Search Results - "Østergaard, Jakob Appel"

MASP‐2 deficiency does not prevent the progression of diabetic kidney disease in a mouse model of type 1 diabetes by Charlotte Brinck, Holt, Lene, Halkjær, Tom, Dudler, Wilhelm, Schwaeble, Troels Krarup, Hansen, Steffen, Thiel, Jakob Appel, Østergaard

“…Mannan‐binding lectin (MBL) initiates the lectin pathway of complement and has been linked to albuminuria and mortality in diabetes. We hypothesize that…”
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Attenuation of Cortically Evoked Motor-Neuron Potential in Streptozotocin-Induced Diabetic Rats: A Study about the Effect of Diabetes upon Cortical-Initiated Movement by Pedersen, Michael, Andersen, Henning, Østergaard, Jakob Appel, Madsen, Jesper Guldsmed

“…Aims/Hypothesis. The complications affecting the peripheral nervous system, associated with diabetes mellitus, have been the focus of considerable research…”
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Antioxidant treatment attenuates lactate production in diabetic nephropathy by Laustsen, Christoffer, Nielsen, Per Mose, Nørlinger, Thomas Stokholm, Qi, Haiyun, Pedersen, Uffe Kjærgaard, Bertelsen, Lotte Bonde, Østergaard, Jakob Appel, Flyvbjerg, Allan, Ardenkjær-Larsen, Jan Henrik, Palm, Fredrik, Stødkilde-Jørgensen, Hans

“…The early progression of diabetic nephropathy is notoriously difficult to detect and quantify before the occurrence of substantial histological damage…”
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Diabetes Is Associated with Increased Autoreactivity of Mannan-Binding Lectin by Hansen, Troels Krarup, Thiel, Steffen, Østergaard, Jakob Appel, Axelgaard, Esben

“…Mannan-binding lectin (MBL) has been reported to be involved in the pathophysiology of diabetic nephropathy. MBL is a pattern-recognition molecule of the…”
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Complement Receptor 2 Based Immunoassay Measuring Activation of the Complement System at C3-Level in Plasma Samples From Mice and Humans by Halkjær, Lene, Troldborg, Anne, Pedersen, Henrik, Jensen, Lisbeth, Hansen, Annette Gudmann, Hansen, Troels Krarup, Bjerre, Mette, Østergaard, Jakob Appel, Thiel, Steffen

“…We aimed at establishing a sensitive and robust assay for estimation of systemic complement activation at complement component C3 level in mouse and human…”
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Global Autorecognition and Activation of Complement by Mannan-Binding Lectin in a Mouse Model of Type 1 Diabetes by Thiel, Steffen, Haxha, Saranda, Østergaard, Jakob Appel, Axelgaard, Esben, Hansen, Troels Krarup

“…Increasing evidence links mannan-binding lectin (MBL) to late vascular complications of diabetes. MBL is a complement-activating pattern recognition molecule…”
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Insufficient insulin administration to diabetic rats increases substrate utilization and maintains lactate production in the kidney by Laustsen, Christoffer, Lipsø, Kasper, Østergaard, Jakob Appel, Nørregaard, Rikke, Flyvbjerg, Allan, Pedersen, Michael, Palm, Fredrik, Ardenkjær‐Larsen, Jan Henrik

“…Good glycemic control is crucial to prevent the onset and progression of late diabetic complications, but insulin treatment often fails to achieve…”
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Ficolin B in Diabetic Kidney Disease in a Mouse Model of Type 1 Diabetes by Hansen, Troels Krarup, Endo, Yuichi, Nielsen, Gitte Krogh, Axelgaard, Esben, Østergaard, Jakob Appel, Holt, Charlotte Berg, Thiel, Steffen

“…Background. The innate immune system may have adverse effects in diabetes and cardiovascular disease. The complement system seems to play a key role through…”
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Increased Autoreactivity of the Complement-Activating Molecule Mannan-Binding Lectin in a Type 1 Diabetes Model by Hansen, Troels Krarup, Pickering, Matthew Caleb, Hoffmann-Petersen, Ingeborg Torp, Malik, Talat Habib, Ruseva, Marieta Milkova, Østergaard, Jakob Appel, Thiel, Steffen

“…Background. Diabetic kidney disease is the leading cause of end-stage renal failure despite intensive treatment of modifiable risk factors. Identification of…”
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Targeting oxidative stress and anti-oxidant defence in diabetic kidney disease by Østergaard, Jakob Appel, Cooper, Mark Emmanuel, Jandeleit-Dahm, Karin Agnes Maria

