Search Results - "Šimák, Ondřej"

5′-O-Methylphosphonate nucleic acids—new modified DNAs that increase the Escherichia coli RNase H cleavage rate of hybrid duplexes by Šípová, Hana, Špringer, Tomáš, Rejman, Dominik, Šimák, Ondřej, Petrová, Magdalena, Novák, Pavel, Rosenbergová, Šárka, Páv, Ondřej, Liboska, Radek, Barvík, Ivan, Štěpánek, Josef, Rosenberg, Ivan, Homola, Jiří

“…Several oligothymidylates containing various ratios of phosphodiester and isopolar 5′-hydroxyphosphonate, 5′-O-methylphosphonate and 3′-O-methylphosphonate…”
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Corrigendum to “5′-Phosphonate modified oligoadenylates as potent activators of human RNase L” [Bioorg. Med. Chem. 56 (2022) 116632] by Lášek, Tomáš, Petrová, Magdalena, Košiová, Ivana, Šimák, Ondřej, Buděšínský, Miloš, Kozák, Jaroslav, Snášel, Jan, Vavřina, Zdeněk, Birkuš, Gabriel, Rosenberg, Ivan, Páv, Ondřej

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Structures of human cytosolic and mitochondrial nucleotidases: implications for structure-based design of selective inhibitors by Pachl, Petr, Fábry, Milan, Rosenberg, Ivan, Šimák, Ondřej, Řezáčová, Pavlína, Brynda, Jiří

“…The human 5′(3′)‐deoxyribonucleotidases catalyze the dephosphorylation of deoxyribonucleoside monophosphates to the corresponding deoxyribonucleosides and thus…”
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Straightforward Synthesis of Purine 4′-Alkoxy-2′-deoxynucleosides: First Report of Mixed Purine–Pyrimidine 4′-Alkoxyoligodeoxynucleotides as New RNA Mimics by Petrová, Magdalena, Páv, Ondřej, Buděšínský, Miloš, Zborníková, Eva, Novák, Pavel, Rosenbergová, Šárka, Pačes, Ondřej, Liboska, Radek, Dvořáková, Ivana, Šimák, Ondřej, Rosenberg, Ivan

“…Purine and pyrimidine 4′-alkoxy-2′-deoxynucleosides were efficiently prepared from nucleoside 4′-5′-enol acetates in three steps by N-iodosuccinimide promoted…”
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Discovery of isonucleotidic CDNs as potent STING agonists with immunomodulatory potential by Dejmek, Milan, Šála, Michal, Brazdova, Andrea, Vanekova, Lenka, Smola, Miroslav, Klíma, Martin, Břehová, Petra, Buděšínský, Miloš, Dračínský, Martin, Procházková, Eliška, Zavřel, Martin, Šimák, Ondřej, Páv, Ondřej, Boura, Evzen, Birkuš, Gabriel, Nencka, Radim

“…Stimulator of interferon genes (STING) is an adaptor protein of the cGAS-STING signaling pathway involved in the sensing of cytosolic DNA. It functions as a…”
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Lipophosphonoxins II: Design, Synthesis, and Properties of Novel Broad Spectrum Antibacterial Agents by Seydlová, Gabriela, Pohl, Radek, Zborníková, Eva, Ehn, Marcel, Šimák, Ondřej, Panova, Natalya, Kolář, Milan, Bogdanová, Kateřina, Večeřová, Renata, Fišer, Radovan, Šanderová, Hana, Vítovská, Dragana, Sudzinová, Petra, Pospíšil, Jiří, Benada, Oldřich, Křížek, Tomáš, Sedlák, David, Bartůněk, Petr, Krásný, Libor, Rejman, Dominik

“…The increase in the number of bacterial strains resistant to known antibiotics is alarming. In this study we report the synthesis of novel compounds termed…”
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Insights into the Mechanism of Action of Bactericidal Lipophosphonoxins by Panova, Natalya, Zborníková, Eva, Šimák, Ondřej, Pohl, Radek, Kolář, Milan, Bogdanová, Kateřina, Večeřová, Renata, Seydlová, Gabriela, Fišer, Radovan, Hadravová, Romana, Šanderová, Hana, Vítovská, Dragana, Šiková, Michaela, Látal, Tomáš, Lovecká, Petra, Barvík, Ivan, Krásný, Libor, Rejman, Dominik

“…The advantages offered by established antibiotics in the treatment of infectious diseases are endangered due to the increase in the number of…”
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Structure‐Based Optimization of Bisphosphonate Nucleoside Inhibitors of Human 5′(3′)‐deoxyribonucleotidases by Pachl, Petr, Šimák, Ondřej, Buděšínský, Miloš, Brynda, Jiří, Rosenberg, Ivan, Řezáčová, Pavlína

“…Cellular 5′‐nucleotidases, enzymes regulating nucleotide/nucleoside pools, are capable of dephosphorylating phosphomonoesters of important nucleoside analogue…”
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4‑Toluenesulfonyloxymethyl‑(H)‑phosphinate: A Reagent for the Introduction of O- and S‑Methyl‑(H)‑phosphinate Moieties by Kostov, Ondřej, Páv, Ondřej, Buděšínský, Miloš, Liboska, Radek, Šimák, Ondřej, Petrová, Magdalena, Novák, Pavel, Rosenberg, Ivan

