficiency by Wardaszka, Patrycja, Soczewka, Piotr, Sienko, Marzena, Zoladek, Teresa, Kaminska, Joanna

“…Regulation of calcineurin, a Ca /calmodulin-regulated phosphatase, is important for the nervous system, and its abnormal activity is associated with various…”
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Amino acid substitution equivalent to human chorea-acanthocytosis I2771R in yeast Vps13 protein affects its binding to phosphatidylinositol 3-phosphate by Rzepnikowska, Weronika, Flis, Krzysztof, Kaminska, Joanna, Grynberg, Marcin, Urbanek, Agnieszka, Ayscough, Kathryn R, Zoladek, Teresa

“…The rare human disorder chorea-acanthocytosis (ChAc) is caused by mutations in hVPS13A gene. The hVps13A protein interacts with actin and regulates the level…”
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Yeast and other lower eukaryotic organisms for studies of Vps13 proteins in health and disease by Rzepnikowska, Weronika, Flis, Krzysztof, Muñoz‐Braceras, Sandra, Menezes, Regina, Escalante, Ricardo, Zoladek, Teresa

“…Human Vps13 proteins are associated with several diseases, including the neurodegenerative disorder Chorea‐acanthocytosis (ChAc), yet the biology of these…”
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Targeting Copper Homeostasis Improves Functioning of vps13 Δ Yeast Mutant Cells, a Model of VPS13 -Related Diseases by Soczewka, Piotr, Tribouillard-Tanvier, Déborah, di Rago, Jean-Paul, Zoladek, Teresa, Kaminska, Joanna

“…Ion homeostasis is crucial for organism functioning, and its alterations may cause diseases. For example, copper insufficiency and overload are associated with…”
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Molecular Basis of the Pathogenic Mechanism Induced by the m.9191T>C Mutation in Mitochondrial ATP6 Gene by Su, Xin, Dautant, Alain, Godard, François, Bouhier, Marine, Zoladek, Teresa, Kucharczyk, Roza, di Rago, Jean-Paul, Tribouillard-Tanvier, Déborah

“…Probing the pathogenicity and functional consequences of mitochondrial DNA (mtDNA) mutations from patient's cells and tissues is difficult due to genetic…”
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Yeast-model-based study identified myosin- and calcium-dependent calmodulin signalling as a potential target for drug intervention in chorea-acanthocytosis by Soczewka, Piotr, Kolakowski, Damian, Smaczynska-de Rooij, Iwona, Rzepnikowska, Weronika, Ayscough, Kathryn R, Kaminska, Joanna, Zoladek, Teresa

“…Chorea-acanthocytosis (ChAc) is a rare neurodegenerative disease associated with mutations in the human gene. The mechanism of ChAc pathogenesis is unclear. A…”
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The role of Rsp5 ubiquitin ligase in regulation of diverse processes in yeast cells by Kaliszewski, Paweł, Zoładek, Teresa

“…Rsp5 is a conserved ubiquitin ligase involved in regulation of numerous cellular processes. A growing number of publications describing new functions of the…”
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Human hAtg2A protein expressed in yeast is recruited to preautophagosomal structure but does not complement autophagy defects of atg2Δ strain by Romanyuk, Daria, Polak, Anna, Maleszewska, Agnieszka, Sieńko, Marzena, Grynberg, Marcin, Żołądek, Teresa

“…Yeast Atg2, an autophagy-related protein, is highly conserved in other fungi and has two homologues in humans, one of which is hAtg2A encoded by the…”
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Mimicking the phosphorylation of Rsp5 in PKA site T761 affects its function and cellular localization by Jastrzebska, Zaneta, Kaminska, Joanna, Chelstowska, Anna, Domanska, Anna, Rzepnikowska, Weronika, Sitkiewicz, Ewa, Cholbinski, Piotr, Gourlay, Campbell, Plochocka, Danuta, Zoladek, Teresa

“…Rsp5 ubiquitin ligase belongs to the Nedd4 family of proteins, which affect a wide variety of processes in the cell. Here we document that Rsp5 shows several…”
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Yeast Rsp5 ubiquitin ligase affects the actin cytoskeleton in vivo and in vitro by Kaminska, Joanna, Spiess, Matthias, Stawiecka-Mirota, Marta, Monkaityte, Rasa, Haguenauer-Tsapis, Rosine, Urban-Grimal, Daniele, Winsor, Barbara, Zoladek, Teresa

“…Yeast Rsp5 ubiquitin ligase is involved in several cellular processes, including endocytosis. Actin patches are sites of endocytosis, a process involving actin…”
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Enhanced levels of Pis1p (phosphatidylinositol synthase) improve the growth of Saccharomyces cerevisiae cells deficient in Rsp5 ubiquitin ligase by Kaliszewski, Pawel, Ferreira, Thierry, Gajewska, Beata, Szkopinska, Anna, Berges, Thierry, Zoładek, Teresa

“…The Rsp5 ubiquitin ligase plays a role in many cellular processes including the biosynthesis of unsaturated fatty acids. The PIS1 (phosphatidylinositol…”
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Rsp5p ubiquitin ligase and the transcriptional activators Spt23p and Mga2p are involved in co-regulation of biosynthesis of end products of the mevalonate pathway and triacylglycerol in yeast Saccharomyces cerevisiae by Kaliszewski, Paweł, Szkopińska, Anna, Ferreira, Thierry, Świezewska, Ewa, Berges, Thierry, Zołądek, Teresa

“…Rsp5p, a yeast S. cerevisiae ubiquitin ligase, is essential for regulation of unsaturated fatty acid synthesis via activation of the transcriptional activators…”
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Nedd4, a human ubiquitin ligase, affects actin cytoskeleton in yeast cells by Stawiecka-Mirota, Marta, Kamińska, Joanna, Urban-Grimal, Daniele, Haines, Dale S., Żołądek, Teresa

“…Human Nedd4 ubiquitin ligase is involved in protein trafficking, signal transduction and oncogenesis. Nedd4 with an inactive WW4 domain is toxic to yeast…”
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Rsp5 ubiquitin ligase modulates translation accuracy in yeast Saccharomyces cerevisiae by Kwapisz, Marta, Cholbinski, Piotr, Hopper, Anita K, Rousset, Jean-Pierre, Zoladek, Teresa

“…Rsp5p is an essential yeast ubiquitin protein ligase that ubiquitinates multiple proteins involved in various processes. Recent studies indicate that…”
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