Search Results - "Šimek, Matěj"

Analysis of hyaluronan and its derivatives using chromatographic and mass spectrometric techniques by Šimek, Matěj, Lemr, Karel, Hermannová, Martina, Havlíček, Vladimír

“…•Hyaluronan - compound of significant interest due its roles in biology and disease.•Identification of challenges in the analysis of various hyaluronan…”
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Preparation of hyaluronan oligosaccharides by a prokaryotic beta-glucuronidase: Characterization of free and immobilized forms of the enzyme by Chatzigeorgiou, Sofia, Jílková, Jana, Korecká, Lucie, Janyšková, Radka, Hermannová, Martina, Šimek, Matej, Čožíková, Dagmar, Slováková, Marcela, Bílková, Zuzana, Bobek, Jan, Černý, Zbyněk, Čihák, Matouš, Velebný, Vladimír

“…Popularity of hyaluronan (HA) in the cosmetics and pharmaceutical industries, led to the investigation and development of new HA-based materials, with enzymes…”
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The Degradation of Hyaluronan in the Skin by Žádníková, Petra, Šínová, Romana, Pavlík, Vojtěch, Šimek, Matěj, Šafránková, Barbora, Hermannová, Martina, Nešporová, Kristina, Velebný, Vladimír

“…Hyaluronan (HA) comprises a fundamental component of the extracellular matrix and participates in a variety of biological processes. Half of the total amount…”
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LC–MS/MS study of in vivo fate of hyaluronan polymeric micelles carrying doxorubicin by Šimek, Matěj, Hermannová, Martina, Šmejkalová, Daniela, Foglová, Tereza, Souček, Karel, Binó, Lucia, Velebný, Vladimír

“…•Developed LC–MS/MS method is suitable for biodistribution study of nanocarrier.•Both the polymer matrix and the drug are estimated after one sample…”
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Enzymatically stable unsaturated hyaluronan-derived oligosaccharides with selective cytostatic properties by Klejch, Tomáš, Buffa, Radovan, Šimek, Matěj, Nešporová, Kristina, Exnerová, Andrea, Bednařík, Jiří, Brandejsová, Martina, Vágnerová, Hana, Fiala, František, Velebný, Vladimír

“…Hyaluronan, a linear glycosaminoglycan comprising D-N-acetylglucosamine and D-glucuronic acid, is the main component of the extracellular matrix. Its influence…”
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The hyaluronan metabolism in the UV-irradiated human epidermis and the relevance of in vitro epidermal models by Šínová, Romana, Pavlík, Vojtěch, Šimek, Matěj, Čepa, Martin, Ondrej, Martin, Nešporová, Kristina, Velebný, Vladimír

“…Exposure to the sun affects the skin and may eventually result in UV-induced skin damage. It is generally known that hyaluronan (HA) is one of the main…”
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Molecular weight and gut microbiota determine the bioavailability of orally administered hyaluronic acid by Šimek, Matěj, Turková, Kristýna, Schwarzer, Martin, Nešporová, Kristina, Kubala, Lukáš, Hermannová, Martina, Foglová, Tereza, Šafránková, Barbora, Šindelář, Martin, Šrůtková, Dagmar, Chatzigeorgiou, Sofia, Novotná, Tereza, Hudcovic, Tomáš, Velebný, Vladimír

“…The ability of hyaluronan as a dietary supplement to increase skin moisture and relieve knee pain has been demonstrated in several clinical studies. To…”
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Intraperitoneally administered native and lauroyl-modified hyaluronan films: Pharmacokinetic and metabolism studies by Brtková, Barbora, Hermannová, Martina, Chmelař, Josef, Nešporová, Kristina, Kocurková, Anna, Kubala, Lukáš, Ambrožová, Gabriela, Velebný, Vladimír, Šimek, Matěj

“…Hyaluronan is being investigated extensively as a biocompatible and biodegradable material for use in biomedical applications. While the derivatization of…”
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How the molecular weight affects the in vivo fate of exogenous hyaluronan delivered intravenously: A stable-isotope labelling strategy by Šimek, Matěj, Nešporová, Kristina, Kocurková, Anna, Foglová, Tereza, Ambrožová, Gabriela, Velebný, Vladimír, Kubala, Lukáš, Hermannová, Martina

“…[Display omitted] •A comprehensive pharmacokinetics of i.v. hyaluronan of five Mws (13.6−1562 kDa).•Low Mw hyaluronan is eliminated in urine, high Mw…”
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Simple area determination of strongly overlapping ion mobility peaks by Borovcová, Lucie, Hermannová, Martina, Pauk, Volodymyr, Šimek, Matěj, Havlíček, Vladimír, Lemr, Karel

“…Coupling of ion mobility with mass spectrometry has brought new frontiers in separation and quantitation of a wide range of isobaric/isomeric compounds. Ion…”
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An in vitro model that mimics the foreign body response in the peritoneum: Study of the bioadhesive properties of HA-based materials by Lehká, Kateřina, Starigazdová, Jana, Mrázek, Jiří, Nešporová, Kristina, Šimek, Matěj, Pavlík, Vojtěch, Chmelař, Josef, Čepa, Martin, Barrios-Llerena, Martin Eugenio, Kocurková, Anna, Kriváková, Eva, Koukalová, Ludmila, Kubala, Lukáš, Velebný, Vladimír

“…A cascade of reactions known as the foreign body response (FBR) follows the implantation of biomaterials leading to the formation of a fibrotic capsule around…”
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Injecting hyaluronan in the thoracolumbar fascia: A model study by Nešporová, Kristina, Matonohová, Jana, Husby, Jarmila, Toropitsyn, Evgeniy, Stupecká, Lenka Divoká, Husby, Aaron, Suchánková Kleplová, Tereza, Streďanská, Alexandra, Šimek, Matěj, Nečas, David, Vrbka, Martin, Schleip, Robert, Velebný, Vladimír

“…Hyaluronan (HA) has been recently identified as a key component of the densification of thoracolumbar fascia (TLF), a potential contributor to non-specific…”
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The effect of hydrazide linkers on hyaluronan hydrazone hydrogels by Šedová, Petra, Buffa, Radovan, Šilhár, Peter, Kovářová, Lenka, Vágnerová, Hana, Bednařík, Jiří, Basarabová, Ivana, Hejlová, Lenka, Ščigalková, Ivana, Šimek, Matěj, Velebný, Vladimír

“…[Display omitted] •Three hyaluronan derivatives (aldehyde, unsaturated aldehyde and acylated aldehyde) were crosslinked by linear or branched hydrazide to form…”
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Endogenously produced hyaluronan contributes to the regulation of peritoneal adhesion development by Kocurkova, Anna, Kerberova, Michaela, Nesporova, Kristina, Lehka, Katerina, Sandanusova, Miriam, Simek, Matej, Velebny, Vladimir, Kubala, Lukas, Ambrozova, Gabriela

“…Peritoneal adhesions are postsurgical fibrotic complications connected to peritoneal inflammation. The exact mechanism of development is unknown; however, an…”
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