Search Results - "Śmieja, Jarosław"

An engineering perspective on transcription, translation and their regulation by Śmieja, Jarosław

“…Information coded in DNA is replicated, modified and transmitted from the origins of protein-based life. Analogies of these processes to information…”
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Multiomics-Based Feature Extraction and Selection for the Prediction of Lung Cancer Survival by Jaksik, Roman, Szumała, Kamila, Dinh, Khanh Ngoc, Śmieja, Jarosław

“…Lung cancer is a global health challenge, hindered by delayed diagnosis and the disease's complex molecular landscape. Accurate patient survival prediction is…”
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Post-transcriptional regulatory feedback encodes JAK-STAT signal memory of interferon stimulation by Kalliara, Eirini, Kardynska, Malgorzata, Bagnall, James, Spiller, David G., Müller, Werner, Ruckerl, Dominik, Śmieja, Jarosław, Biswas, Subhra K., Paszek, Pawel

“…Immune cells fine tune their responses to infection and inflammatory cues. Here, using live-cell confocal microscopy and mathematical modelling, we investigate…”
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Quantitative analysis reveals crosstalk mechanisms of heat shock-induced attenuation of NF-κB signaling at the single cell level by Kardyńska, Małgorzata, Paszek, Anna, Śmieja, Jarosław, Spiller, David, Widłak, Wiesława, White, Michael R H, Paszek, Pawel, Kimmel, Marek

“…Elevated temperature induces the heat shock (HS) response, which modulates cell proliferation, apoptosis, the immune and inflammatory responses. However,…”
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Robustness of closed-loop glucose control systems by Wyciślok, Artur, Śmieja, Jarosław

“…The main purpose of this work is to provide an extensive, simulation-based comparison of robustness of PID and MPC algorithms in control of blood glucose…”
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Heat shock response regulates stimulus-specificity and sensitivity of the pro-inflammatory NF-κB signalling by Paszek, Anna, Kardyńska, Małgorzata, Bagnall, James, Śmieja, Jarosław, Spiller, David G, Widłak, Piotr, Kimmel, Marek, Widlak, Wieslawa, Paszek, Pawel

“…Ability to adapt to temperature changes trough the Heat Shock Response (HSR) pathways is one of the most fundamental and clinically relevant cellular response…”
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LMO1 polymorphisms and the risk of neuroblastoma: Assessment of meta‐analysis of case‐control studies by Hashemi, Mohammad, Sarabandi, Sahel, Karami, Shima, Śmieja, Jarosław, Moazeni‐Roodi, Abdolkarim, Ghavami, Saeid, Łos, Marek J.

“…Neuroblastoma (NB), a neuroendocrine tumour, is one of the most prevalent cancers in children. The link between LMO1 polymorphisms and NB has been investigated…”
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Chemically Homogenous Compounds with Antagonistic Properties at All α1-Adrenoceptor Subtypes but not β1-Adrenoceptor Attenuate Adrenaline-Induced Arrhythmia in Rats by Pytka, Karolina, Lustyk, Klaudia, Żmudzka, Elżbieta, Kotańska, Magdalena, Siwek, Agata, Zygmunt, Małgorzata, Dziedziczak, Agnieszka, Śniecikowska, Joanna, Olczyk, Adrian, Gałuszka, Adam, Śmieja, Jarosław, Waszkielewicz, Anna M, Marona, Henryk, Filipek, Barbara, Sapa, Jacek, Mogilski, Szczepan

“…Studies proved that among all α1-adrenoceptors, cardiac myocytes functionally express only α1A- and α1B-subtype. Scientists indicated that α1A-subtype blockade…”
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HBK-17, a 5-HT1A Receptor Ligand With Anxiolytic-Like Activity, Preferentially Activates ß-Arrestin Signaling by Pytka, Karolina, Głuch-Lutwin, Monika, Żmudzka, Elżbieta, Sałaciak, Kinga, Siwek, Agata, Niemczyk, Katarzyna, Walczak, Maria, Smolik, Magdalena, Olczyk, Adrian, Gałuszka, Adam, Śmieja, Jarosław, Filipek, Barbara, Sapa, Jacek, Kołaczkowski, Marcin, Pańczyk, Katarzyna, Waszkielewicz, Anna, Marona, Henryk

