Search Results - "Łażewska, Dorota"

Potent, Selective Agonists for the Cannabinoid-like Orphan G Protein-Coupled Receptor GPR18: A Promising Drug Target for Cancer and Immunity by Mahardhika, Andhika B., Załuski, Michal, Schoeder, Clara T., Boshta, Nader M., Schabikowski, Jakub, Perri, Filomena, Łażewska, Dorota, Neumann, Alexander, Kremers, Sarah, Oneto, Angelo, Ressemann, Anastasiia, Latacz, Gniewomir, Namasivayam, Vigneshwaran, Kieć-Kononowicz, Katarzyna, Müller, Christa E.

“…The human orphan G protein-coupled receptor GPR18, activated by Δ9-tetrahydrocannabinol (THC), constitutes a promising drug target in immunology and cancer…”
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The Dual-Active Histamine H3 Receptor Antagonist and Acetylcholine Esterase Inhibitor E100 Alleviates Autistic-Like Behaviors and Oxidative Stress in Valproic Acid Induced Autism in Mice by Eissa, Nermin, Azimullah, Sheikh, Jayaprakash, Petrilla, Jayaraj, Richard L., Reiner, David, Ojha, Shreesh K., Beiram, Rami, Stark, Holger, Łażewska, Dorota, Kieć-Kononowicz, Katarzyna, Sadek, Bassem

“…The histamine H3 receptor (H3R) functions as auto- and hetero-receptors, regulating the release of brain histamine (HA) and acetylcholine (ACh), respectively…”
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Dual Piperidine-Based Histamine H3 and Sigma‑1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain by Szczepańska, Katarzyna, Karcz, Tadeusz, Dichiara, Maria, Mogilski, Szczepan, Kalinowska-Tłuścik, Justyna, Pilarski, Bogusław, Leniak, Arkadiusz, Pietruś, Wojciech, Podlewska, Sabina, Popiołek-Barczyk, Katarzyna, Humphrys, Laura J., Ruiz-Cantero, M. Carmen, Reiner-Link, David, Leitzbach, Luisa, Łażewska, Dorota, Pockes, Steffen, Górka, Michał, Zmysłowski, Adam, Calmels, Thierry, Cobos, Enrique J., Marrazzo, Agostino, Stark, Holger, Bojarski, Andrzej J., Amata, Emanuele, Kieć-Kononowicz, Katarzyna

“…In search of new dual-acting histamine H3/sigma-1 receptor ligands, we designed a series of compounds structurally based on highly active in vivo ligands…”
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Multitargeting Histamine H3 Receptor Ligands among Acetyl- and Propionyl-Phenoxyalkyl Derivatives by Łażewska, Dorota, Kaleta, Maria, Zaręba, Paula, Godyń, Justyna, Dubiel, Mariam, Honkisz-Orzechowska, Ewelina, Doroz-Płonka, Agata, Więckowska, Anna, Stark, Holger, Kieć-Kononowicz, Katarzyna

“…Alzheimer’s disease (AD) is a neurodegenerative disorder, for which there is no effective cure. Current drugs only slow down the course of the disease, and,…”
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New Triazine Derivatives as Serotonin 5-HT6 Receptor Ligands by Łażewska, Dorota, Więcek, Małgorzata, Satała, Grzegorz, Chałupnik, Paulina, Żesławska, Ewa, Honkisz-Orzechowska, Ewelina, Tarasek, Monika, Latacz, Gniewomir, Nitek, Wojciech, Szymańska, Ewa, Handzlik, Jadwiga

“…Since the number of people with Alzheimer’s disease (AD) continues to rise, new and effective drugs are urgently needed to not only slow down the progression…”
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Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H3 and Sigma‑1 Receptor Antagonists with Promising Antinociceptive Properties by Szczepańska, Katarzyna, Podlewska, Sabina, Dichiara, Maria, Gentile, Davide, Patamia, Vincenzo, Rosier, Niklas, Mönnich, Denise, Ruiz Cantero, M, Karcz, Tadeusz, Łażewska, Dorota, Siwek, Agata, Pockes, Steffen, Cobos, Enrique J, Marrazzo, Agostino, Stark, Holger, Rescifina, Antonio, Bojarski, Andrzej J, Amata, Emanuele, Kieć-Kononowicz, Katarzyna

