Search Results - "ŠÍROVÁ, M."

HPMA copolymer-based polymer conjugates for the delivery and controlled release of retinoids by Lidický, O, Šírová, M, Etrych, T

“…In this paper, we describe the synthesis, physicochemical characterization, drug release kinetics and preliminary biological evaluation of several…”
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New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting by Chytil, P., Etrych, T., Koňák, Č., Šírová, M., Mrkvan, T., Bouček, J., Říhová, B., Ulbrich, K.

“…Various conjugates of anticancer drug doxorubicin (Dox) covalently bound by the hydrolytically degradable hydrazone bond to the drug carrier based on…”
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The comparison of in vivo properties of water-soluble HPMA-based polymer conjugates with doxorubicin prepared by controlled RAFT or free radical polymerization by Chytil, P, Šírová, M, Koziolová, E, Ulbrich, K, Říhová, B, Etrych, T

“…Two conjugates of anticancer drug doxorubicin (Dox) covalently bound by the hydrolytically degradable hydrazone bond to the polymer carrier based on…”
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Polymer nitric oxide donors potentiate the treatment of experimental solid tumours by increasing drug accumulation in the tumour tissue by Studenovsky, M., Sivak, L., Sedlacek, O., Konefal, R., Horkova, V., Etrych, T., Kovar, M., Rihova, B., Sirova, M.

“…The delivery of nitric oxide (NO) specifically to solid tumours was explored in this study as a strategy to augment the passive accumulation of nanomedicines…”
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Influence of the Bcg Locus on Natural Resistance to Primary Infection with the Facultative Intracellular Bacterium Francisella tularensis in Mice by KOVAROVA, H, HERNYCHOVA, L, HAJDUCH, M, SIROVA, M, MACELA, A

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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HPMA copolymer-bound doxorubicin induces immunogenic tumor cell death by Sirova, M, Kabesova, M, Kovar, L, Etrych, T, Strohalm, J, Ulbrich, K, Rihova, B

“…Treatment of murine EL4 T cell lymphoma with N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer conjugates of doxorubicin (Dox) leads to complete tumor…”
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Surface Modification of Polyimide Sheets for Regenerative Medicine Applications by Van Vlierberghe, S, Sirova, M, Rossmann, P, Thielecke, H, Boterberg, V, Rihova, B, Schacht, E, Dubruel, P

“…In the present work, two strategies were elaborated to surface-functionalize implantable polyimide sheets. In the first methodology, cross-linkable vinyl…”
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Synergistic Action of Doxorubicin Bound to the Polymeric Carrier Based on N-(2-Hydroxypropyl)methacrylamide Copolymers through an Amide or Hydrazone Bond by Říhová, B, Etrych, T, Šírová, M, Kovář, L, Hovorka, O, Kovář, M, Benda, A, Ulbrich, K

“…The cytostatic effects of polymeric conjugates based on N-(2-hydroxypropyl)methacrylamide copolymers (PHPMA) and containing doxorubicin bound through amide and…”
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Effect of aging on the expression of intracellular Ca²⁺ transport proteins in a rat heart by Kaplan, P, Jurkovicova, D, Babusikova, E, Hudecova, S, Racay, P, Sirova, M, Lehotsky, J, Drgova, A, Dobrota, D, Krizanova, O

“…Aging process is accompanied by various biological dysfunctions including altered calcium homeostasis. Modified calcium handling might be responsible for…”
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Cytotoxic and cytostatic effects of anti-Thy 1.2 targeted doxorubicin and cyclosporin A by Říhová, B., Strohalm, J., Plocová, D., Šubr, V., Šrogl, J., Jelínková, M., Šírová, M., Ulbrich, K.

