Search Results - "Őrfi, Lászlȯ"

Activation of HER3 Interferes with Antitumor Effects of Axl Receptor Tyrosine Kinase Inhibitors: Suggestion of Combination Therapy by Torka, Robert, Pénzes, Kinga, Gusenbauer, Simone, Baumann, Christine, Szabadkai, István, Őrfi, Lászlȯ, Kéri, György, Ullrich, Axel

“…Abstract The Axl receptor tyrosine kinase (RTK) has been established as a strong candidate for targeted therapy of cancer. However, the benefits of targeted…”
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Synthesis and Evaluation of Phosphorus Containing, Specific CDK9/CycT1 Inhibitors by Németh, Gábor, Greff, Zoltán, Sipos, Anna, Varga, Zoltán, Székely, Rita, Sebestyén, Mónika, Jászay, Zsuzsa, Béni, Szabolcs, Nemes, Zoltán, Pirat, Jean-Luc, Volle, Jean-Noël, Virieux, David, Gyuris, Ágnes, Kelemenics, Katalin, Áy, Éva, Minarovits, Janos, Szathmary, Susan, Kéri, György, Őrfi, László

“…Although there is a significant effort in the design of a selective CDK9/CycT1 inhibitor, no compound has been proven to be a specific inhibitor of this kinase…”
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Sigma-1 Receptor Agonist Fluvoxamine Ameliorates Fibrotic Response of Trabecular Meshwork Cells by Hodrea, Judit, Tran, Minh Ngoc, Besztercei, Balazs, Medveczki, Timea, Szabo, Attila J, Őrfi, Laszlo, Kovacs, Illes, Fekete, Andrea

“…Primary open-angle glaucoma remains a global issue, lacking a definitive treatment. Increased intraocular pressure (IOP) is considered the primary risk factor…”
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AXL Is a Potential Target for Therapeutic Intervention in Breast Cancer Progression by ZHANG, Yi-Xiang, KNYAZEV, Peter G, CHEBURKIN, Yuri V, SHARMA, Kirti, KNYAZEV, Yuri P, ORFI, Laszlo, SZABADKAI, Istvan, DAUB, Henrik, KERI, György, ULLRICH, Axel

“…Protein kinases play important roles in tumor development and progression. A variety of members of this family of signal transduction enzymes serve as targets…”
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Optimization of Sirius Red-Based Microplate Assay to Investigate Collagen Production In Vitro by Szász, Csenge, Pap, Domonkos, Szebeni, Beáta, Bokrossy, Péter, Őrfi, László, Szabó, Attila J, Vannay, Ádám, Veres-Székely, Apor

“…Tissue fibrosis is characterized by chronic fibroblast activation and consequently excessive accumulation of collagen-rich extracellular matrix. In vitro…”
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Anticytolytic Screen Identifies Inhibitors of Mycobacterial Virulence Protein Secretion by Rybniker, Jan, Chen, Jeffrey M., Sala, Claudia, Hartkoorn, Ruben C., Vocat, Anthony, Benjak, Andrej, Boy-Röttger, Stefanie, Zhang, Ming, Székely, Rita, Greff, Zoltán, Őrfi, László, Szabadkai, István, Pató, János, Kéri, György, Cole, Stewart T.

“…Mycobacterium tuberculosis (Mtb) requires protein secretion systems like ESX-1 for intracellular survival and virulence. The major virulence determinant and…”
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Integrating molecular diagnostics into anticancer drug discovery by Peták, István, Schwab, Richárd, Őrfi, László, Kopper, László, Kéri, György

“…Efforts to repeat the success of pioneering molecularly targeted cancer drugs, such as trastuzumab, for particular patient populations have been hampered by…”
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The role of PI3K-Akt-mTOR axis in Warburg effect and its modification by specific protein kinase inhibitors in human and rat inflammatory macrophages by Bögel, Gábor, Sváb, Gergely, Murányi, József, Szokol, Bálint, Kukor, Zoltán, Kardon, Tamás, Őrfi, László, Tretter, László, Hrabák, András

“…•Expression of HIF-1α, NOS2 and inflammatory cytokines increased in inflammatory macrophages.•Increased expressions of HIF-1α, NOS2 and IP-10 were reduced by…”
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Transient Agarose Spot (TAS) Assay: A New Method to Investigate Cell Migration by Veres-Székely, Apor, Pap, Domonkos, Szebeni, Beáta, Őrfi, László, Szász, Csenge, Pajtók, Csenge, Lévai, Eszter, Szabó, Attila J, Vannay, Ádám

“…Fibroblasts play a central role in diseases associated with excessive deposition of extracellular matrix (ECM), including idiopathic pulmonary fibrosis…”
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A Closer Look at the Structure of Sterically Stabilized Liposomes: A Small-Angle X-ray Scattering Study by Varga, Zoltán, Berényi, Szilvia, Szokol, Bálint, Őrfi, László, Kéri, György, Peták, István, Hoell, Armin, Bóta, Attila

“…The evaluation of the radial electron density profile of a drug containing a sterically stabilized liposomal system is described. Using synchrotron small-angle…”
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Characterization of new, efficient Mycobacterium tuberculosis topoisomerase-I inhibitors and their interaction with human ABC multidrug transporters by Temesszentandrási-Ambrus, Csilla, Tóth, Szilárd, Verma, Rinkee, Bánhegyi, Péter, Szabadkai, István, Baska, Ferenc, Szántai-Kis, Csaba, Hartkoorn, Ruben C, Lingerfelt, Mary A, Sarkadi, Balázs, Szakács, Gergely, Őrfi, László, Nagaraja, Valakunja, Ekins, Sean, Telbisz, Ágnes

