Search Results - "Špaček, Jiří"

Olaparib combined with chemotherapy for recurrent platinum-sensitive ovarian cancer: a randomised phase 2 trial by Oza, Amit M, Prof, Cibula, David, Prof, Benzaquen, Ana Oaknin, MD, Poole, Christopher, Prof, Mathijssen, Ron H J, Prof, Sonke, Gabe S, MD, Colombo, Nicoletta, MD, Špaček, Jiří, MD, Vuylsteke, Peter, MD, Hirte, Holger, MD, Mahner, Sven, MD, Plante, Marie, MD, Schmalfeldt, Barbara, Prof, Mackay, Helen, MD, Rowbottom, Jacqui, PhD, Lowe, Elizabeth S, MD, Dougherty, Brian, PhD, Barrett, J Carl, PhD, Friedlander, Michael, Prof

“…Summary Background The poly(ADP-ribose) polymerase inhibitor olaparib has shown antitumour activity in patients with platinum-sensitive, recurrent, high-grade…”
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Targeted DNA sequencing of high-grade serous ovarian carcinoma reveals association of TP53 mutations with platinum resistance when combined with gene expression by Holý, Petr, Hlaváč, Viktor, Šeborová, Karolína, Šůsová, Simona, Tesařová, Tereza, Rob, Lukáš, Hruda, Martin, Bouda, Jiří, Bartáková, Alena, Mrhalová, Marcela, Kopečková, Kateřina, Al Obeed Allah, Mohammad, Špaček, Jiří, Sedláková, Iva, Souček, Pavel, Václavíková, Radka

“…High-grade serous ovarian carcinoma (HGSC) is the most common subtype of ovarian cancer and is among the most fatal gynecological malignancies worldwide, due…”
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Plasmafiltration as an effective method in the removal of circulating pegylated liposomal doxorubicin (PLD) and the reduction of mucocutaneous toxicity during the treatment of advanced platinum-resistant ovarian cancer by Kubeček, Ondřej, Martínková, Jiřina, Chládek, Jaroslav, Bláha, Milan, Maláková, Jana, Hodek, Miroslav, Špaček, Jiří, Filip, Stanislav

“…Purpose The present study evaluates the safety and efficacy of double-plasma filtration (PF) to remove the exceeding pegylated liposomal doxorubicin (PLD) in…”
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Clinicopathological Characteristics and Prognostic Factors in Ovarian Metastases from Right- and Left-Sided Colorectal Cancer by Kubeček, Ondřej, Laco, Jan, Špaček, Jiří, Kubečková, Alena, Petera, Jiří, Krulichová, Iva Selke, Bezrouk, Aleš, Filip, Stanislav, Kopecký, Jindřich

“…Background: Secondary tumors of the ovary (STOs) account for 10–25% of all ovarian malignancies, including metastases from primary gynecological tumors…”
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Erratum: Filip, S.; et al. Therapeutic Apheresis, Circulating PLD, and Mucocutaneous Toxicity: Our Clinical Experience through Four Years. Pharmaceutics 2020, 12, 940 by Filip, Stanislav, Kubeček, Ondřej, Špaček, Jiří, Lánská, Miriam, Bláha, Milan

“…The following correction has been made to this paper [...]…”
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Prognostic significance of CD3+ tumor-infiltrating lymphocytes in patients with endometrial carcinoma by Čermáková, Petra, Melichar, Bohuslav, Tomšová, Markéta, Zoul, Zdeněk, Kalábová, Hana, Spaček, Jiří, Doležel, Martin

“…The aim of the present study was to investigate tumor-infiltrating leukocytes in patients with endometrial carcinoma. Cluster of differentiation (CD)3(+),…”
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Urinary Tract and Gynecologic Malignancies by Špaček, Jr, J, Petera, J, Broďák, M, Práznovec, I, Špaček, J

“…The close anatomical relationship of the urogenital system is a significant, and sometimes limiting, factor in oncogynecology. Reducing adverse effects…”
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External beam radiotherapy and high-dose brachytherapy combined with cisplatin and paclitaxel in patients with advanced cervical carcinoma by Petera, Jiří, Odrážka, Karel, Frgala, Tomáš, Špaček, Jiří

“…The aim of the present study was to evaluate toxicity and efficacy of concurrent chemoradiation with cisplatin and paclitaxel and high-dose rate (HDR)…”
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The pathogenesis, diagnosis, and management of metastatic tumors to the ovary: a comprehensive review by Kubeček, Ondřej, Laco, Jan, Špaček, Jiří, Petera, Jiří, Kopecký, Jindřich, Kubečková, Alena, Filip, Stanislav

