Search Results - "Štěpánková, Veronika"

Cation-Specific Effects on Enzymatic Catalysis Driven by Interactions at the Tunnel Mouth by Štěpánková, Veronika, Paterová, Jana, Damborský, Jiří, Jungwirth, Pavel, Chaloupková, Radka, Heyda, Jan

“…Cationic specificity which follows the Hofmeister series has been established for the catalytic efficiency of haloalkane dehalogenase LinB by a combination of…”
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Strategies for Stabilization of Enzymes in Organic Solvents by Stepankova, Veronika, Bidmanova, Sarka, Koudelakova, Tana, Prokop, Zbynek, Chaloupkova, Radka, Damborsky, Jiri

“…One of the major barriers to the use of enzymes in industrial biotechnology is their insufficient stability under processing conditions. The use of organic…”
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Computer-aided engineering of stabilized fibroblast growth factor 21 by de La Bourdonnaye, Gabin, Ghazalova, Tereza, Fojtik, Petr, Kutalkova, Katerina, Bednar, David, Damborsky, Jiri, Rotrekl, Vladimir, Stepankova, Veronika, Chaloupkova, Radka

“…FGF21 is an endocrine signaling protein belonging to the family of fibroblast growth factors (FGFs). It has emerged as a molecule of interest for treating…”
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Structural analysis of the stable form of fibroblast growth factor 2 – FGF2-STAB by de La Bourdonnaye, Gabin, Marek, Martin, Ghazalova, Tereza, Damborsky, Jiri, Pachl, Petr, Brynda, Jiri, Stepankova, Veronika, Chaloupkova, Radka

“…[Display omitted] •Structural analysis of FGF2-STAB performed to get molecular inside into its unique properties.•Crystal structure of FGF2-STAB solved at…”
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Dynamics and hydration explain failed functional transformation in dehalogenase design by Sykora, Jan, Brezovsky, Jan, Koudelakova, Tana, Lahoda, Maryna, Fortova, Andrea, Chernovets, Tatsiana, Chaloupkova, Radka, Stepankova, Veronika, Prokop, Zbynek, Smatanova, Ivana Kuta, Hof, Martin, Damborsky, Jiri

“…The transplantation of residues from a selective to a nonselective haloalkane dehalogenase yields the correct active site geometry but not function…”
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Fibroblast Growth Factor 2 Protein Stability Provides Decreased Dependence on Heparin for Induction of FGFR Signaling and Alters ERK Signaling Dynamics by Koledova, Zuzana, Sumbal, Jakub, Rabata, Anas, de La Bourdonnaye, Gabin, Chaloupkova, Radka, Hrdlickova, Barbara, Damborsky, Jiri, Stepankova, Veronika

“…Fibroblast growth factor 2 (FGF2) plays important roles in tissue development and repair. Using heparan sulfates (HS)/heparin as a cofactor, FGF2 binds to FGF…”
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Computer-assisted stabilization of fibroblast growth factor FGF-18 by Jan Vilim, Ghazalova, Tereza, Petulova, Eliska, Horackova, Aneta, Stepankova, Veronika, Chaloupkova, Radka, Bednar, David, Damborsky, Jiri, Prokop, Zbynek

“…The fibroblast growth factors (FGF) family holds significant potential for addressing chronic diseases. Specifically, recombinant FGF18 shows promise in…”
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Enantioselectivity of Haloalkane Dehalogenases and its Modulation by Surface Loop Engineering by Prokop, Zbynek, Sato, Yukari, Brezovsky, Jan, Mozga, Tomas, Chaloupkova, Radka, Koudelakova, Tana, Jerabek, Petr, Stepankova, Veronika, Natsume, Ryo, van Leeuwen, Jan G.E, Janssen, Dick B, Florian, Jan, Nagata, Yuji, Senda, Toshiya, Damborsky, Jiri

“…In the loop: Engineering of the surface loop in haloalkane dehalogenases affects their enantiodiscrimination behavior. The temperature dependence of the…”
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DspA from Strongylocentrotus purpuratus: The first biochemically characterized haloalkane dehalogenase of non-microbial origin by Fortova, Andrea, Sebestova, Eva, Stepankova, Veronika, Koudelakova, Tana, Palkova, Lenka, Damborsky, Jiri, Chaloupkova, Radka

“…Haloalkane dehalogenases are known as bacterial enzymes cleaving a carbon–halogen bond in halogenated compounds. Here we report the first biochemically…”
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Spectrophotometric determination of octenidine in various applications forms based on hyaluronic acid by Švadlák, Daniel, Štěpánková, Veronika, Chmelař, Josef, Zápotocký, Vojtěch, Velebný, Vladimír

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The minimal inhibition concentration obtained by E-test as a criterion for selection of mutual combination of antimicrobial agents by Štěpánková, Veronika, Švadlák, Daniel, Hrudíková, Radka, Paprskářová, Alice, Zápotocký, Vojtěch, Velebný, Vladimír

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Organic co-solvents affect activity, stability and enantioselectivity of haloalkane dehalogenases by Stepankova, Veronika, Damborsky, Jiri, Chaloupkova, Radka