“…Recently we have developed a new generation of antibody-targeted immunosuppressive (cyclosporin A, CyA) and cytostatic (doxorubicin, Dox) drugs effective in…”
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Limited T helper cell activity in C57BL/10 (B10) mice with inherited low IgG responsiveness by Sírová, M, Ríha, I, Ríhová, B

“…Due to limitations in antigen processing, mice of the C57BL/10ScSn (B10) strain exhibit a low IgG production against a variety of T-dependent antigens. To…”
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Effect of aging on the expression of intracellular Ca(2+) transport proteins in a rat heart by Kaplan, P, Jurkovicova, D, Babusikova, E, Hudecova, S, Racay, P, Sirova, M, Lehotsky, J, Drgova, A, Dobrota, D, Krizanova, O

“…Aging process is accompanied by various biological dysfunctions including altered calcium homeostasis. Modified calcium handling might be responsible for…”
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Acquired and specific immunological mechanisms co-responsible for efficacy of polymer-bound drugs by Řı́hová, B, Strohalm, J, Kubáčková, K, Jelı́nková, M, Hovorka, O, Kovář, M, Plocová, D, Šı́rová, M, Št’astný, M, Rozprimová, L, Ulbrich, K

“…We present data providing new evidence that poly[ N-(2-hydroxypropyl)methacrylamide] (PHPMA)-bound drugs, unlike free drugs, have both cytostatic and…”
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The in vivo antibody response against exogenous antigens is not influenced by the mouse Bcg (Nramp1) gene by ŠÍROVÁ, M., HOVORKA, O., ŘÍHA, I., ŘÍHOVÁ, B., BAUDYŠ, M., KIM, S.‐W., SKAMENE, E.

“…The mouse Nramp1 (Bcg) gene on chromosome 1 exerts pleiotropic effects on macrophage function. The gene is known to affect presentation of mycobacteria, and…”
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Induction of Systemic Antitumour Resistance with Targeted Polymers by Rihova, B., Strohalm, J., Kovar, M., Mrkvan, T., Subr, V., Hovorka, O., Sirova, M., Rozprimova, L., Kubackova, K., Ulbrich, K.

“…Conjugates based on N‐(2‐hydroxypropyl)methacrylamide (HPMA) represent a new generation of antibody‐targeted polymeric anticancer drugs with both cytotoxic and…”
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HPMA copolymer conjugates for dual therapy by Etrych, T., Krakovičová, H., Šírová, M., Říhová, B., Ulbrich, K.

“…The synthesis and physico-chemical and biological properties of new HPMA-based polymer conjugates intended for combination cancer chemotherapy are described…”
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Uranyl acetate modulates gene expression and protein levels of the type 2, but not type 1 inositol 1,4,5-trisphosphate receptors in mouse kidney by Ondrias, K, Sirova, M, Kubovcakova, L, Krizanova, O

“…Nephrotoxic effect of uranium is already well documented. Nevertheless, little is known about the effect of uranium on calcium homeostasis and calcium…”
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Immunoprotective therapy with targeted anticancer drugs by Říhová, B., Strohalm, J., Hoste, K., Jelínková, M., Hovorka, O., Kovář, M., Plocová, D., Šírová, M., Št'astný, M., Schacht, E., Ulbrich, K.

“…Doxorubicin or mitomycin C bonded to poly[N5‐(2‐hydroxyethyl)‐L‐glutamine]‐graft‐poly(ethylene glycol) or poly[N‐(2‐hydroxypropyl)methacrylamide], non‐targeted…”
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Natural resistance to intracellular parasites: a study by two-dimensional gel electrophoresis coupled with multivariate analysis by Kovárová, H, Radzioch, D, Hajdúch, M, Sirová, M, Bláha, V, Macela, A, Stulík, J, Hernychová, L

“…Natural resistance to Mycobacterium bovis bacillus Calmette-Guérin (BCG) is determined by the Bcg gene (Nramp1), which is exclusively expressed by mature…”
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Local antibodies and cytokine responses in crevicular fluid of patients with juvenile periodontitis by Bártová, J, Krejsa, O, Sirová, M, Tlaskalová, H, Procházková, J, Dusková, J

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