Assessment of femoral bone osteoporosis in rats treated with simvastatin or fenofibrate

Assessment of femoral bone osteoporosis in rats treated with simvastatin or fenofibrate

Background: The effects of two lipidlowering drugs, simvastatin and fenofibrate on osteoporosis in the femurs of healthy and ovariectomized female rats were investigated quantitatively by histological images and H NMR relaxometry. Methodology: The intertrabecular cavities percentage was estimated fr...

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Bibliographic Details
Published in:Open life sciences Vol. 10; no. 1
Main Authors: Şipos, Remus S., Fechete, Radu, Moldovan, Dumitriţa, Şuş, Ioana, Szasz, Simona, Pávai, Zoltán
Format: Journal Article
Language:English
Published: De Gruyter Open 21-08-2015
De Gruyter
Subjects:
1D T2 distribution analysis
histological images
NMR relaxometry
Osteoporosis
rat femurs
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Summary:Background: The effects of two lipidlowering drugs, simvastatin and fenofibrate on osteoporosis in the femurs of healthy and ovariectomized female rats were investigated quantitatively by histological images and H NMR relaxometry. Methodology: The intertrabecular cavities percentage was estimated from numerically cleaned histological images which initially present both the trabecular bone architecture and bone marrow filling the intertrabecular pores. The eight weeks evolution of intertrabecular cavities percentage measured from histological images of randomly selected sections in ovariectomized rats femoral diaphysis is similar with the evolution of transverse relaxation time centre of gravity T , a selected parameter to quantify the changes in intertrabecular cavities dimensions from onedimensional (1D) transverse relaxation time T distributions. Results: The analysis of histological images recorded for non-ovariectomized rats show that the treatment with simvastatin and fenofibrate has a negative effect on the dimension of the femoral diaphysis trabecular bone. The analysis of 1D T distributions show that the simvastatin and fenofibrate lipid-lowering drugs produce different effects on different particular sections of studied rat bones, i.e. proximal part of femoris, diaphysis or distal epiphysis. Conclusions: Finally, it is shown that the effects of the treatments are strongly dependent on the duration of treatment.
ISSN:2391-5412
2391-5412
DOI:10.1515/biol-2015-0039