Diverse SARS-CoV-2 variants preceded the initial COVID-19 outbreak in Croatia

We developed a next-generation SARS-CoV-2 sequencing platform and obtained the first SARS-CoV-2 sequences from patients in Croatia at the beginning of the COVID-19 outbreak in the spring of 2020. Integrating the sequencing and the epidemiological data, we show that patients were infected with differ...

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Bibliographic Details
Published in:Archives of virology Vol. 166; no. 6; pp. 1735 - 1739
Main Authors: Rokić, Filip, Trgovec-Greif, Lovro, Sučić, Neven, Čemeljić, Noa, Grbeša, Đurđica Cekinović, Svedružić, Željko, Rukavina, Tomislav, Vugrek, Oliver, Jurak, Igor
Format: Journal Article
Language:English
Published: Vienna Springer Vienna 01-06-2021
Springer Nature B.V
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Summary:We developed a next-generation SARS-CoV-2 sequencing platform and obtained the first SARS-CoV-2 sequences from patients in Croatia at the beginning of the COVID-19 outbreak in the spring of 2020. Integrating the sequencing and the epidemiological data, we show that patients were infected with different SARS-CoV-2 variants belonging to different clades (mostly G and GH). This result confirms that there was widespread virus transmission early in 2020. Interestingly, we identified a unique mutation resulting in a V13I substitution in Nsp5A, the main viral protease, in a patient who had not received antiviral therapy.
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Handling Editor: Zhenhai Chen.
ISSN:0304-8608
1432-8798
1432-8798
DOI:10.1007/s00705-021-05029-7