“…In an attempt to extend recent studies showing that some clinically evaluated histamine H3 receptor (H3R) antagonists possess nanomolar affinity at sigma-1…”
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AR71, Histamine H3 Receptor Ligand—In Vitro and In Vivo Evaluation (Anti-Inflammatory Activity, Metabolic Stability, Toxicity, and Analgesic Action) by Stasiak, Anna, Honkisz-Orzechowska, Ewelina, Gajda, Zbigniew, Wagner, Waldemar, Popiołek-Barczyk, Katarzyna, Kuder, Kamil J., Latacz, Gniewomir, Juszczak, Michał, Woźniak, Katarzyna, Karcz, Tadeusz, Szczepańska, Katarzyna, Jóźwiak-Bębenista, Marta, Kieć-Kononowicz, Katarzyna, Łażewska, Dorota

“…The future of therapy for neurodegenerative diseases (NDs) relies on new strategies targeting multiple pharmacological pathways. Our research led to obtaining…”
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Anti-Inflammatory Activities of 8-Benzylaminoxanthines Showing High Adenosine A2A and Dual A1/A2A Receptor Affinity by Załuski, Michał, Łażewska, Dorota, Jaśko, Piotr, Honkisz-Orzechowska, Ewelina, Kuder, Kamil J., Brockmann, Andreas, Latacz, Gniewomir, Zygmunt, Małgorzata, Kaleta, Maria, Greser, Beril Anita, Olejarz-Maciej, Agnieszka, Jastrzębska-Więsek, Magdalena, Vielmuth, Christin, Müller, Christa E., Kieć-Kononowicz, Katarzyna

“…Chronic inflammation plays an important role in the development of neurodegenerative diseases, such as Parkinson’s disease (PD). In the present study, we…”
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Reproductive and fetal toxicity studies of histamine H3 receptor antagonist DL76 used in mice to prevent maximal electroshock-induced seizure by Bastaki, Salim M, Abdulrazzaq, Yousef M, Zidan, Marwan Abdelrahim, Shafiullah, Mohamed, Alaryani, Saif Ghdayer, Alnuaimi, Fatima Awad, Adeghate, Ernest, Mohsin, Sahar, Akour, Amal, Siwek, Agata, Łażewska, Dorota, Kieć-Kononowicz, Katarzyna, Sadek, Bassem

“…Brain histamine is considered an endogenous anticonvulsant and histamine H1 receptor. H1R antagonists have, in earlier studies, been found to induce…”
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Rational design of new multitarget histamine H 3 receptor ligands as potential candidates for treatment of Alzheimer's disease by Łażewska, Dorota, Bajda, Marek, Kaleta, Maria, Zaręba, Paula, Doroz-Płonka, Agata, Siwek, Agata, Alachkar, Alaa, Mogilski, Szczepan, Saad, Ali, Kuder, Kamil, Olejarz-Maciej, Agnieszka, Godyń, Justyna, Stary, Dorota, Sudoł, Sylwia, Więcek, Małgorzata, Latacz, Gniewomir, Walczak, Maria, Handzlik, Jadwiga, Sadek, Bassem, Malawska, Barbara, Kieć-Kononowicz, Katarzyna

“…Design and development of multitarget-directed ligands (MTDLs) has become a very important approach in the search of new therapies for Alzheimer's disease…”
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Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HT6 by Ali, Wesam, Więcek, Małgorzata, Łażewska, Dorota, Kurczab, Rafał, Jastrzębska-Więsek, Magdalena, Satała, Grzegorz, Kucwaj-Brysz, Katarzyna, Lubelska, Annamaria, Głuch-Lutwin, Monika, Mordyl, Barbara, Siwek, Agata, Nasim, Muhammad Jawad, Partyka, Anna, Sudoł, Sylwia, Latacz, Gniewomir, Wesołowska, Anna, Kieć-Kononowicz, Katarzyna, Handzlik, Jadwiga

“…This research has provided the most active 5-HT6R agents among 1,3,5-triazine derivatives investigated to date and has also identified the world's first…”
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Trisubstituted 1,3,5-Triazines as Histamine H4 Receptor Antagonists with Promising Activity In Vivo by Olejarz-Maciej, Agnieszka, Mogilski, Szczepan, Karcz, Tadeusz, Werner, Tobias, Kamińska, Katarzyna, Kupczyk, Jarosław, Honkisz-Orzechowska, Ewelina, Latacz, Gniewomir, Stark, Holger, Kieć-Kononowicz, Katarzyna, Łażewska, Dorota

“…Pain is a very unpleasant experience that makes life extremely uncomfortable. The histamine H4 receptor (H4R) is a promising target for the treatment of…”
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Role of Histamine H₃ Receptor Antagonists on Intraocular Pressure Reduction in Rabbit Models of Transient Ocular Hypertension and Glaucoma by Lanzi, Cecilia, Lucarini, Laura, Durante, Mariaconcetta, Sgambellone, Silvia, Pini, Alessandro, Catarinicchia, Stefano, Łażewska, Dorota, Kieć-Kononowicz, Katarzyna, Stark, Holger, Masini, Emanuela