“…Secondary tumors of the ovary account for 10–25% of all ovarian malignancies. The most common tumors that give rise to ovarian metastases include breast,…”
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Small Molecules in the Treatment of Chronic Lymphocytic Leukemia in 2015 and in the Near Future by Špaček, M

“…Chronic lymphocytic leukemia is one of the most common lymphoid malignancies and is characterized by a highly heterogeneous clinical course. Combined regimens,…”
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In memoria di Tullio De Mauro (1932–2017) by Špaček, Jiří

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DNA hypermethylation of tumor suppressor genes TWIST1, GATA4, MUS81 and NTRK1 in endometrial hyperplasia by Dvořák, Ondřej, Slavíčková, Marcela, Laco, Jan, Štěpán, Martin, Čermáková, Eva, Špaček, Jiří

“…To investigate DNA methylation of specific tumor suppressor genes in endometrial hyperplasia compared to normal endometrial tissue. File and methodology: To…”
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Ureteroarterial fistula - a severe manifestation of urological toxicity with possibly fatal consequences by Špaček, Jiří, Hoffmann, Petr, Lojík, Miroslav, Guňka, Igor, Broďák, Miloš, Petera, Jiří

“…A retrospective audit from a urological center focused on urological fistulas that directly connect with the treatment of gynecological malignancy…”
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Is there an association between pelvic organ prolapse and oxidative stress? A systematic review by Habes, Dominik, Kestranek, Jan, Stranik, Jaroslav, Kacerovsky, Marian, Spacek, Jiri

“…Introduction and hypothesis The pathophysiology of pelvic organ prolapse (POP) has not been fully elucidated, although accumulating evidence suggests that…”
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Antibiotic administration reduces the rate of intraamniotic inflammation in preterm prelabor rupture of the membranes by Kacerovsky, Marian, Romero, Roberto, Stepan, Martin, Stranik, Jaroslav, Maly, Jan, Pliskova, Lenka, Bolehovska, Radka, Palicka, Vladimir, Zemlickova, Helena, Hornychova, Helena, Spacek, Jiri, Jacobsson, Bo, Pacora, Percy, Musilova, Ivana

“…Preterm prelabor rupture of the membranes (PPROM) is frequently complicated by intraamniotic inflammatory processes such as intraamniotic infection and sterile…”
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DNA methylation of selected tumor suppressor genes in endometrial hyperplasia by Dvorak, Ondrej, Ndukwe, Munachiso, Slavickova, Marcela, Laco, Jan, Spacek, Jiri

“…Aims. To investigate DNA methylation of specific gene promoters in endometrial hyperplasia compared to normal endometrial tissue. Materials and Methods. To…”
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Non-closure of peritoneum after abdominal hysterectomy for uterine carcinoma does not increase late intestinal radiation morbidity by Sirák, Igor, Kacerovský, Marian, Hodek, Miroslav, Petera, Jiří, Špaček, Jiří, Kašaová, Linda, Zoul, Zdeněk, Vošmik, Milan

“…Abstract Background/Aim To evaluate whether non-closure of the visceral peritoneum after total abdominal hysterectomy (TAH) and bilateral salpingo-oophorectomy…”
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Clinical significance of the resistance proteins LRP, Pgp, MRP1, MRP3, and MRP5 in epithelial ovarian cancer by Sedláková, Iva, Laco, Jan, Caltová, Kateřina, Červinka, Miroslav, Tošner, Jindřich, Řezáč, Adam, Špaček, Jiří

“…This study aimed to evaluate the correlation between the expressions of lung resistance protein (LRP), P-glycoprotein (Pgp), multidrug resistance-associated…”
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High-Dose-Rate Brachytherapy as an Organ-Sparing Treatment for Early Penile Cancer by Pohanková, Denisa, Sirák, Igor, Vošmik, Milan, Kašaová, Linda, Grepl, Jakub, Paluska, Petr, Holub, Lukáš, Špaček, Jiří, Hodek, Miroslav, Kopeček, Martin, Petera, Jiří

“…Low-dose-rate brachytherapy is an effective organ-sparing treatment for patients with early-stage penile cancer. However, only limited data are available on…”
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Comparison of two long‐term gestagen regimens in the management of recurrent vulvovaginal candidiasis: A pilot study by Špaček, Jiří, Kestřánek, Jan, Jílek, Petr, Leško, Daniel, Plucnarová, Silvie, Buchta, Vladimír

“…Summary Vulvovaginal candidiasis (VVC) is a hormonal‐dependent infection but in contrast to sporadic VVC, therapy of recurrent vulvovaginal candidiasis (RVVC)…”
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