“…The straightforward synthesis of sodium 4-toluene­sulfonyl­oxymethyl-(H)-phosphinate and (H)-phosphino­methyl­isothio­uronium tosylate as new reagents for the…”
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5′-Phosphonate modified oligoadenylates as potent activators of human RNase L by Lášek, Tomáš, Petrová, Magdalena, Košiová, Ivana, Šimák, Ondřej, Buděšínský, Miloš, Kozák, Jaroslav, Snášel, Jan, Vavřina, Zdeněk, Birkuš, Gabriel, Rosenberg, Ivan, Páv, Ondřej

“…[Display omitted] The oligoadenylate synthetase-ribonuclease L pathway is a major player in the interferon-induced antiviral defense mechanism of cells. Upon…”
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Inhibition of human thymidine phosphorylase by conformationally constrained pyrimidine nucleoside phosphonic acids and their “open-structure” isosteres by Košiová, Ivana, Šimák, Ondřej, Panova, Natalya, Buděšínský, Miloš, Petrová, Magdalena, Rejman, Dominik, Liboska, Radek, Páv, Ondřej, Rosenberg, Ivan

“…A series of conformationally constrained uridine-based nucleoside phosphonic acids containing annealed 1,3-dioxolane and 1,4-dioxane rings and their…”
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Tuning the hybridization properties of modified oligonucleotides: from flexible to conformationally constrained phosphonate internucleotide linkages by Páv, Ondřej, Barvík, Ivan, Liboska, Radek, Petrová, Magdalena, Šimák, Ondřej, Rosenbergová, Šárka, Novák, Pavel, Buděšínský, Miloš, Rosenberg, Ivan

“…The concept of conformational restriction leading to the preorganization of modified strands has proven to be successful and has afforded nucleic acid…”
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Spectroscopic, Morphological, and Mechanistic Investigation of the Solvent-Promoted Aggregation of Porphyrins Modified in meso-Positions by Glucosylated Steroids by Zelenka, Karel, Trnka, Tomáš, Tišlerová, Iva, Monti, Donato, Cinti, Stefano, Naitana, Mario Luigi, Schiaffino, Luca, Venanzi, Mariano, Laguzzi, Giuseppe, Luvidi, Loredana, Mancini, Giovanna, Nováková, Zdena, Šimák, Ondřej, Wimmer, Zdeněk, Drašar, Pavel

“…Solvent‐driven aggregation of a series of porphyrin derivatives was studied by UV/Vis and circular dichroism spectroscopy. The porphyrins are characterised by…”
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A stereocontrolled synthesis of 3-acetamido-1,3,5-trideoxy- and 1,3,5,6-tetradeoxy-1,5-imino- d-glucitol by Šimák, Ondřej, Staněk, Jan, Moravcová, Jitka

“…3-Acetamido-5-amino-3,5,6-trideoxy- d-glucono-1,5-lactam and 3-acetamido-5-amino-3,5-dideoxy- d-glucono-1,5-lactam were synthesized from corresponding…”
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Asymmetrically substituted calix[4]pyrrole with chiral substituents by Štěpánek, Petr, Šimák, Ondřej, Nováková, Zdena, Wimmer, Zdeněk, Drašar, Pavel

“…We have prepared first calix[4]pyrrole containing unprotected carbohydrate moiety directly linked to meso-position of oligopyrrole by stable "C-glycosidic"…”
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Conformationally constrained nucleoside phosphonic acids--potent inhibitors of human mitochondrial and cytosolic 5'(3')-nucleotidases by Šimák, Ondřej, Pachl, Petr, Fábry, Milan, Buděšínský, Miloš, Jandušík, Tomáš, Hnízda, Aleš, Skleničková, Radka, Petrová, Magdalena, Veverka, Václav, Řezáčová, Pavlína, Brynda, Jiří, Rosenberg, Ivan

“…This work describes novel in vitro inhibitors of human mitochondrial (mdN) and cytosolic (cdN) 5'(3')-deoxynucleotidases. We designed a series of derivatives…”
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Methyl 4-toluenesulfonyloxymethylphosphonate, a new and versatile reagent for the convenient synthesis of phosphonate-containing compounds by Kóšiová, Ivana, Točík, Zdeněk, Buděšínský, Miloš, Šimák, Ondřej, Liboska, Radek, Rejman, Dominik, Pačes, Ondřej, Rosenberg, Ivan

“…A straightforward procedure leading to the new phosphonylating reagent, methyl 4-toluenesulfonyloxymethylphosphonate, requiring no chromatographic purification…”
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Oligomerization of adenosin-5′-O-ylmethylphosphonate, an isopolar AMP analogue: Evaluation of the route to short oligoadenylates by Pressová, Martina, Buděšínský, Miloš, Košiová, Ivana, Kopecký Jr, Vladimír, Cvačka, Josef, Kašička, Václav, Šimák, Ondřej, Točík, Zdeněk, Rosenberg, Ivan

“…In an attempt to prepare a library of short oligoadenylate analogues featuring both the enzyme‐stable internucleotide linkage and the 5′‐O‐methylphosphonate…”
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Insights into the Mechanism of Action of Bactericidal Lipophosphonoxins: e0145918 by Panova, Natalya, Zbornikova, Eva, Simak, Ondrej, Pohl, Radek, Kolar, Milan, Bogdanova, Katerina, Vecerova, Renata, Seydlova, Gabriela, Fiser, Radovan, Hadravova, Romana

“…The advantages offered by established antibiotics in the treatment of infectious diseases are endangered due to the increase in the number of…”
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