Executive and verbal working memory dysfunction in first-degree relatives of patients with bipolar disorder

Executive and verbal working memory dysfunction in first-degree relatives of patients with bipolar disorder

Abstract The authors aimed to investigate cognitive performance of first-degree relatives of probands with bipolar disorder (BD). They hypothesized that the relatives of BD patients would have impaired performance on cognitive tests of frontal-executive functions. A neuropsychological battery was ad...

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Bibliographic Details
Published in:Psychiatry research Vol. 161; no. 3; pp. 318 - 324
Main Authors: Bora, Emre, Vahip, Simavi, Akdeniz, Fisun, İlerisoy, Hatice, Aldemir, Ebru, Alkan, Müge
Format: Journal Article
Language:English
Published: Kidlington Elsevier Ireland Ltd 15-12-2008
Elsevier
Subjects:
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Bipolar disorder
Bipolar Disorder - diagnosis
Bipolar Disorder - genetics
Bipolar Disorder - psychology
Bipolar disorders
Cognition Disorders - diagnosis
Cognition Disorders - genetics
Cognition Disorders - psychology
Discrimination Learning
Executive function
Female
Genetic Predisposition to Disease - genetics
Genetic Predisposition to Disease - psychology
Humans
Male
Medical sciences
Memory, Short-Term
Middle Aged
Mood disorders
Neuropsychology
Problem Solving
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychomotor Performance
Psychopathology. Psychiatry
Relatives
Set (Psychology)
Sustained attention
Verbal Learning
Working memory
Bipolar disorder
Executive function
Relatives
Sustained attention
Neuropsychology
Working memory
Mood disorder
Human
Cognitive disorder
Genetic marker
Family study
Cognition
Vulnerability
Genetic determinism
Verbal memory
Language
Cross sectional study
Genetics
Neuropsychologia
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Summary:Abstract The authors aimed to investigate cognitive performance of first-degree relatives of probands with bipolar disorder (BD). They hypothesized that the relatives of BD patients would have impaired performance on cognitive tests of frontal-executive functions. A neuropsychological battery was administered to 34 first-degree relatives of BD probands and 25 control subjects. Relatives showed significant impairment in verbal working memory and executive function. Verbal memory and psychomotor performances of relatives were not different from control subjects. One particular component of executive function, cognitive flexibility, was associated with family history of mood episodes with psychotic features. Verbal working memory and executive function deficits may be useful endophenotypic markers of genetic vulnerability to BD.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2007.09.002