“…Intraocular pressure (IOP) has a tendency to fluctuate throughout the day, reaching its peak in the early morning in healthy subjects or glaucoma patients…”
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Benzophenone Derivatives with Histamine H3 Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer’s Disease by Godyń, Justyna, Zaręba, Paula, Stary, Dorota, Kaleta, Maria, Kuder, Kamil J., Latacz, Gniewomir, Mogilski, Szczepan, Reiner-Link, David, Frank, Annika, Doroz-Płonka, Agata, Olejarz-Maciej, Agnieszka, Sudoł-Tałaj, Sylwia, Nolte, Tobias, Handzlik, Jadwiga, Stark, Holger, Więckowska, Anna, Malawska, Barbara, Kieć-Kononowicz, Katarzyna, Łażewska, Dorota, Bajda, Marek

“…The multitarget-directed ligands demonstrating affinity to histamine H3 receptor and additional cholinesterase inhibitory potency represent a promising…”
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Biphenylalkoxyamine Derivatives–Histamine H3 Receptor Ligands with Butyrylcholinesterase Inhibitory Activity by Łażewska, Dorota, Zaręba, Paula, Godyń, Justyna, Doroz-Płonka, Agata, Frank, Annika, Reiner-Link, David, Bajda, Marek, Stary, Dorota, Mogilski, Szczepan, Olejarz-Maciej, Agnieszka, Kaleta, Maria, Stark, Holger, Malawska, Barbara, Kieć-Kononowicz, Katarzyna

“…Neurodegenerative diseases, e.g., Alzheimer’s disease (AD), are a key health problem in the aging population. The lack of effective therapy and diagnostics…”
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Dual Target Ligands with 4-tert-Butylphenoxy Scaffold as Histamine H3 Receptor Antagonists and Monoamine Oxidase B Inhibitors by Łażewska, Dorota, Olejarz-Maciej, Agnieszka, Reiner, David, Kaleta, Maria, Latacz, Gniewomir, Zygmunt, Małgorzata, Doroz-Płonka, Agata, Karcz, Tadeusz, Frank, Annika, Stark, Holger, Kieć-Kononowicz, Katarzyna

“…Dual target ligands are a promising concept for the treatment of Parkinson’s disease (PD). A combination of monoamine oxidase B (MAO B) inhibition with…”
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Benzophenone Derivatives with Histamine H 3 Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer's Disease by Godyń, Justyna, Zaręba, Paula, Stary, Dorota, Kaleta, Maria, Kuder, Kamil J, Latacz, Gniewomir, Mogilski, Szczepan, Reiner-Link, David, Frank, Annika, Doroz-Płonka, Agata, Olejarz-Maciej, Agnieszka, Sudoł-Tałaj, Sylwia, Nolte, Tobias, Handzlik, Jadwiga, Stark, Holger, Więckowska, Anna, Malawska, Barbara, Kieć-Kononowicz, Katarzyna, Łażewska, Dorota, Bajda, Marek

“…The multitarget-directed ligands demonstrating affinity to histamine H receptor and additional cholinesterase inhibitory potency represent a promising strategy…”
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Law and Literature.The Places for Metaphysical Thinking by Łażewska, Dorota

“…Objectives The aim of this study is to identify places of metaphysical thinking in law and in literature.As metaphysical thinking is the search for the causes…”
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Dual Targeting Ligands—Histamine H3 Receptor Ligands with Monoamine Oxidase B Inhibitory Activity—In Vitro and In Vivo Evaluation by Łażewska, Dorota, Siwek, Agata, Olejarz-Maciej, Agnieszka, Doroz-Płonka, Agata, Wiktorowska-Owczarek, Anna, Jóźwiak-Bębenista, Marta, Reiner-Link, David, Frank, Annika, Sromek-Trzaskowska, Wioletta, Honkisz-Orzechowska, Ewelina, Królicka, Ewelina, Stark, Holger, Wieczorek, Marek, Wagner, Waldemar, Kieć-Kononowicz, Katarzyna, Stasiak, Anna

“…The clinical symptoms of Parkinson’s disease (PD) appear when dopamine (DA) concentrations in the striatum drops to around 20%. Simultaneous inhibitory effects…”
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Anticonvulsant and procognitive properties of the non-imidazole histamine H3 receptor antagonist DL77 in male adult rats by Sadek, Bassem, Saad, Ali, Subramanian, Dhanasekaran, Shafiullah, Mohamed, Łażewska, Dorota, Kieć-Kononowiczc, Katarzyna

“…It has become clear that histamine H3 receptors (H3Rs) are implicated in modulating epilepsy and memory in laboratory animals. The new non-imidazole H3R…”
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