Search Results - "Šalovská, Barbora"

Beyond glucose: The crucial role of redox signaling in β-cell metabolic adaptation by Holendová, Blanka, Šalovská, Barbora, Benáková, Štěpánka, Plecitá-Hlavatá, Lydie

“…Redox signaling mediated by reversible oxidative cysteine thiol modifications is crucial for driving cellular adaptation to dynamic environmental changes,…”
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Radio-sensitizing effects of VE-821 and beyond: Distinct phosphoproteomic and metabolomic changes after ATR inhibition in irradiated MOLT-4 cells by Šalovská, Barbora, Janečková, Hana, Fabrik, Ivo, Karlíková, Radana, Čecháková, Lucie, Ondrej, Martin, Link, Marek, Friedecký, David, Tichý, Aleš

“…Current anti-cancer strategy takes advantage of tumour specific abnormalities in DNA damage response to radio- or chemo-therapy. Inhibition of the ATR/Chk1…”
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Limited Proteolysis-Coupled Mass Spectrometry Identifies Phosphatidylinositol 4,5-Bisphosphate Effectors in Human Nuclear Proteome by Sztacho, Martin, Šalovská, Barbora, Červenka, Jakub, Balaban, Can, Hoboth, Peter, Hozák, Pavel

“…Specific nuclear sub-compartments that are regions of fundamental processes such as gene expression or DNA repair, contain phosphoinositides (PIPs). PIPs thus…”
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Radiosensitization of human leukemic HL-60 cells by ATR kinase inhibitor (VE-821): phosphoproteomic analysis by Šalovská, Barbora, Fabrik, Ivo, Ďurišová, Kamila, Link, Marek, Vávrová, Jiřina, Řezáčová, Martina, Tichý, Aleš

“…DNA damaging agents such as ionizing radiation or chemotherapy are frequently used in oncology. DNA damage response (DDR)-triggered by radiation-induced double…”
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DNA-dependent protein kinase and its inhibition in support of radiotherapy by Novotná, Eva, Tichý, Aleš, Pejchal, Jaroslav, Lukášová, Emílie, Šalovská, Barbora, Vávrová, Ji ina

“…Abstract Purpose: Radiotherapy has been used as a treatment of almost 50% of all malignant tumors. The aim of this review is to provide a comprehensive…”
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Assessing the Relationship Between Mass Window Width and Retention Time Scheduling on Protein Coverage for Data-Independent Acquisition by Li, Wenxue, Chi, Hao, Salovska, Barbora, Wu, Chongde, Sun, Liangliang, Rosenberger, George, Liu, Yansheng

“…Due to the technical advances of mass spectrometers, particularly increased scanning speed and higher MS/MS resolution, the use of data-independent acquisition…”
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Radio-sensitization of human leukaemic molt-4 cells by DNA-dependent protein kinase inhibitor, NU7026 by Tichý, Ales, Novotná, Eva, Durisová, Kamila, Salovská, Barbora, Sedlaríková, Radka, Pejchal, Jaroslav, Zárybnická, Lenka, Vávrová, Jirina, Sinkorová, Zuzana, Rezácová, Martina

“…In this paper we describe the influence of NU7026, a specific inhibitor of DNA-dependent protein kinase, phosphoinositide 3-kinase, and ATM-kinase on molecular…”
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Isoform‐resolved correlation analysis between mRNA abundance regulation and protein level degradation by Salovska, Barbora, Zhu, Hongwen, Gandhi, Tejas, Frank, Max, Li, Wenxue, Rosenberger, George, Wu, Chongde, Germain, Pierre‐Luc, Zhou, Hu, Hodny, Zdenek, Reiter, Lukas, Liu, Yansheng

“…Profiling of biological relationships between different molecular layers dissects regulatory mechanisms that ultimately determine cellular function. To…”
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An optogenetic-phosphoproteomic study reveals dynamic Akt1 signaling profiles in endothelial cells by Zhou, Wenping, Li, Wenxue, Wang, Shisheng, Salovska, Barbora, Hu, Zhenyi, Tao, Bo, Di, Yi, Punyamurtula, Ujwal, Turk, Benjamin E., Sessa, William C., Liu, Yansheng

“…The serine/threonine kinase AKT is a central node in cell signaling. While aberrant AKT activation underlies the development of a variety of human diseases,…”
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Cysteine in the Spotlight: Glucose-Driven Redox Signaling in Pancreatic Beta Cells by Holendova, Blanka, Šalovská, Barbora, Benakova, Stepanka, Plecita - Hlavata, Lydie

