Sodium ascorbyl phosphate in topical microemulsions

Sodium ascorbyl phosphate in topical microemulsions

Sodium ascorbyl phosphate is a hydrophilic derivative of ascorbic acid, which has improved stability arising from its chemical structure. It is used in cosmetic and pharmaceutical preparations since it has many favorable effects in the skin, the most important being antioxidant action. In order to a...

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Bibliographic Details
Published in:International journal of pharmaceutics Vol. 256; no. 1; pp. 65 - 73
Main Authors: Špiclin, Polona, Homar, Miha, Zupančič-Valant, Andreja, Gašperlin, Mirjana
Format: Journal Article Conference Proceeding
Language:English
Published: Amsterdam Elsevier B.V 30-04-2003
Elsevier
Subjects:
Administration, Topical
Ascorbic Acid - analogs & derivatives
Ascorbic Acid - chemistry
Biological and medical sciences
Diffusion
Drug Carriers - chemistry
Drug Compounding - methods
Drug Stability
Emulsions
General pharmacology
Medical sciences
Microemulsions
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Rheology
Sodium ascorbyl phosphate
Stability
Thickening agents
Topical application
Viscosity
Stability
Microemulsions
Topical application
Thickening agents
Rheology
Sodium ascorbyl phosphate
Viscosity
Thickening agent
Ascorbic acid
Pharmaceutical technology
Vitamin
In vitro
Sodium phosphate
Analog
Dosage form
Active ingredient
Microemulsion
Release
Topical administration
Rheological properties
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Description
Summary:Sodium ascorbyl phosphate is a hydrophilic derivative of ascorbic acid, which has improved stability arising from its chemical structure. It is used in cosmetic and pharmaceutical preparations since it has many favorable effects in the skin, the most important being antioxidant action. In order to achieve this, it has to be converted into free ascorbic acid by enzymatic degradation in the skin. In the present work, o/w and w/o microemulsions composed of the same ingredients, were selected as carrier systems for topical delivery of sodium ascorbyl phosphate. We showed that sodium ascorbyl phosphate was stable in both types of microemulsion with no significant influence of its location in the carrier system. To obtain liquid microemulsions appropriate for topical application, their viscosity was increased by adding thickening agents. On the basis of rheological characterization, 4.00% (m/m) colloidal silica was chosen as a suitable thickening agent for w/o microemulsions and 0.50% (m/m) xanthan gum for the o/w type. The presence of thickening agent and the location of sodium ascorbyl phosphate in the microemulsion influenced the in vitro drug release profiles. When incorporated in the internal aqueous phase, sustained release profiles were observed. This study confirmed microemulsions as suitable carrier systems for topical application of sodium ascorbyl phosphate.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0378-5173
1873-3476
DOI:10.1016/S0378-5173(03)00063-2