Antiphospholipid antibodies associated with nodal marginal zone lymphoma and its progression to diffuse large B-cell lymphoma—A case report

An association between autoimmune events, as well as the development of antiphospholipid (aPL) antibodies and lymphoproliferative disorders is well recognized. We present the patient with coagulation abnormalities and non-Hodgkin lymphoma (NHL), primarily diagnosed as nodal marginal zone B-cell lymp...

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Bibliographic Details
Published in:	Pathology, research and practice Vol. 215; no. 1; pp. 222 - 228
Main Authors:	Belančić, Andrej, Vranić, Luka, Ševeljević, Ivan, Hadžisejdić, Ita, Načinović, Antica Duletić, Jonjić, Nives
Format:	Journal Article
Language:	English
Published:	Germany Elsevier GmbH 01-01-2019
Subjects:	Anti-β2-glycoprotein I antibodies Antibodies, Antiphospholipid - immunology Antibodies, Antiphospholipid - metabolism Antiphospholipid antibody Diagnosis, Differential Disease Progression Female Humans Lupus anticoagulant Lymphoma, B-Cell, Marginal Zone - diagnosis Lymphoma, B-Cell, Marginal Zone - pathology Lymphoma, Large B-Cell, Diffuse - diagnosis Lymphoma, Large B-Cell, Diffuse - pathology Lymphoma, Non-Hodgkin - diagnosis Lymphoma, Non-Hodgkin - pathology Middle Aged Neoplasm Recurrence, Local - diagnosis Neoplasm Recurrence, Local - pathology Nodal marginal zone lymphoma Non-Hodgkin lymphoma Nodal marginal zone lymphoma Non-Hodgkin lymphoma Antiphospholipid antibody Anti-β2-glycoprotein I antibodies Lupus anticoagulant
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Summary:	An association between autoimmune events, as well as the development of antiphospholipid (aPL) antibodies and lymphoproliferative disorders is well recognized. We present the patient with coagulation abnormalities and non-Hodgkin lymphoma (NHL), primarily diagnosed as nodal marginal zone B-cell lymphoma (NMZL), and in relapse as diffuse large B-cell lymphoma (DLBCL). In the follow-up period, the patient simultaneously developed different aPL antibodies. The presence of aPL antibodies in NHL is frequent but it is not common in the NMZL. The aim of the present case report is to highlight the possible underlying increase of aPL antibodies in NMZL patients with coagulation tests abnormalities.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0344-0338 1618-0631
DOI:	10.1016/j.prp.2018.10.020