“…Drug resistant tuberculosis (TB) is a major worldwide health problem. In addition to the bacterial mechanisms, human drug transporters limiting the cellular…”
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Small-Molecule Inhibitors of NADPH Oxidase 4 by Borbély, Gábor, Szabadkai, István, Horváth, Zoltán, Markó, Péter, Varga, Zoltán, Breza, Nóra, Baska, Ferenc, Vántus, Tibor, Huszár, Mónika, Geiszt, Miklós, Hunyady, László, Buday, László, Őrfi, László, Kéri, György

“…NOX enzymes are the major contributors in many oxidative damage related diseases. Unfortunately, at present no specific NOX inhibitor is available. Here, we…”
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Interaction of the EGFR inhibitors gefitinib, vandetanib, pelitinib and neratinib with the ABCG2 multidrug transporter: Implications for the emergence and reversal of cancer drug resistance by Hegedüs, Csilla, Truta-Feles, Krisztina, Antalffy, Géza, Várady, György, Német, Katalin, Özvegy-Laczka, Csilla, Kéri, György, Őrfi, László, Szakács, Gergely, Settleman, Jeffrey, Váradi, András, Sarkadi, Balázs

“…(A) ABCG2 confers gefitinib or pelitinib resistance. Intracellular efficiency of neratinib or vandetanib is not restricted by ABCG2. (B) EGFR inhibitors block…”
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Design and synthesis of new imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrazine derivatives with antiproliferative activity against melanoma cells by Garamvölgyi, Rita, Dobos, Judit, Sipos, Anna, Boros, Sándor, Illyés, Eszter, Baska, Ferenc, Kékesi, László, Szabadkai, István, Szántai-Kis, Csaba, Kéri, György, Őrfi, László

“…Melanoma is an aggressive form of skin cancer and it is generally associated with poor prognosis in patients with late-stage disease. Due to the increasing…”
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DNA binding of sunitinib: Spectroscopic evidence via circular dichroism and nuclear magnetic resonance by Kiss, Eszter, Mirzahosseini, Arash, Hubert, Ágnes, Ambrus, Attila, Őrfi, László, Horváth, Péter

“…•Plasmid DNA can be used in DNA-ligand binding experiments with certain considerations.•A two-step binding mechanism is proposed for sunitinib.•In the first…”
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Synthesis and evaluation of a new class of MIF-inhibitors in activated macrophage cells and in experimental septic shock in mice by Garai, János, Radnai, Balázs, Vámos, Eszter, Kovács, Dominika, Vántus, Viola Bagóné, Rumbus, Zoltán, Pákai, Eszter, Garami, András, Gulyás-Fekete, Gergely, Agócs, Attila, Krekó, Marcell, Zaman, Khadiza, Prókai, László, Őrfi, László, Jakus, Péter B., Lóránd, Tamás

“…Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine with enzymatic activities. Anti-inflammatory effects of MIF enzyme inhibitors…”
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Targeted drug combination therapy design based on driver genes by Zsákai, Lilian, Sipos, Anna, Dobos, Judit, Erős, Dániel, Szántai-Kis, Csaba, Bánhegyi, Péter, Pató, János, Őrfi, László, Matula, Zsolt, Mikala, Gábor, Kéri, György, Peták, István, Vályi-Nagy, István

“…Targeted therapies against cancer types with more than one driver gene hold bright but elusive promise, since approved drugs are not available for all driver…”
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Small molecule somatostatin receptor subtype 4 (sst4) agonists are novel anti-inflammatory and analgesic drug candidates by Szőke, Éva, Bálint, Mónika, Hetényi, Csaba, Markovics, Adrienn, Elekes, Krisztián, Pozsgai, Gábor, Szűts, Tamás, Kéri, György, Őrfi, László, Sándor, Zoltán, Szolcsányi, János, Pintér, Erika, Helyes, Zsuzsanna

“…We provided strong proof of concept evidence that somatostatin mediates potent analgesic and anti-inflammatory actions via its receptor subtype 4 (sst4)…”
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Leads for antitubercular compounds from kinase inhibitor library screens by Magnet, Sophie, Hartkoorn, Ruben C, Székely, Rita, Pató, János, Triccas, James A, Schneider, Patricia, Szántai-Kis, Csaba, Őrfi, László, Chambon, Marc, Banfi, Damiano, Bueno, Manuel, Turcatti, Gerardo, Kéri, György, Cole, Stewart T

“…Summary Discovering new drugs to treat tuberculosis more efficiently and to overcome multidrug resistance is a world health priority. To find antimycobacterial…”
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Chemoenzymatic route to Tyrphostins involving lipase-catalyzed kinetic resolution of 1-phenylethanamine with alkyl cyanoacetates as novel acylating agents by Csuka, Pál, Boros, Zoltán, Őrfi, László, Dobos, Judit, Poppe, László, Hornyánszky, Gábor

“…[Display omitted] Ethyl and isopropyl cyanoacetates were tested as acylating agents in the kinetic resolution of racemic 1-phenylethanamine rac-1 catalyzed by…”
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