“…Numerous studies have proven that both stimulation and blockade of 5-HT 1A and the blockade of 5-HT 7 receptors might cause the anxiolytic-like effects. Biased…”
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Mathematical Modeling Support for Lung Cancer Therapy-A Short Review by Smieja, Jaroslaw

“…The paper presents a review of models that can be used to describe dynamics of lung cancer growth and its response to treatment at both cell population and…”
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Radiomic signature accurately predicts the risk of metastatic dissemination in late-stage non-small cell lung cancer by Wilk, Agata Małgorzata, Kozłowska, Emilia, Borys, Damian, D’Amico, Andrea, Fujarewicz, Krzysztof, Gorczewska, Izabela, Debosz-Suwinska, Iwona, Suwinski, Rafał, Smieja, Jarosław, Swierniak, Andrzej

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Quantitative analysis reveals crosstalk mechanisms of heat shock-induced attenuation of NF-KB signaling at the single cell level by Kardyńska, Małgorzata, Paszek, Anna, Śmieja, Jarosław, Spiller, David, Widłak, Wiesława, White, Michael R H, Paszek, Pawel, Kimmel, Marek

“…Elevated temperature induces the heat shock (HS) response, which modulates cell proliferation, apoptosis, the immune and inflammatory responses. However,…”
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Application of Sensitivity Analysis to Discover Potential Molecular Drug Targets by Kardynska, Malgorzata, Smieja, Jaroslaw, Paszek, Pawel, Puszynski, Krzysztof

“…Mathematical modeling of signaling pathways and regulatory networks has been supporting experimental research for some time now. Sensitivity analysis, aimed at…”
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Petri nets and ODEs as complementary methods for comprehensive analysis on an example of the ATM–p53–NF-κB signaling pathways by Gutowska, Kaja, Kogut, Daria, Kardynska, Malgorzata, Formanowicz, Piotr, Smieja, Jaroslaw, Puszynski, Krzysztof

“…Intracellular processes are cascades of biochemical reactions, triggered in response to various types of stimuli. Mathematical models describing their dynamics…”
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Mathematical modeling of regulatory networks of intracellular processes – Aims and selected methods by Kardynska, Malgorzata, Kogut, Daria, Pacholczyk, Marcin, Smieja, Jaroslaw

“…Regulatory networks structure and signaling pathways dynamics are uncovered in time- and resource consuming experimental work. However, it is increasingly…”
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HBK-17, a 5-HT 1A Receptor Ligand With Anxiolytic-Like Activity, Preferentially Activates ß-Arrestin Signaling by Pytka, Karolina, Głuch-Lutwin, Monika, Żmudzka, Elżbieta, Sałaciak, Kinga, Siwek, Agata, Niemczyk, Katarzyna, Walczak, Maria, Smolik, Magdalena, Olczyk, Adrian, Gałuszka, Adam, Śmieja, Jarosław, Filipek, Barbara, Sapa, Jacek, Kołaczkowski, Marcin, Pańczyk, Katarzyna, Waszkielewicz, Anna, Marona, Henryk

“…Numerous studies have proven that both stimulation and blockade of 5-HT and the blockade of 5-HT receptors might cause the anxiolytic-like effects. Biased…”
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Sensitivity analysis of signaling pathway models based on discrete-time measurements by Kardynska, Malgorzata, Smieja, Jaroslaw

“…The paper is focused on sensitivity analysis of large-scale models of biological systems that describe dynamics of the so called signaling pathways. These…”
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Mathematical modeling as a tool for planning anticancer therapy by Swierniak, Andrzej, Kimmel, Marek, Smieja, Jaroslaw

“…We review a large volume of literature concerning mathematical models of cancer therapy, oriented towards optimization of treatment protocols. The review,…”
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Sensitivity of signaling pathway dynamics to plasmid transfection and its consequences by Smieja, Jaroslaw, Dolbniak, Marzena

“…This paper deals with development of signaling pathways models and using plasmid-based experiments to support parameter estimation. We show that if cells…”
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Modeling epigenetic regulation of PRC1 protein accumulation in the cell cycle by Dolbniak, Marzena, Kimmel, Marek, Smieja, Jaroslaw

“…Epigenetic regulation contributes to many important processes in biological cells. Examples include developmental processes, differentiation and maturation of…”
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