Search Results - "Łegowska, A."

Conformational studies of [Nphe5]SFTI-1 by means of 2D NMR spectroscopy in conjunction with molecular dynamics calculations by Brzozowski, K., Stawikowski, M., Ślusarz, R., Sikorska, E., Lesner, A., Łęgowska, A., Rolka, K.

“…Trypsin inhibitor SFTI-1 is the smallest and the most potent among BBI inhibitors. It is also an interesting object for SAR studies since it is cyclic 14 amino…”
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Substrate specificity and inhibitory study of human airway trypsin-like protease by Wysocka, M., Spichalska, B., Lesner, A., Jaros, M., Brzozowski, K., Łęgowska, A., Rolka, K.

“…Human airway trypsin-like protease (HAT), also referred to as TMPRSS11D, is an important physiological enzyme with the main activity pronounced in an airway…”
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Hybrid analogues of SFTI‐1 modified in P 1 position by β‐ and γ‐amino acids and N ‐substituted β‐alanines by Debowski, D., Łukajtis, R., Filipowicz, M., Strzelecka, P., Wysocka, M., Łęgowska, A., Lesner, A., Rolka, K.

“…A series of compounds containing either non‐proteinogenic β‐/γ‐amino acids or N ‐substituted β‐alanine residues (β‐peptoid units) in P 1 specificity position…”
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Hybrid analogues of SFTI-1 modified in P1 position by β- and γ-amino acids and N-substituted β-alanines by Debowski, D., Łukajtis, R., Filipowicz, M., Strzelecka, P., Wysocka, M., Łęgowska, A., Lesner, A., Rolka, K.

“…A series of compounds containing either non‐proteinogenic β‐/γ‐amino acids or N‐substituted β‐alanine residues (β‐peptoid units) in P1 specificity position…”
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Orphanin FQ/nociceptin but not Ro 65-6570 inhibits the expression of cocaine-induced conditioned place preference by Kotlińska, J, Wichmann, J, Legowska, A, Rolka, K, Silberring, J

“…The present study investigated the effect of orphanin FQ/nociceptin (OFQ/N), the endogenous ligand of the opioid receptor-like 1 (ORL-1) receptor on the…”
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Solution conformational study of Scyliorhinin I analogues with conformational constraints by two-dimensional NMR and theoretical conformational analysis by Rodziewicz-Motowidło, S., Łegowska, A., Qi, X.-F., Czaplewski, C., Liwo, A., Rolka, K., Sowiński, P., Mozga, W., Olczak, J., Zabrocki, J.

“…Two analogues of Scyliorhinin I (ScyI), a tachykinin with N‐MeLeu in position 8 and a 1,5‐disubstituted tetrazole ring between positions 7 and 8, introduced in…”
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Orphanin FQ/nociceptin inhibits morphine withdrawal by Kotlińska, Jolanta, Suder, Piotr, Legowska, Agnieszka, Rolka, Krzysztof, Silberring, Jerzy

“…The influence of orphanin FQ/nociceptin (OFQ/N) on the morphine-withdrawal symptom was investigated. Withdrawal syndrome was induced in the morphine-dependent…”
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C-Terminal glycine is crucial for hyperalgesic activity of nociceptin/orphanin FQ-(1–6) by Kotlińska, Jolanta, Suder, Piotr, Sciubisz, Agnieszka, Łęgowska, Anna, Eilmes, Julita, Rolka, Krzysztof, Silberring, Jerzy

“…A C-terminal analog of the hexapeptide orphanin FQ/nociceptin-(1–6), [Ala 6]-orphanin FQ/nociceptin-(1–6), and a pentapeptide orphanin FQ/nociceptin-(1–5) were…”
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Conformational solution studies of neuropeptide γ using CD and NMR spectroscopy by Rodziewicz-Motowidło, Sylwia, Brzozowski, Krzysztof, Łęgowska, Anna, Liwo, Adam, Silbering, Jerzy, Smoluch, Marek, Rolka, Krzysztof

