Search Results - "Šimůnek, T"

Anthracycline toxicity to cardiomyocytes or cancer cells is differently affected by iron chelation with salicylaldehyde isonicotinoyl hydrazone by Šimůnek, T, Štěrba, M, Popelová, O, Kaiserová, H, Adamcová, M, Hroch, M, Hašková, P, Poňka, P, Geršl, V

“…Background and purpose: The clinical utility of anthracycline antineoplastic drugs is limited by the risk of cardiotoxicity, which has been traditionally…”
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Dexrazoxane-afforded protection against chronic anthracycline cardiotoxicity in vivo: effective rescue of cardiomyocytes from apoptotic cell death by Popelová, O, Štěrba, M, Hašková, P, Šimůnek, T, Hroch, M, Gunčová, I, Nachtigal, P, Adamcová, M, Geršl, V, Mazurová, Y

“…Background: Dexrazoxane (DEX, ICRF-187) is the only clinically approved cardioprotectant against anthracycline cardiotoxicity. It has been traditionally…”
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Iron is not involved in oxidative stress‐mediated cytotoxicity of doxorubicin and bleomycin by Kaiserová, H, Hartog, G J M, Šimůnek, T, Schröterová, L, Kvasničková, E, Bast, A

“…Background and purpose: The anticancer drugs doxorubicin and bleomycin are well‐known for their oxidative stress‐mediated side effects in heart and lung,…”
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Early detection of anthracycline cardiotoxicity in a rabbit model: left ventricle filling pattern versus troponin T determination by Sterba, M, Simůnek, T, Popelová, O, Potácová, A, Adamcová, M, Mazurová, Y, Holecková, M, Gersl, V

“…Anthracycline cardiotoxicity represents a serious risk of anticancer chemotherapy. The aim of the present pilot study was to compare the potential of both the…”
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Evaluation of ECG time intervals in a rabbit model of anthracycline-induced cardiomyopathy: a useful tool for assessment of cardioprotective agents by Potácová, A, Adamcová, M, Cajnáková, H, Hrbatová, L, Sterba, M, Popelová, O, Simůnek, T, Ponka, P, Gersl, V

“…The aim of this study was to analyze the ECG time intervals in the course of the development of chronic anthracycline cardiomyopathy in rabbits. Furthermore,…”
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Study of daunorubicin cardiotoxicity prevention with pyridoxal isonicotinoyl hydrazone in rabbits by Šimůnek, T., Klimtová, I., Kaplanová, J., Štěrba, M., Mazurová, Y., Adamcová, M., Hrdina, R., Geršl, V., Poňka, P.

“…Risk of cardiotoxicity is the most serious drawback of the clinical usefulness of anthracycline antineoplastic antibiotics, which however, remain among the…”
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Safety and tolerability of repeated administration of pyridoxal 2-chlorobenzoyl hydrazone in rabbits by Sterba, M, Simůnek, T, Mazurová, Y, Adamcová, M, Popelová, O, Kaplanova, J, Ponka, P, Gersl, V

“…Recently, pyridoxal 2-chlorobenzoyl hydrazone (o-108) has been identified as an effective iron chelator [Link et al., Blood 2003; 101: 4172-79]. Since chronic…”
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Anthracycline-induced cardiotoxicity by Hrdina, R, Gersl, V, Klimtová, I, Simůnek, T, Machácková, J, Adamcová, M

“…Anthracycline antibiotics are among the most effective and widely used antineoplastic drugs. Their usefulness is limited by a cumulative dose-related…”
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Cardiac troponin T following repeated administration of pyridoxal isonicotinoyl hydrazone in rabbits by Adamcová, M, Machácková, J, Gersl, V, Pelouch, V, Simůnek, T, Klimtová, I, Hrdina, R, Ponka, P

“…Pyridoxal isonicotinoyl hydrazone (PIH) is a new tridentate Fe-chelating agent that should be very promising in many pathological states resulting from both an…”
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Protein profiling in daunorubicin-induced cardiomyopathy by Adamcová, M, Pelouch, V, Gersl, V, Kaplanová, J, Mazurová, Y, Simůnek, T, Klimtová, I, Hrdina, R

“…The aim of this paper was to study the protein remodelling of the left ventricle following repeated administration of either daunorubicin (DNR) or DNR in…”
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The role of reactive oxygen and nitrogen species in cellular iron metabolism by Mladenka, Premysl, Simůnek, Tomás, Hübl, Mojmír, Hrdina, Radomír

