Diverse SARS-CoV-2 variants preceded the initial COVID-19 outbreak in Croatia
We developed a next-generation SARS-CoV-2 sequencing platform and obtained the first SARS-CoV-2 sequences from patients in Croatia at the beginning of the COVID-19 outbreak in the spring of 2020. Integrating the sequencing and the epidemiological data, we show that patients were infected with differ...
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Published in: | Archives of virology Vol. 166; no. 6; pp. 1735 - 1739 |
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Main Authors: | , , , , , , , , |
Format: | Journal Article |
Language: | English |
Published: |
Vienna
Springer Vienna
01-06-2021
Springer Nature B.V |
Subjects: | |
Online Access: | Get full text |
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Summary: | We developed a next-generation SARS-CoV-2 sequencing platform and obtained the first SARS-CoV-2 sequences from patients in Croatia at the beginning of the COVID-19 outbreak in the spring of 2020. Integrating the sequencing and the epidemiological data, we show that patients were infected with different SARS-CoV-2 variants belonging to different clades (mostly G and GH). This result confirms that there was widespread virus transmission early in 2020. Interestingly, we identified a unique mutation resulting in a V13I substitution in Nsp5A, the main viral protease, in a patient who had not received antiviral therapy. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Handling Editor: Zhenhai Chen. |
ISSN: | 0304-8608 1432-8798 1432-8798 |
DOI: | 10.1007/s00705-021-05029-7 |