“…There is an unmet need for new strategies to prevent or postpone the development of diabetic kidney disease. The pathophysiology of this condition includes as…”
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Effect of Optimization of Glycaemic Control on Mannan-Binding Lectin in Type 1 Diabetes by Østergaard, Jakob Appel, Thiel, Steffen, Holt, Charlotte Berg, Dørflinger, Gry Høst, Hansen, Troels Krarup

“…Objective. Mannan-binding lectin (MBL) concentration in plasma is increased in subjects with type 1 diabetes and associated with increased mortality and risk…”
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Investigation of metabolic changes in STZ‐induced diabetic rats with hyperpolarized [1‐13C]acetate by Koellisch, Ulrich, Laustsen, Christoffer, Nørlinger, Thomas S., Østergaard, Jakob Appel, Flyvbjerg, Allan, Gringeri, Concetta V., Menzel, Marion I., Schulte, Rolf F., Haase, Axel, Stødkilde‐Jørgensen, Hans

“…In the metabolism of acetate several enzymes are involved, which play an important role in free fatty acid oxidation. Fatty acid metabolism is altered in…”
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Sortilin Inhibition Protects Neurons From Degeneration in the Diabetic Retina by Jakobsen, Thomas Stax, Østergaard, Jakob Appel, Kjolby, Mads, Birch, Elisa Lund, Bek, Toke, Nykjaer, Anders, Corydon, Thomas J, Askou, Anne Louise

“…To investigate the level and localization of the multifunctional receptor sortilin in the diabetic retina, as well as the effect of sortilin inhibition on…”
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Effects of TNF-α blocking on experimental periodontitis and type 2 diabetes in obese diabetic Zucker rats by Grauballe, Morten Bay, Østergaard, Jakob Appel, Schou, Søren, Flyvbjerg, Allan, Holmstrup, Palle

“…Objective Tumour necrosis factor α (TNF‐α) is considered a key signalling modulator in the pathogenesis of both periodontitis (PD) and type 2 diabetes mellitus…”
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Identification of Individuals With Undiagnosed Diabetes and Pre‐Diabetes in a Danish Cohort Attending Dental Treatment by Holm, Niels‐Christian Reimers, Belstrøm, Daniel, Østergaard, Jakob Appel, Schou, Søren, Holmstrup, Palle, Grauballe, Morten Bay

“…Background: It is estimated that 3.6% and 13.6% of the Danish population have undiagnosed type 2 diabetes mellitus and prediabetes, respectively. Periodontitis…”
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Should There be Concern About Autoimmune Diabetes in Adults? Current Evidence and Controversies by Østergaard, Jakob Appel, Laugesen, Esben, Leslie, R. David

“…Autoimmune diabetes has a heterogeneous phenotype. Although often considered a condition starting in childhood, a substantial proportion of type 1 diabetes…”
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Assessment of early diabetic renal changes with hyperpolarized [1-13C]pyruvate by Laustsen, Christoffer, Østergaard, Jakob Appel, Lauritzen, Mette Hauge, Nørregaard, Rikke, Bowen, Sean, Søgaard, Lise Vejby, Flyvbjerg, Allan, Pedersen, Michael, Ardenkjær-Larsen, Jan Henrik

“…Background This experimental study explores a novel magnetic resonance imaging/spectroscopic (MRI/MRS) method that measures changes in renal metabolism in a…”
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The pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes by Østergaard, Jakob Appel, Jansson Sigfrids, Fanny, Forsblom, Carol, Dahlström, Emma H., Thorn, Lena M., Harjutsalo, Valma, Flyvbjerg, Allan, Thiel, Steffen, Hansen, Troels Krarup, Groop, Per-Henrik

“…H-ficolin recognizes patterns on microorganisms and stressed cells and can activate the lectin pathway of the complement system. We aimed to assess H-ficolin…”
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Comment on: Lin et al. (2010) Immune cell-derived C3 is required for autoimmune diabetes induced by multiple low doses of streptozotocin. Diabetes;59: 2247-2252 by Ostergaard, Jakob Appel, Thiel, Steffen, Hansen, Troels Krarup, Rasch, Ruth, Flyvbjerg, Allan

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High Intrarenal Lactate Production Inhibits the Renal Pseudohypoxic Response to Acutely Induced Hypoxia in Diabetes by Laustsen, Christoffer, Lipsø, Kasper, Østergaard, Jakob Appel, Nielsen, Per Mose, Bertelsen, Lotte Bonde, Flyvbjerg, Allan, Pedersen, Michael, Palm, Fredrik, Ardenkjær-Larsen, Jan Henrik

“…Intrarenal hypoxia develops within a few days after the onset of insulinopenic diabetes in an experimental animal model (ie, a model of type-1 diabetes)…”
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