“…Neuropeptide γ is one of the largest members of the tachykinin family of peptides, exhibiting strong agonistic activity towards the NK‐2 tachykinin receptor…”
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Dynorphin A Inhibits Nociceptin-Converting Enzyme from the Rat Spinal Cord by Suder, Piotr, Wade, David, Łęgowska, Anna, Kotlińska, Jolanta, Rolka, Krzysztof, Silberring, Jerzy

“…Cysteine proteinase found in the spinal cord of rat, called nociceptin-converting enzyme (NCE), is competitively inhibited by dynorphin A and its fragment…”
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Synthesis, activity on NK-3 tachykinin receptor and conformational solution studies of scyliorhinin II analogs modified at position 16 by Rodziewicz-Motowidło, S., Lesner, A., Łęgowska, A., Czaplewski, C., Liwo, A., Rolka, K., Patacchini, R., Quartara, L.

“…: Two analogs of a tachykinin family peptides – scyliorhinin II (ScyII): [Aib16]ScyII and [Sar16]ScyII were synthesized by the solid‐phase method using Fmoc…”
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Determination of nociceptin–orphanin FQ metabolites by capillary LC–MS by Suder, P, Kotlińska, J, Łȩgowska, A, Smoluch, M, Höhne, G, Chervet, J.-P, Rolka, K, Silberring, J

“…Nociceptin–orphanin FQ (OFQ/N) is a newly discovered peptide involved in pain transmission. The method is described to identify metabolic pathway of this…”
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Effects of new somatostatin analogs on the cell proliferation of colonic crypts and colonic cancers in rats by Zerek-Mełeń, G, Pawlikowski, M, Winczyk, K, Lachowicz-Ochedalska, A, Legowska, A, Kwaśny, H, Przybylski, J, Szadowska, A

“…The antiproliferative activity of two new somatostatin (SS) analogs: ASS-51 and ASS-52 have been tested in this study. We assessed their ability to inhibit the…”
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The dimeric and tetrameric octarepeat fragments of prion protein behave differently to its monomeric unit by Valensin, Daniela, Luczkowski, Marek, Mancini, Francesca Maria, Legowska, Anna, Gaggelli, Elena, Valensin, Gianni, Rolka, Krzysztof, Kozlowski, Henryk

“…Potentiometric and spectroscopic data have shown that octarepeat dimer and tetramer are much more effective ligands for Cu(II) ions than simple octapeptide…”
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Trypsin inhibitors from the garden four o’clock ( Mirabilis jalapa) and spinach ( Spinacia oleracea) seeds: Isolation, characterization and chemical synthesis by Kowalska, Jolanta, Pszczoła, Katarzyna, Wilimowska-Pelc, Anna, Lorenc-Kubis, Irena, Zuziak, Ewa, Ługowski, Mateusz, Łęgowska, Anna, Kwiatkowska, Anna, Śleszyńska, Małgorzata, Lesner, Adam, Walewska, Aleksandra, Zabłotna, Ewa, Rolka, Krzysztof, Wilusz, Tadeusz

“…Five trypsin inhibitors from the ripe seeds of the garden four-o’clock and spinach were isolated. The primary structures and disulfide bridge pattern were…”
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Solution conformational study of nociceptin an(d its 1-13 and 1-11 fragments using circular dichroism and two-dimensional NMR in conjunction with theoretical conformational analysis by Klaudel, Lidia, Legowska, Anna, Brzozowski, Krzysztof, Silberring, Jerzy, Wójcik, Jacek

“…Conformational studies of nociceptin (NC-NH2), its fully active fragment, NC(1-13)-NH2, and two significantly less potent fragments, NC(1-13)-OH and…”
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The prion peptide forms ion channels in planar lipid bilayers by Berest, Vladimir, Rutkowski, Marcin, Rolka, Krzysztof, Łegowska, Anna, Debska, Grazyna, Stepkowski, Dariusz, Szewczyk, Adam

“…One of the hypotheses concerning the pathogenic properties of the prion protein considers its influence on cellular ion homeostasis. Using the lipid bilayer…”
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