“…The catalytic role of iron in the Haber-Weiss chemistry, which results in propagation of damaging reactive oxygen species (ROS), is well established. In this…”
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In vitro and in vivo examination of cardiac troponins as biochemical markers of drug-induced cardiotoxicity by ADAMCOVA, Michaela, SIMUNEK, Tomas, KAISEROVA, Helena, POPELOVA, Olga, STERBA, Martin, POTACOVA, Anna, VAVROVA, Jaroslava, MALAKOVA, Jana, GERSL, Vladimir

“…Abstract Cardiac troponin T (cTnT) and troponin I (cTnI) are becoming acknowledged as useful biochemical markers of drug-induced cardiotoxicity. In this study…”
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SIH—a novel lipophilic iron chelator—protects H9c2 cardiomyoblasts from oxidative stress-induced mitochondrial injury and cell death by Šimůnek, Tomáš, Boer, Christa, Bouwman, R. Arthur, Vlasblom, Ronald, Versteilen, Amanda M.G., Štěrba, Martin, Geršl, Vladimír, Hrdina, Radomír, Poňka, Přemysl, de Lange, Jaap J., Paulus, Walter J., Musters, René J.P.

“…Recent evidence suggests that oxidative stress is a common denominator in many aspects of cardiovascular pathogenesis. Free cellular iron plays a crucial…”
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Rabbit model for in vivo study of anthracycline-induced heart failure and for the evaluation of protective agents by Šimůnek, Tomáš, Klimtová, Ivona, Kaplanová, Jana, Mazurová, Yvona, Adamcová, Michaela, Štěrba, Martin, Hrdina, Radomír, Geršl, Vladimír

“…Background: Cardiac toxicity associated with chronic administration of anthracycline (ANT) antibiotics represents a serious complication of their use in…”
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Iron chelation-afforded cardioprotection against chronic anthracycline cardiotoxicity: A study of salicylaldehyde isonicotinoyl hydrazone (SIH) by STERBA, Martin, POPELOVA, Olga, GERSL, Vladimir, SIMUNEK, Tomas, MAZUROVA, Yvona, POTACOVA, Anna, ADAMCOVA, Michaela, GUNCOVA, Ivana, KAISEROVA, Helena, PALICKA, Vladimir, PONKA, Premysl

“…Abstract Pyridoxal-derived aroylhydrazone iron chelators have been previously shown as effective cardioprotectants against chronic anthracycline…”
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Direct administration of rutin does not protect against catecholamine cardiotoxicity by Mladěnka, Přemysl, Zatloukalová, Libuše, Šimůnek, Tomáš, Bobrovová, Zuzana, Semecký, Vladimír, Nachtigal, Petr, Hašková, Pavlína, Macková, Eliška, Vávrová, Jaroslava, Holečková, Magdaléna, Palicka, Vladimir, Hrdina, Radomír

“…Abstract High levels of catecholamines are cardiotoxic and may trigger acute myocardial infarction (AMI). Similarly, the synthetic catecholamine isoprenaline…”
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Comparison of protection by salicylaldehyde isonicotinoyl hydrazone (SIH) against hydrogen peroxide- and anthracycline-induced toxicity to cardiac cells by Simunek, Tomas, Sterba, Martin, Popelova, Olga, Kaiserova, Helena, Adamcova, Michaela, Hroch, Milos, Haskova, Pavlina, Ponka, Prem, Gersl, Vladimir

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Comparison of protective effects of two iron chelating compounds – deferiprone and dexrazoxane – against chronic anthracycline cardiotoxicity by Popelova, Olga, Sterba, Martin, Simunek, Tomas, Guncova, Ivana, Mazurová, Yvona, Hroch, Milos, Adamcova, Michaela, Gersl, Vladimir

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Proteomic analysis of the chronic anthracycline cardiotoxicity in rabbits by Sterba, Martin, Lenco, Juraj, Popelova, Olga, Fucikova, Alena, Simunek, Tomas, Mazurova, Yvona, Adamcova, Michaela, Gersl, Vladimir

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New iron chelators in anthracycline-induced cardiotoxicity by Kaiserová, Helena, Simunek, Tomás, Sterba, Martin, den Hartog, Gertjan J M, Schröterová, Ladislava, Popelová, Olga, Gersl, Vladimír, Kvasnicková, Eva, Bast, Aalt

“…The use of anthracycline anticancer drugs is limited by a cumulative, dose-dependent cardiac toxicity. Iron chelation has long been considered as a promising…”
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