“…Haloalkane dehalogenases are microbial enzymes with a wide range of biotechnological applications, including biocatalysis. The use of organic co‐solvents to…”
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Exploration of Enzyme Diversity by Integrating Bioinformatics with Expression Analysis and Biochemical Characterization by Vanacek, Pavel, Sebestova, Eva, Babkova, Petra, Bidmanova, Sarka, Daniel, Lukas, Dvorak, Pavel, Stepankova, Veronika, Chaloupkova, Radka, Brezovsky, Jan, Prokop, Zbynek, Damborsky, Jiri

“…Millions of protein sequences are being discovered at an incredible pace, representing an inexhaustible source of biocatalysts. Here, we describe an integrated…”
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Different Structural Origins of the Enantioselectivity of Haloalkane Dehalogenases toward Linear β‐Haloalkanes: Open–Solvated versus Occluded–Desolvated Active Sites by Liskova, Veronika, Stepankova, Veronika, Bednar, David, Brezovsky, Jan, Prokop, Zbynek, Chaloupkova, Radka, Damborsky, Jiri

“…The enzymatic enantiodiscrimination of linear β‐haloalkanes is difficult because the simple structures of the substrates prevent directional interactions…”
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Enantioselectivity of Haloalkane Dehalogenases and its Modulation by Surface Loop Engineering by Prokop, Zbynek, Sato, Yukari, Brezovsky, Jan, Mozga, Tomas, Chaloupkova, Radka, Koudelakova, Tana, Jerabek, Petr, Stepankova, Veronika, Natsume, Ryo, van Leeuwen, Jan G. E., Janssen, Dick B., Florian, Jan, Nagata, Yuji, Senda, Toshiya, Damborsky, Jiri

“…Gezielte Mutationen der Oberflächenschleife von Halogenalkan‐Dehalogenasen haben Auswirkungen auf die Enantiodiskriminierung. Die Temperaturabhängigkeit der…”
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Computer‐assisted engineering of hyperstable fibroblast growth factor 2 by Dvorak, Pavel, Bednar, David, Vanacek, Pavel, Balek, Lukas, Eiselleova, Livia, Stepankova, Veronika, Sebestova, Eva, Kunova Bosakova, Michaela, Konecna, Zaneta, Mazurenko, Stanislav, Kunka, Antonin, Vanova, Tereza, Zoufalova, Karolina, Chaloupkova, Radka, Brezovsky, Jan, Krejci, Pavel, Prokop, Zbynek, Dvorak, Petr, Damborsky, Jiri

“…Fibroblast growth factors (FGFs) serve numerous regulatory functions in complex organisms, and their corresponding therapeutic potential is of growing interest…”
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Different Structural Origins of the Enantioselectivity of Haloalkane Dehalogenases toward Linear [beta]-Haloalkanes: Open-Solvated versus Occluded-Desolvated Active Sites by Liskova, Veronika, Stepankova, Veronika, Bednar, David, Brezovsky, Jan, Prokop, Zbynek, Chaloupkova, Radka, Damborsky, Jiri

“…The enzymatic enantiodiscrimination of linear [beta]-haloalkanes is difficult because the simple structures of the substrates prevent directional interactions…”
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Optimization of cell growth on palmitoyl‐hyaluronan knitted scaffolds developed for tissue engineering applications by Sogorkova, Jana, Zapotocky, Vojtech, Cepa, Martin, Stepankova, Veronika, Vagnerova, Hana, Batova, Jana, Pospisilova, Martina, Betak, Jiri, Nesporova, Kristina, Hermannova, Martina, Daro, Dorothée, Duffy, Garry, Velebny, Vladimir

“…Polysaccharides meet several criteria for a suitable biomaterial for tissue engineering, which include biocompatibility and ability to support the delivery and…”
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Fabrication of biodegradable textile scaffold based on hydrophobized hyaluronic acid by Zapotocky, Vojtech, Pospisilova, Martina, Janouchova, Katerina, Svadlak, Daniel, Batova, Jana, Sogorkova, Jana, Cepa, Martin, Betak, Jiri, Stepankova, Veronika, Sulakova, Romana, Kulhanek, Jaromir, Pitucha, Tomas, Vranova, Jana, Duffy, Garry, Velebny, Vladimir

“…In this work, we report on the preparation of a novel biodegradable textile scaffold made of palmitoyl-hyaluronan (palHA). Monofilament fibres of palHA with a…”
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Expansion of Access Tunnels and Active-Site Cavities Influence Activity of Haloalkane Dehalogenases in Organic Cosolvents by Stepankova, Veronika, Khabiri, Morteza, Brezovsky, Jan, Pavelka, Antonin, Sykora, Jan, Amaro, Mariana, Minofar, Babak, Prokop, Zbynek, Hof, Martin, Ettrich, Rudiger, Chaloupkova, Radka, Damborsky, Jiri

“…The use of enzymes for biocatalysis can be significantly enhanced by using organic cosolvents in the reaction mixtures. Selection of the cosolvent type and…”
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