Search Results - "Șeremet, Oana"
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Exploring the Multifaceted Potential of Sildenafil in Medicine
Published in Medicina (Kaunas, Lithuania) (01-12-2023)“…Phosphodiesterase type 5 (PDE5) is pivotal in cellular signalling, regulating cyclic guanosine monophosphate (cGMP) levels crucial for smooth muscle relaxation…”
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PEGylated 5-aminosalicylic acid phospholipid bioconjugate: A novel prodrug designed for colon-targeted delivery
Published in Journal of drug delivery science and technology (01-11-2024)“…Inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, are chronic autoimmune disorders that significantly affect the…”
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The Influence of Sildenafil–Metformin Combination on Hyperalgesia and Biochemical Markers in Diabetic Neuropathy in Mice
Published in Medicina (Kaunas, Lithuania) (27-07-2023)“…Background and objectives: Worldwide, approximately 500 million people suffer from diabetes and at least 50% of these people develop neuropathy. Currently,…”
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Spectrophotometric versus spectrofluorometric assessment in the study of the relationships between lipid peroxidation and metabolic dysregulation
Published in Chemical biology & drug design (01-06-2019)“…Reactive oxygen species are crucial to normal cell function, but are also part of the pathogenesis of multiple modern maladies. As such, sensitive, fast, and…”
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Wound Healing and Anti-Inflammatory Effects of a Newly Developed Ointment Containing Jujube Leaves Extract
Published in Life (Basel, Switzerland) (22-11-2022)“…Mill. (jujube) is a well-known medicinal plant with pronounced wound healing properties. The present study aimed to establish the chemical composition of the…”
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Serum markers of bone fragility in type-2 diabetes mellitus
Published in Journal of Mind and Medical Sciences (01-05-2019)“…Patients with type-2 diabetes mellitus (T2DM) have normal or increased bone mineral density (BMD) but despite that, they are characterized by an increased hip…”
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Determination of pyrrolizidine alkaloids in dietary sources using a spectrophotometric method
Published in Journal of Mind and Medical Sciences (03-10-2018)“…Pyrrolizidine alkaloids (PAs) are a class of toxic compounds found in the composition of more than 6000 plants. People can be exposed to PAs by consuming…”
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Preclinical and clinical results regarding the effects of a plant-based antidiabetic formulation versus well established antidiabetic molecules
Published in Pharmacological research (01-12-2019)“…[Display omitted] Diabetes mellitus (DM) is a complex syndrome with debilitating long-term complications, comprising alterations of carbohydrate, protein and…”
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Toxicity of plant extracts containing pyrrolizidine alkaloids using alternative invertebrate models
Published in Molecular medicine reports (01-06-2018)“…Pyrrolizidine alkaloids (PAs) are a widespread class of hepatotoxic heterocyclic organic compounds found in approximately 3% of world flora. Some PAs have been…”
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Predictive power of the Triticum root elongation test for the assessment of novel anti‑proliferative therapies
Published in International journal of molecular medicine (01-07-2019)“…The use of alternative techniques to reduce the number of animals used in anticancer research is an issue of current interest. The aim of this study was to…”
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The Importance of the Pyrazole Scaffold in the Design of Protein Kinases Inhibitors as Targeted Anticancer Therapies
Published in Molecules (Basel, Switzerland) (01-07-2023)“…The altered activation or overexpression of protein kinases (PKs) is a major subject of research in oncology and their inhibition using small molecules,…”
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Effects of Venlafaxine, Risperidone and Febuxostat on Cuprizone-Induced Demyelination, Behavioral Deficits and Oxidative Stress
Published in International journal of molecular sciences (02-07-2021)“…Multiple sclerosis (MS) is a demyelinating, autoimmune disease that affects a large number of young adults. Novel therapies for MS are needed considering the…”
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THERAPEUTIC POTENTIAL OF TRAMADOL AND DEXTROMETHORPHAN ON VINCRISTINE INDUCED PERIPHERAL NEUROPATHY IN RATS
Published in Farmacia (București) (22-12-2018)Get full text
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Evaluation of Natural Extracts in Animal Models of Pain and Inflammation for a Potential Therapy of Hemorrhoidal Disease
Published in Scientia pharmaceutica (01-06-2019)“…The aim of this work was to assess the analgesic effect of three Vitis vinifera L. leaf extracts and the anti-inflammatory effect of three gels obtained from…”
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New 2-(4-(4-bromophenylsulfonyl)phenyl)-4-arylidene-oxazol-5(4H)-ones: analgesic activity and histopathological assessment
Published in Romanian journal of morphology and embryology (01-04-2020)“…This paper reports the synthesis, analgesic activity, acute toxicity and histopathological (HP) assessment of four new compounds from oxazol-5(4 H )-ones class…”
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Therapeutic potential of certain drug combinations on paclitaxel-induced peripheral neuropathy in rats
Published in Romanian journal of morphology and embryology (2017)“…Experimental research and clinical data support the potential combination therapy for the treatment of neuropathic pain. We aimed to investigate the analgesic…”
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Oral toxicity study of certain plant extracts containing pyrrolizidine alkaloids
Published in Romanian journal of morphology and embryology (2016)“…Pyrrolizidine alkaloids (PAs) are a class of toxic compounds which are found in plants. Poisoning caused by these toxins is associated with acute and chronic…”
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Influence of hyperforin on the morphology of internal organs and biochemical parameters, in experimental model in mice
Published in Romanian journal of morphology and embryology (2016)“…Hyperforin (HY) is used to treat depression and skin irritation and has been shown a number of pharmacological activities. The literature does no cite data on…”
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Pharmacotoxicological screening on new derivatives of beta-phenylethylamine, potential agonists of beta3-adrenergic receptors
Published in Romanian journal of morphology and embryology (2016)“…Beta3-adrenergic receptors (beta3-ARs) have been initially characterized in 1989. Afterwards, their tissue distribution was established: white and brown…”
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Pharmacist’s involvement in adult’s asthma management
Published in Farmacist.ro (2017)Get full text
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