Search Results - "Šmatlíková, Petra"
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Transgenic minipig model of Huntington's disease exhibiting gradually progressing neurodegeneration
Published in Disease models & mechanisms (01-02-2020)“…Recently developed therapeutic approaches for the treatment of Huntington's disease (HD) require preclinical testing in large animal models. The minipig is a…”
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A transgenic minipig model of Huntington's disease shows early signs of behavioral and molecular pathologies
Published in Disease models & mechanisms (01-10-2018)“…Huntington's disease (HD) is a monogenic, progressive, neurodegenerative disorder with currently no available treatment. The Libechov transgenic minipig model…”
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A36 Gradual accumulation of oxidative stress and its aspects in primary porcine fibroblasts expressing mutated huntingtin
Published in Journal of neurology, neurosurgery and psychiatry (01-09-2018)“…BackgroundHuntington´s disease (HD) is devastating neurodegenerative disorder caused by the mutation in huntingtin gene. One of the largest contributors to HD…”
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Adipogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells in Pig Transgenic Model Expressing Human Mutant Huntingtin
Published in Journal of Huntington's disease (01-01-2019)“…Although the highest expression of mutant huntingtin (mtHtt) was observed in the brain, its negative effects were also apparent in other tissues. Specifically,…”
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