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Peroxiredoxin 6 protects irradiated cells from oxidative stress and shapes their senescence-associated cytokine landscape by Salovska, Barbora, Kondelova, Alexandra, Pimkova, Kristyna, Liblova, Zuzana, Pribyl, Miroslav, Fabrik, Ivo, Bartek, Jiri, Vajrychova, Marie, Hodny, Zdenek

“…Cellular senescence is a complex stress response defined as an essentially irreversible cell cycle arrest mediated by the inhibition of cell cycle-specific…”
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Quantitative Proteome Profiling of Coxiella burnetii Reveals Major Metabolic and Stress Differences Under Axenic and Cell Culture Cultivation by Dresler, Jiri, Klimentova, Jana, Pajer, Petr, Salovska, Barbora, Fucikova, Alena Myslivcova, Chmel, Martin, Schmoock, Gernot, Neubauer, Heinrich, Mertens-Scholz, Katja

“…Coxiella burnetii is the causative agent of the zoonotic disease Q fever. To date, the lipopolysaccharide (LPS) is the only defined and characterized virulence…”
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Quantification of cellular protein and redox imbalance using SILAC-iodoTMT methodology by Vajrychova, Marie, Salovska, Barbora, Pimkova, Kristyna, Fabrik, Ivo, Tambor, Vojtech, Kondelova, Alexandra, Bartek, Jiri, Hodny, Zdenek

“…Under normal conditions, the cellular redox status is maintained in a steady state by reduction and oxidation processes. These redox alterations in the cell…”
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Phosphoproteomics: Searching for a needle in a haystack by Tichy, Ales, Salovska, Barbora, Rehulka, Pavel, Klimentova, Jana, Vavrova, Jirina, Stulik, Jiri, Hernychova, Lenka

“…Most of the cellular processes are regulated by reversible phosphorylation of proteins, which in turn plays a critical role in the regulation of gene…”
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Aberrantly elevated suprabasin in the bone marrow as a candidate biomarker of advanced disease state in myelodysplastic syndromes by Pribyl, Miroslav, Hubackova, Sona, Moudra, Alena, Vancurova, Marketa, Polackova, Helena, Stopka, Tomas, Jonasova, Anna, Bokorova, Radka, Fuchs, Ota, Stritesky, Jan, Salovska, Barbora, Bartek, Jiri, Hodny, Zdenek

“…Aberrantly expressed suprabasin (SBSN) is a novel biomarker in myelodysplastic syndrome (MDS) patients. The highest levels of SBSN, secreted from myeloid…”
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Phosphoproteomic analysis of metformin signaling in colorectal cancer cells elucidates mechanism of action and potential therapeutic opportunities by Salovska, Barbora, Gao, Erli, Müller‐Dott, Sophia, Li, Wenxue, Cordon, Carlos Chacon, Wang, Shisheng, Dugourd, Aurelien, Rosenberger, George, Saez‐Rodriguez, Julio, Liu, Yansheng

“…Background The biguanide drug metformin is a safe and widely prescribed drug for type 2 diabetes. Interestingly, hundreds of clinical trials have been set to…”
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Chemical inhibition of DNA repair kinases as a promising tool in oncology by Durisova, Kamila, Salovska, Barbora, Pejchal, Jaroslav, Tichy, Ales

“…DNA repair pathways play a major role in tumour resistance towards chemo- and radiotherapy. Therefore, inhibitors of specific DNA repair pathways might be…”
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Interferon‐regulated suprabasin is essential for stress‐induced stem‐like cell conversion and therapy resistance of human malignancies by Hubackova, Sona, Pribyl, Miroslav, Kyjacova, Lenka, Moudra, Alena, Dzijak, Rastislav, Salovska, Barbora, Strnad, Hynek, Tambor, Vojtech, Imrichova, Terezie, Svec, Jiri, Vodicka, Pavel, Vaclavikova, Radka, Rob, Lukas, Bartek, Jiri, Hodny, Zdenek

“…Radiation and chemotherapy represent standard‐of‐care cancer treatments. However, most patients eventually experience tumour recurrence, treatment failure and…”
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Analysis of proteomes released from in vitro cultured eight Clostridium difficile PCR ribotypes revealed specific expression in PCR ribotypes 027 and 176 confirming their genetic relatedness and clinical importance at the proteomic level by Dresler, Jiri, Krutova, Marcela, Fucikova, Alena, Klimentova, Jana, Hruzova, Veronika, Duracova, Miloslava, Houdkova, Katerina, Salovska, Barbora, Matejkova, Jana, Hubalek, Martin, Pajer, Petr, Pisa, Libor, Nyc, Otakar

“…is the causative agent of . infection (CDI) that could be manifested by diarrhea, pseudomembranous colitis or life-threatening toxic megacolon. The spread of…”
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Post‐translational modification and phenotype by Salovska, Barbora, Liu, Yansheng

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