Search Results - "Škarydová, Lucie"

Purification and reconstitution of human membrane-bound DHRS7 (SDR34C1) from Sf9 cells by Skarka, Adam, Škarydová, Lucie, Štambergová, Hana, Wsól, Vladimír

“…•The most suitable detergent for the solubilisation of DHRS7 was determined.•DHRS7 was purified using a His10 tag on the C terminus.•DHRS7 was reconstituted…”
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Human microsomal carbonyl reducing enzymes in the metabolism of xenobiotics: well-known and promising members of the SDR superfamily by Škarydová, Lucie, Wsól, Vladimír

“…The best known, most widely studied enzyme system in phase I biotransformation is cytochrome P450 (CYP), which participates in the metabolism of roughly 9 of…”
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AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids by Škarydová, Lucie, Živná, Lucie, Xiong, Guangming, Maser, Edmund, Wsól, Vladimír

“…AKR1C3 (also known as 17β-hydroxysteroid dehydrogenase type 5 or 3α-hydroxysteroid dehydrogenase type 2) functions as a 3-keto, 17-keto and 20-ketosteroid…”
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Anthracyclines and their metabolism in human liver microsomes and the participation of the new microsomal carbonyl reductase by Skarka, Adam, Škarydová, Lucie, Štambergová, Hana, Wsól, Vladimír

“…Anthracyclines (ANTs) are widely used in the treatment of various forms of cancer. Although their usage contributes to an improvement in life expectancy, it is…”
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Deeper Insight into the Reducing Biotransformation of Bupropion in the Human Liver by Skarydova, Lucie, Tomanova, Radana, Havlikova, Lucie, Stambergova, Hana, Solich, Petr, Wsol, Vladimir

“…Bupropion is widely used as an antidepressant drug and also as a smoking cessation aid. In humans, this drug is extensively metabolized to form several…”
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Enzyme stereospecificity as a powerful tool in searching for new enzymes by Skarydová, Lucie, Skarka, Adam, Solich, Petr, Wsól, Vladimír

“…Chirality is a ubiquitous feature present in all biological systems that plays a very important role in many processes. Drug metabolism is one of these and is…”
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Efficient isolation of carbonyl-reducing enzymes using affinity approach with anticancer drug oracin as a specific ligand by SKARYDOVA, Lucie, ANDRYS, Rudolf, HOLUBOVA, Lucie, STAMBERGOVA, Hana, KNAVOVA, Jana, WSOL, Vladimir, BILKOVA, Zuzana

“…Carbonyl‐reducing enzymes are important in both metabolism of endogenous substances and biotransformation of xenobiotics. Because sufficient amounts of native…”
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Partial purification and characterization of a new human membrane-bound carbonyl reductase playing a role in the deactivation of the anticancer drug oracin by Škarydová, Lucie, Skarka, Adam, Novotná, Romana, Živná, Lucie, Martin, Hans-Jörg, Wsól, Vladimír, Maser, Edmund

“…Abstract Carbonyl reducing enzymes play important roles in the biotransformation and detoxification of endo- and xenobiotics. They are grouped into two protein…”
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Ubiquinol-10/lipids ratios in consecutive patients with different angiographic findings by Žáková, Pavla, Kand'ár, Roman, Škarydová, Lucie, Skalický, Jiří, Myjavec, Andrej, Vojtíšek, Petr

“…Information concerning un-supplemented plasma concentrations of ubiquinol-10 in coronary artery disease patients is still controversial. The aim of this study…”
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Role of carbonyl reducing enzymes in the phase I biotransformation of the non-steroidal anti-inflammatory drug nabumetone in vitro by Skarydova, Lucie, Nobilis, Milan, Wsól, Vladimir

“…1. Nabumetone is a clinically used non-steroidal anti-inflammatory drug, its biotransformation includes major active metabolite 6-methoxy-2-naphtylacetic acid…”
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Isoquinoline alkaloids as a novel type of AKR1C3 inhibitors by Skarydova, Lucie, Hofman, Jakub, Chlebek, Jakub, Havrankova, Jana, Kosanova, Katerina, Skarka, Adam, Hostalkova, Anna, Plucha, Tomas, Cahlikova, Lucie, Wsol, Vladimir

“…AKR1C3 is an important human enzyme that participates in the reduction of steroids and prostaglandins, which leads to proliferative signalling. In addition,…”
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Biochemical properties of human dehydrogenase/reductase (SDR family) member 7 by Stambergova, Hana, Skarydova, Lucie, Dunford, James E., Wsol, Vladimir

“…•We provided the basic characterization of recombinant human DHRS7 isoform 1.•DHRS7 was demonstrated to be an integral protein of endoplasmic reticulum.•The…”
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Imbalance in redox system of rat liver following permethrin treatment in adolescence and neonatal age by Gabbianelli, Rosita, Palan, Matyas, Flis, Damian Jozef, Fedeli, Donatella, Nasuti, Cinzia, Skarydova, Lucie, Ziolkowski, Wieslaw

“…Abstract 1.  The effect of different permethrin treatments on the redox system of rat liver, is presented. Two types of oral administration were chosen: (i)…”
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A simple identification of novel carbonyl reducing enzymes in the metabolism of the tobacco specific carcinogen NNK by Skarydova, Lucie, Zverinova, Michaela, Stambergova, Hana, Wsol, Vladimir

“…Tobacco smoking is the most widely known cause of human cancer-related death worldwide. NNK is one of the proved human carcinogens contributing to the…”
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Deeper Insight into the Reducing Biotransformation of Bupropion in the Human Liver by Lucie SKARYDOVA, Radana TOMANOVA, Lucie HAVLIKOVA, Hana STAMBERGOVA, Petr SOLICH, Vladimir WSOL

“…Summary：Bupropion is widely used as an antidepressant drug and also as a smoking cessation aid. In humans, this drug is extensively metabolized to form several…”
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